FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111763105> ?p ?o ?g. }

• W2111763105 endingPage "1219" @default.
• W2111763105 startingPage "1213" @default.
• W2111763105 abstract "In clinical research, the definition of the upper limit of normal (ULN) alanine transaminase (ALT) is never detailed. However, such a definition can vary and may have practical consequences. Our aim was to assess factors associated with serum ALT activity in apparently healthy subjects and then to apply seven different definitions of ULN in three different populations so as to assess the prevalence of subjects with normal ALT among blood donors and among hepatitis C patients before (normal ALT hepatitis C patients) and after treatment (interferon [IFN] responders). ALT measurements were performed in the same laboratory using the same technique; 1,033 donors were prospectively investigated, 186 patients with hepatitis C never treated and 40 patients treated with 3 MU three times per week of IFN-alpha for at least 6 months. The seven definitions (D) of ULN were: D1: 95th percentile of ALT; D2: 95th percentile after separating males and females; D3: males and females separately, ULN=10 (mean of log10 ALT + 1.96 SD); D4: ULN=45 IU/L given by the manufacturer; D5: mean + 1 SD after exclusion of the 5% extreme values; D6: 95th percentile after separating subjects with body mass index (BMI) under or equal to the median (23); and D7: 95th percentile after separating subjects according to BMI and sex. BMI and male sex were independently associated (P < .0001; logistic regression) with ALT, without an association with alcohol. The range of ULN varied from 26 IU/L in females (D5) to 66 IU/L in males with BMI >23 (D7). Depending on the definition, the prevalence of blood donors with normal ALT varied from 82% to 96%, i.e., a range of 14%; that of hepatitis C patients with normal ALT varied from 16% to 27%, i.e., a range of 11%; the prevalence of IFN responders varied from 25% to 42%, i.e., a range of 17%. Definitions of normal ALT values should be adjusted for sex and BMI to reduce artificial heterogeneity in blood donor selection and in hepatitis C clinical studies." @default.
• W2111763105 created "2016-06-24" @default.
• W2111763105 creator A5016736959 @default.
• W2111763105 creator A5030245404 @default.
• W2111763105 creator A5050243883 @default.
• W2111763105 creator A5052660173 @default.
• W2111763105 creator A5059468957 @default.
• W2111763105 creator A5071910351 @default.
• W2111763105 creator A5086453278 @default.
• W2111763105 creator A5089530566 @default.
• W2111763105 date "1998-05-01" @default.
• W2111763105 modified "2023-10-14" @default.
• W2111763105 title "Factors associated with serum alanine transaminase activity in healthy subjects: Consequences for the definition of normal values, for selection of blood donors, and for patients with chronic hepatitis C" @default.
• W2111763105 cites W1542051885 @default.
• W2111763105 cites W1973321006 @default.
• W2111763105 cites W2025596364 @default.
• W2111763105 cites W2069633422 @default.
• W2111763105 cites W2080168089 @default.
• W2111763105 cites W2080285703 @default.
• W2111763105 cites W2096151024 @default.
• W2111763105 cites W2097196081 @default.
• W2111763105 cites W2102785869 @default.
• W2111763105 cites W2116028889 @default.
• W2111763105 cites W2132290252 @default.
• W2111763105 cites W2143089664 @default.
• W2111763105 doi "https://doi.org/10.1002/hep.510270505" @default.
• W2111763105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9581673" @default.
• W2111763105 hasPublicationYear "1998" @default.
• W2111763105 type Work @default.
• W2111763105 sameAs 2111763105 @default.
• W2111763105 citedByCount "282" @default.
• W2111763105 countsByYear W21117631052012 @default.
• W2111763105 countsByYear W21117631052013 @default.
• W2111763105 countsByYear W21117631052014 @default.
• W2111763105 countsByYear W21117631052015 @default.
• W2111763105 countsByYear W21117631052016 @default.
