FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111746105> ?p ?o ?g. }

• W2111746105 abstract "Infectious etiology in lymphoproliferative diseases has always been suspected. The pathogenic roles of human herpesvirus-6 (HHV-6) in acute leukemia have been of great interest. Discordant results to establish a link between HHV-6 activation and the genesis of acute leukemia have been observed. The objective of this study was to evaluate a possible association between HHV-6 infection and acute leukemia in children and adults, with a longitudinal follow-up at diagnosis, aplasia, remission and relapse. HHV-6 load was quantified by a quantitative real-time PCR in the blood and bone marrow samples from 37 children and 36 adults with acute leukemia: 33 B acute lymphoblastic leukemia (B-ALL), 6 T acute lymphoblastic leukemia (T-ALL), 34 acute myeloid leukemia (AML). HHV-6 was detected in 15%, 8%, 30% and 28% of the blood samples at diagnosis, aplasia, remission and relapse, respectively. The median viral loads were 138, 244, 112 and 78 copies/million cells at diagnosis, aplasia, remission and relapse, respectively. In the bone marrow samples, HHV-6 was detected in 5%, 20% and 23% of the samples at diagnosis, remission and relapse, respectively. The median viral loads were 34, 109 and 32 copies/million cells at diagnosis, remission and relapse, respectively. According to the type of leukemia at diagnosis, HHV-6 was detected in 19% of the blood samples and in 7% of the bone marrow samples (with median viral loads at 206 and 79 copies/million cells, respectively) from patients with B-ALL. For patients with AML, HHV-6 was present in 8% of the blood samples and in 4% of the bone marrow samples (with median viral loads at 68 and 12 copies/million cells, respectively). HHV-6 was more prevalent in the blood samples from children than from adults (25% and 9%, respectively) and for the bone marrow (11% and 0%, respectively). All typable HHV-6 were HHV-6B species. No link was shown between neither the clinical symptoms nor the abnormal karyotype and HHV-6 activation. A case of HHV-6 chromosomal integration was shown in one patient with AML. This study confirms the absence of role of HHV-6 in the genesis of acute leukemia but the virus was reactivated after chemotherapy treatment." @default.
• W2111746105 created "2016-06-24" @default.
• W2111746105 creator A5013614257 @default.
• W2111746105 creator A5018053892 @default.
• W2111746105 creator A5028442182 @default.
• W2111746105 creator A5035304141 @default.
• W2111746105 creator A5038834097 @default.
• W2111746105 creator A5046279721 @default.
• W2111746105 creator A5050578528 @default.
• W2111746105 creator A5054591807 @default.
• W2111746105 creator A5084209829 @default.
• W2111746105 date "2012-11-12" @default.
• W2111746105 modified "2023-09-25" @default.
• W2111746105 title "Quantitative analysis of human herpesvirus-6 genome in blood and bone marrow samples from Tunisian patients with acute leukemia: a follow-up study" @default.
• W2111746105 cites W1854328606 @default.
• W2111746105 cites W1963829537 @default.
• W2111746105 cites W1971740336 @default.
• W2111746105 cites W1978504145 @default.
• W2111746105 cites W2007608712 @default.
• W2111746105 cites W2008645723 @default.
• W2111746105 cites W2008650129 @default.
• W2111746105 cites W2014512891 @default.
• W2111746105 cites W2036667886 @default.
• W2111746105 cites W2040304577 @default.
• W2111746105 cites W2043892841 @default.
• W2111746105 cites W2044146990 @default.
• W2111746105 cites W2054647994 @default.
• W2111746105 cites W2064131967 @default.
• W2111746105 cites W2077055182 @default.
• W2111746105 cites W2078914879 @default.
• W2111746105 cites W2111471104 @default.
• W2111746105 cites W2115669202 @default.
• W2111746105 cites W2121338893 @default.
• W2111746105 cites W2156222970 @default.
• W2111746105 cites W2163698603 @default.
• W2111746105 cites W2171021556 @default.
