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- W2111773310 abstract "The delay in skeletal muscle mitochondrial ATP production at the onset of exercise is thought to be a function of a limited oxygen supply. The delay, termed the oxygen deficit, can be quantified by assessing the above baseline oxygen consumption during the first few minutes of recovery from exercise. During submaximal exercise, the oxygen deficit is reflected by the extent of muscle phosphocreatine (PCr) breakdown. In the present study, nine male subjects performed 8 min of submaximal, single leg knee extension exercise after saline (Control) and dichloroacetate (DCA) infusion on two separate occasions. Administration of DCA increased resting skeletal muscle pyruvate dehydrogenase complex activation status threefold (Control = 0.4 ± 0.1 vs. DCA = 1.3 ± 0.1 mmol acetyl-CoA ⋅ min −1 ⋅ kg wet muscle −1 at 37°C, P < 0.01) and elevated acetylcarnitine concentration fivefold (Control = 2.2 ± 0.5 vs. DCA = 10.9 ± 1.2 mmol/kg dry mass, P < 0.01). During exercise, PCr degradation was reduced by ∼50% after DCA (Control = 33.2 ± 7.1 vs. DCA = 18.4 ± 7.1 mmol/kg dry mass, P < 0.05). It would appear, therefore, that in humans acetyl group availability is a major determinant of the rate of increase in mitochondrial respiration at the onset of exercise and hence the oxygen deficit." @default.
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- W2111773310 title "Muscle acetyl group availability is a major determinant of oxygen deficit in humans during submaximal exercise" @default.
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- W2111773310 doi "https://doi.org/10.1152/ajpendo.1998.274.2.e377" @default.
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