• W2111763105 countsByYear W21117631052017 @default.
• W2111763105 countsByYear W21117631052018 @default.
• W2111763105 countsByYear W21117631052019 @default.
• W2111763105 countsByYear W21117631052020 @default.
• W2111763105 countsByYear W21117631052021 @default.
• W2111763105 countsByYear W21117631052022 @default.
• W2111763105 countsByYear W21117631052023 @default.
• W2111763105 crossrefType "journal-article" @default.
• W2111763105 hasAuthorship W2111763105A5016736959 @default.
• W2111763105 hasAuthorship W2111763105A5030245404 @default.
• W2111763105 hasAuthorship W2111763105A5050243883 @default.
• W2111763105 hasAuthorship W2111763105A5052660173 @default.
• W2111763105 hasAuthorship W2111763105A5059468957 @default.
• W2111763105 hasAuthorship W2111763105A5071910351 @default.
• W2111763105 hasAuthorship W2111763105A5086453278 @default.
• W2111763105 hasAuthorship W2111763105A5089530566 @default.
• W2111763105 hasBestOaLocation W21117631051 @default.
• W2111763105 hasConcept C105795698 @default.
• W2111763105 hasConcept C122048520 @default.
• W2111763105 hasConcept C126322002 @default.
• W2111763105 hasConcept C141071460 @default.
• W2111763105 hasConcept C151956035 @default.
• W2111763105 hasConcept C160160445 @default.
• W2111763105 hasConcept C181199279 @default.
• W2111763105 hasConcept C2776877979 @default.
• W2111763105 hasConcept C2778606649 @default.
• W2111763105 hasConcept C2779679107 @default.
• W2111763105 hasConcept C2780221984 @default.
• W2111763105 hasConcept C2992872382 @default.
• W2111763105 hasConcept C33923547 @default.
• W2111763105 hasConcept C41260117 @default.
• W2111763105 hasConcept C55493867 @default.
• W2111763105 hasConcept C71924100 @default.
• W2111763105 hasConcept C86803240 @default.
• W2111763105 hasConcept C90924648 @default.
• W2111763105 hasConceptScore W2111763105C105795698 @default.
• W2111763105 hasConceptScore W2111763105C122048520 @default.
• W2111763105 hasConceptScore W2111763105C126322002 @default.
• W2111763105 hasConceptScore W2111763105C141071460 @default.
• W2111763105 hasConceptScore W2111763105C151956035 @default.
• W2111763105 hasConceptScore W2111763105C160160445 @default.
• W2111763105 hasConceptScore W2111763105C181199279 @default.
• W2111763105 hasConceptScore W2111763105C2776877979 @default.
• W2111763105 hasConceptScore W2111763105C2778606649 @default.
• W2111763105 hasConceptScore W2111763105C2779679107 @default.
• W2111763105 hasConceptScore W2111763105C2780221984 @default.
• W2111763105 hasConceptScore W2111763105C2992872382 @default.
• W2111763105 hasConceptScore W2111763105C33923547 @default.
• W2111763105 hasConceptScore W2111763105C41260117 @default.
• W2111763105 hasConceptScore W2111763105C55493867 @default.
• W2111763105 hasConceptScore W2111763105C71924100 @default.
• W2111763105 hasConceptScore W2111763105C86803240 @default.
• W2111763105 hasConceptScore W2111763105C90924648 @default.
• W2111763105 hasIssue "5" @default.
• W2111763105 hasLocation W21117631051 @default.
• W2111763105 hasLocation W21117631052 @default.
• W2111763105 hasOpenAccess W2111763105 @default.
• W2111763105 hasPrimaryLocation W21117631051 @default.
• W2111763105 hasRelatedWork W1900691840 @default.
• W2111763105 hasRelatedWork W228938742 @default.
• W2111763105 hasRelatedWork W2349624551 @default.
• W2111763105 hasRelatedWork W2745950292 @default.

• next