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- W2111738984 abstract "The classic centrally acting antihypertensives such as clonidine, guanfacine and α-methyl-DOPA (via its active metabolite α-methyl-noradrenaline) induce peripheral sympathoinhibition and a fall in blood pressure as a result of α2-adrenoceptor stimulation in the brain stem. These drugs have lost much of their clinical importance because of their unfavourable side-effects (sedation, dry mouth, impotence), which are also mediated by α2-adrenoceptors, although in other anatomical regions. Moxonidine and rilmenidine are the examples of a new class of centrally acting antihypertensives, which cause peripheral sympathoinhibition mediated by imidazoline (I1)-receptors in the rostral ventromedulla (RVLM). Their side-effect profile appears to be better than that of clonidine and α-methyl-DOPA, probably because of a weaker affinity for α2-adrenoceptors.The mode of action, haemodynamic profile, antihypertensive efficacy and adverse reactions of the classic and newer centrally acting antihypertensives are the subject of the present survey.Attention is also paid to other therapeutic applications of centrally acting antihypertensives, such as congestive heart failure and the metabolic syndrome." @default.
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- W2111738984 date "1999-01-01" @default.
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- W2111738984 title "Centrally Acting Antihypertensive Drugs. Present and Future" @default.
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- W2111738984 doi "https://doi.org/10.3109/10641969909061015" @default.
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