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- W2111750633 abstract "The application of medications to the skin to ease ailments is a practice that has been utilized by humankind over the millennia and has included the application of poultices, gels, ointments, creams, and pastes. These applications were primarily intended for a local topical effect. The use of adhesive skin patches to deliver drugs systemically is a relatively new phenomenon. The first adhesive transdermal delivery system (TDDS) patch was approved by the Food and Drug Administration in 1979 (scopolamine patch for motion sickness). Nitroglycerine patches were approved in 1981. This method of delivery became widely recognized when nicotine patches for smoking cessation were introduced in 1991. TDDS offer pharmacological advantages over the oral route and improved patient acceptability and compliance. As such, they have been an important area of pharmaceutical research and development over the last few decades. Conditions for which TDDS are suitable are detailed in Table 1." @default.
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- W2111750633 date "2007-10-01" @default.
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- W2111750633 title "Transdermal drug delivery: principles and opioid therapy" @default.
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- W2111750633 doi "https://doi.org/10.1093/bjaceaccp/mkm033" @default.
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