FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111775984> ?p ?o ?g. }

• W2111775984 endingPage "16" @default.
• W2111775984 startingPage "11" @default.
• W2111775984 abstract "The most common human cell-based therapy applied today is hematopoietic stem cell (HSC) transplantation. HSCs can be defined by two essential properties: self-renewal and multilineage hematopoietic differentiation. These combined HSC properties allow them to differentiate into all blood cell types (multilineage) in a sustained manner for the lifetime of the animal, which requires their ability to make cellular copies of themselves (self-renewal). These features can be tested by transplantation from donor to recipient and provide a functional basis to define and identify HSCs. Currently, human bone marrow (BM), mobilized peripheral blood, and umbilical cord blood (CB) represent the major sources of transplantable HSCs, but their availability for use is limited by both quantity and compatibility. Although increasing evidence suggests that somatic HSCs can be expanded to meet current needs, their in vivo potential is concomitantly compromised after ex vivo culture. Pluripotent human embryonic stem cells (hESCs) may provide an alternative. hESCs possess indefinite proliferative capacity in vitro, and have been shown to differentiate into the hematopoietic cell fate, giving rise to erythroid, myeloid, and lymphoid lineages using a variety of differentiation procedures. In most cases, hESC-derived hematopoietic cells show similar clonogenic progenitor capacity and primitive phenotype to somatic sources of hematopoietic progenitors, but possess limited in vivo repopulating capacity when transplanted into immunodeficient mice. Although this suggests HSC function can be derived from hESCs, the efficiency and quality of these cells must be characterized using surrogate models for potential clinical applications." @default.
• W2111775984 created "2016-06-24" @default.
• W2111775984 creator A5064624681 @default.
• W2111775984 date "2007-01-01" @default.
• W2111775984 modified "2023-09-27" @default.
• W2111775984 title "Hematopoietic Development from Human Embryonic Stem Cells" @default.
• W2111775984 cites W1490988862 @default.
• W2111775984 cites W1603508604 @default.
• W2111775984 cites W1653639829 @default.
• W2111775984 cites W1803036763 @default.
• W2111775984 cites W1967166817 @default.
• W2111775984 cites W1969483592 @default.
• W2111775984 cites W1970023965 @default.
• W2111775984 cites W1983741863 @default.
• W2111775984 cites W1987803647 @default.
• W2111775984 cites W1988865085 @default.
• W2111775984 cites W1990293394 @default.
• W2111775984 cites W1992838550 @default.
• W2111775984 cites W1992949513 @default.
• W2111775984 cites W1994702653 @default.
• W2111775984 cites W2002768599 @default.
• W2111775984 cites W2003589118 @default.
• W2111775984 cites W2004340720 @default.
• W2111775984 cites W2008995006 @default.
• W2111775984 cites W2010353459 @default.
• W2111775984 cites W2014416902 @default.
• W2111775984 cites W2017446921 @default.
• W2111775984 cites W2021941798 @default.
• W2111775984 cites W2024306704 @default.
• W2111775984 cites W2027186896 @default.
• W2111775984 cites W2030406325 @default.
• W2111775984 cites W2039181101 @default.
• W2111775984 cites W2039824179 @default.
• W2111775984 cites W2047607934 @default.
• W2111775984 cites W2050637668 @default.
• W2111775984 cites W2051279916 @default.
• W2111775984 cites W2056483443 @default.
• W2111775984 cites W2057856249 @default.
• W2111775984 cites W2060974010 @default.
• W2111775984 cites W2061997335 @default.
• W2111775984 cites W2062118486 @default.
• W2111775984 cites W2066413879 @default.
• W2111775984 cites W2070588786 @default.
• W2111775984 cites W2081953725 @default.
• W2111775984 cites W2083763893 @default.
• W2111775984 cites W2086943348 @default.
• W2111775984 cites W2088088839 @default.
• W2111775984 cites W2089078614 @default.
• W2111775984 cites W2094557730 @default.
• W2111775984 cites W2095022753 @default.
• W2111775984 cites W2096946071 @default.
• W2111775984 cites W2097050852 @default.
• W2111775984 cites W2101556559 @default.
• W2111775984 cites W2104269891 @default.
• W2111775984 cites W2105493979 @default.
• W2111775984 cites W2110301828 @default.
• W2111775984 cites W2114673516 @default.
• W2111775984 cites W2124066511 @default.
• W2111775984 cites W2127432537 @default.
• W2111775984 cites W2128410548 @default.
• W2111775984 cites W2130975786 @default.
• W2111775984 cites W2133501984 @default.
• W2111775984 cites W2138088258 @default.
• W2111775984 cites W2138442302 @default.
• W2111775984 cites W2139961479 @default.
• W2111775984 cites W2155143410 @default.
• W2111775984 cites W2156949967 @default.
• W2111775984 cites W2157333131 @default.
• W2111775984 cites W2163102268 @default.
• W2111775984 cites W2164231419 @default.
• W2111775984 cites W2181131337 @default.
• W2111775984 cites W4232310547 @default.
• W2111775984 cites W4238927690 @default.
• W2111775984 doi "https://doi.org/10.1182/asheducation-2007.1.11" @default.
• W2111775984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18024603" @default.
• W2111775984 hasPublicationYear "2007" @default.
• W2111775984 type Work @default.
• W2111775984 sameAs 2111775984 @default.
• W2111775984 citedByCount "21" @default.
• W2111775984 countsByYear W21117759842012 @default.
• W2111775984 countsByYear W21117759842013 @default.
• W2111775984 countsByYear W21117759842015 @default.
• W2111775984 countsByYear W21117759842020 @default.
• W2111775984 countsByYear W21117759842021 @default.
• W2111775984 crossrefType "journal-article" @default.
• W2111775984 hasAuthorship W2111775984A5064624681 @default.
• W2111775984 hasBestOaLocation W21117759841 @default.
• W2111775984 hasConcept C104317684 @default.
• W2111775984 hasConcept C107459253 @default.
• W2111775984 hasConcept C109159458 @default.
• W2111775984 hasConcept C117262875 @default.
• W2111775984 hasConcept C126322002 @default.
• W2111775984 hasConcept C145103041 @default.
• W2111775984 hasConcept C1491633281 @default.
• W2111775984 hasConcept C201750760 @default.
• W2111775984 hasConcept C203014093 @default.
• W2111775984 hasConcept C20875687 @default.
• W2111775984 hasConcept C2778086970 @default.

• next