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• W2111736994 endingPage "9181" @default.
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• W2111736994 abstract "ABSTRACT To investigate the effect of nucleosomes on nucleotide excision repair in humans, we prepared a mononucleosome containing a (6-4) photoproduct in the nucleosome core and examined its repair with the reconstituted human excision nuclease system and with cell extracts. Nucleosomal DNA is repaired at a rate of about 10% of that for naked DNA in both systems. These results are in agreement with in vivo data showing a considerably slower rate of repair of overall genomic DNA relative to that for transcriptionally active DNA. Furthermore, our results indicate that the first-order packing of DNA in nucleosomes is a primary determinant of slow repair of DNA in chromatin." @default.
• W2111736994 created "2016-06-24" @default.
• W2111736994 creator A5016678671 @default.
• W2111736994 creator A5047556528 @default.
• W2111736994 creator A5049005722 @default.
• W2111736994 date "2000-12-01" @default.
• W2111736994 modified "2023-10-16" @default.
• W2111736994 title "DNA Damage in the Nucleosome Core Is Refractory to Repair by Human Excision Nuclease" @default.
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• W2111736994 doi "https://doi.org/10.1128/mcb.20.24.9173-9181.2000" @default.
• W2111736994 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/102175" @default.
• W2111736994 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11094069" @default.
• W2111736994 hasPublicationYear "2000" @default.
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