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- W2111759307 abstract "A cDNA sequence with homologies to members of the LPS-binding protein and bactericidal/permeability-increasing protein (BPI) family was identified in the oyster Crassostrea gigas . The recombinant protein was found to bind LPS, to display bactericidal activity against Escherichia coli , and to increase the permeability of the bacterial cytoplasmic membrane. This indicated that it is a BPI rather than an LPS-binding protein. By in situ hybridization, the expression of the C. gigas BPI ( Cg-bpi ) was found to be induced in hemocytes after oyster bacterial challenge and to be constitutive in various epithelia of unchallenged oysters. Thus, Cg-bpi transcripts were detected in the epithelial cells of tissues/organs in contact with the external environment (mantle, gills, digestive tract, digestive gland diverticula, and gonad follicles). Therefore, Cg -BPI, whose expression profile and biological properties are reminiscent of mammalian BPIs, may provide a first line of defense against potential bacterial invasion. To our knowledge, this is the first characterization of a BPI in an invertebrate." @default.
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- W2111759307 date "2007-11-06" @default.
- W2111759307 modified "2023-10-08" @default.
- W2111759307 title "Evidence of a bactericidal permeability increasing protein in an invertebrate, the <i>Crassostrea gigas Cg</i> -BPI" @default.
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- W2111759307 doi "https://doi.org/10.1073/pnas.0702281104" @default.
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