• W2111746105 doi "https://doi.org/10.1186/1750-9378-7-31" @default.
• W2111746105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3527176" @default.
• W2111746105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23146098" @default.
• W2111746105 hasPublicationYear "2012" @default.
• W2111746105 type Work @default.
• W2111746105 sameAs 2111746105 @default.
• W2111746105 citedByCount "10" @default.
• W2111746105 countsByYear W21117461052013 @default.
• W2111746105 countsByYear W21117461052014 @default.
• W2111746105 countsByYear W21117461052016 @default.
• W2111746105 countsByYear W21117461052018 @default.
• W2111746105 countsByYear W21117461052019 @default.
• W2111746105 countsByYear W21117461052020 @default.
• W2111746105 crossrefType "journal-article" @default.
• W2111746105 hasAuthorship W2111746105A5013614257 @default.
• W2111746105 hasAuthorship W2111746105A5018053892 @default.
• W2111746105 hasAuthorship W2111746105A5028442182 @default.
• W2111746105 hasAuthorship W2111746105A5035304141 @default.
• W2111746105 hasAuthorship W2111746105A5038834097 @default.
• W2111746105 hasAuthorship W2111746105A5046279721 @default.
• W2111746105 hasAuthorship W2111746105A5050578528 @default.
• W2111746105 hasAuthorship W2111746105A5054591807 @default.
• W2111746105 hasAuthorship W2111746105A5084209829 @default.
• W2111746105 hasBestOaLocation W21117461051 @default.
• W2111746105 hasConcept C126322002 @default.
• W2111746105 hasConcept C142462285 @default.
• W2111746105 hasConcept C203014093 @default.
• W2111746105 hasConcept C2522874641 @default.
• W2111746105 hasConcept C2776863199 @default.
• W2111746105 hasConcept C2778368355 @default.
• W2111746105 hasConcept C2778461978 @default.
• W2111746105 hasConcept C2778729363 @default.
• W2111746105 hasConcept C2780007613 @default.
• W2111746105 hasConcept C2781107101 @default.
• W2111746105 hasConcept C2909962599 @default.
• W2111746105 hasConcept C71924100 @default.
• W2111746105 hasConcept C90924648 @default.
• W2111746105 hasConceptScore W2111746105C126322002 @default.
• W2111746105 hasConceptScore W2111746105C142462285 @default.
• W2111746105 hasConceptScore W2111746105C203014093 @default.
• W2111746105 hasConceptScore W2111746105C2522874641 @default.
• W2111746105 hasConceptScore W2111746105C2776863199 @default.
• W2111746105 hasConceptScore W2111746105C2778368355 @default.
• W2111746105 hasConceptScore W2111746105C2778461978 @default.
• W2111746105 hasConceptScore W2111746105C2778729363 @default.
• W2111746105 hasConceptScore W2111746105C2780007613 @default.
• W2111746105 hasConceptScore W2111746105C2781107101 @default.
• W2111746105 hasConceptScore W2111746105C2909962599 @default.
• W2111746105 hasConceptScore W2111746105C71924100 @default.
• W2111746105 hasConceptScore W2111746105C90924648 @default.
• W2111746105 hasIssue "1" @default.
• W2111746105 hasLocation W21117461051 @default.
• W2111746105 hasLocation W21117461052 @default.
• W2111746105 hasLocation W21117461053 @default.
• W2111746105 hasLocation W21117461054 @default.
• W2111746105 hasOpenAccess W2111746105 @default.
• W2111746105 hasPrimaryLocation W21117461051 @default.
• W2111746105 hasRelatedWork W1975515932 @default.
• W2111746105 hasRelatedWork W2048128978 @default.
• W2111746105 hasRelatedWork W2065008538 @default.
• W2111746105 hasRelatedWork W2111746105 @default.
• W2111746105 hasRelatedWork W2345640867 @default.
• W2111746105 hasRelatedWork W2364623633 @default.
• W2111746105 hasRelatedWork W2380323156 @default.

• next