Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111776173> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2111776173 endingPage "158" @default.
- W2111776173 startingPage "155" @default.
- W2111776173 abstract "Several cytokines have been shown to be expressed in normal and adenomatous pituitary tissue. Recently, interleukin-8 (IL-8) mRNA was identified by reverse transcription (RT)-PCR in each of a series of 17 pituitary tumours examined. We have investigated further the presence of IL-8 mRNA, using in situ hybridisation in two normal human anterior pituitary specimens and 25 human pituitary adenomas. IL-8 mRNA was not identified in either of the two normal pituitary specimens. Only three of the 25 adenomas were positive for IL-8 mRNA. In these three tumours, which included two null cell adenomas and one gonadotrophinoma, the majority of tumour cells (>90%) were positive for IL-8 mRNA. The remaining 22 adenomas were completely negative. There was no difference in tumour size or type between the IL-8 positive and the IL-8 negative tumours, and immunocytochemistry for von Willebrandt factor showed that the two groups were also similar in their degree of vascularisation. In conclusion, IL-8 mRNA was found in 12% of pituitary adenomas studied and was histologically identified within the tumour cells. In situ hybridisation is a more appropriate technique for assessing cytokine mRNA production by human pituitary tumours because RT-PCR may be too sensitive, identifying very small, possibly pathologically insignificant, quantities of mRNA that could be produced by supporting cells such as fibroblasts, endothelial cells or macrophages." @default.
- W2111776173 created "2016-06-24" @default.
- W2111776173 creator A5014817227 @default.
- W2111776173 creator A5018244294 @default.
- W2111776173 creator A5035115068 @default.
- W2111776173 creator A5061263779 @default.
- W2111776173 creator A5072353311 @default.
- W2111776173 creator A5085379342 @default.
- W2111776173 date "1999-02-01" @default.
- W2111776173 modified "2023-10-17" @default.
- W2111776173 title "IL-8 mRNA expression by in situ hybridisation in human pituitary adenomas" @default.
- W2111776173 cites W1977780068 @default.
- W2111776173 cites W2008720144 @default.
- W2111776173 cites W2011268436 @default.
- W2111776173 cites W2018374428 @default.
- W2111776173 cites W2027261258 @default.
- W2111776173 cites W2029790299 @default.
- W2111776173 cites W2040153233 @default.
- W2111776173 cites W2059614508 @default.
- W2111776173 cites W2069566015 @default.
- W2111776173 cites W2115630448 @default.
- W2111776173 doi "https://doi.org/10.1530/eje.0.1400155" @default.
- W2111776173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10069660" @default.
- W2111776173 hasPublicationYear "1999" @default.
- W2111776173 type Work @default.
- W2111776173 sameAs 2111776173 @default.
- W2111776173 citedByCount "25" @default.
- W2111776173 countsByYear W21117761732014 @default.
- W2111776173 countsByYear W21117761732019 @default.
- W2111776173 countsByYear W21117761732020 @default.
- W2111776173 crossrefType "journal-article" @default.
- W2111776173 hasAuthorship W2111776173A5014817227 @default.
- W2111776173 hasAuthorship W2111776173A5018244294 @default.
- W2111776173 hasAuthorship W2111776173A5035115068 @default.
- W2111776173 hasAuthorship W2111776173A5061263779 @default.
- W2111776173 hasAuthorship W2111776173A5072353311 @default.
- W2111776173 hasAuthorship W2111776173A5085379342 @default.
- W2111776173 hasBestOaLocation W21117761731 @default.
- W2111776173 hasConcept C104317684 @default.
- W2111776173 hasConcept C105580179 @default.
- W2111776173 hasConcept C121853132 @default.
- W2111776173 hasConcept C126322002 @default.
- W2111776173 hasConcept C134018914 @default.
- W2111776173 hasConcept C142724271 @default.
- W2111776173 hasConcept C203014093 @default.
- W2111776173 hasConcept C2777428134 @default.
- W2111776173 hasConcept C2777658017 @default.
- W2111776173 hasConcept C2778690821 @default.
- W2111776173 hasConcept C35866371 @default.
- W2111776173 hasConcept C54355233 @default.
- W2111776173 hasConcept C55493867 @default.
- W2111776173 hasConcept C71315377 @default.
- W2111776173 hasConcept C71924100 @default.
- W2111776173 hasConcept C81439078 @default.
- W2111776173 hasConcept C81885089 @default.
- W2111776173 hasConcept C86803240 @default.
- W2111776173 hasConceptScore W2111776173C104317684 @default.
- W2111776173 hasConceptScore W2111776173C105580179 @default.
- W2111776173 hasConceptScore W2111776173C121853132 @default.
- W2111776173 hasConceptScore W2111776173C126322002 @default.
- W2111776173 hasConceptScore W2111776173C134018914 @default.
- W2111776173 hasConceptScore W2111776173C142724271 @default.
- W2111776173 hasConceptScore W2111776173C203014093 @default.
- W2111776173 hasConceptScore W2111776173C2777428134 @default.
- W2111776173 hasConceptScore W2111776173C2777658017 @default.
- W2111776173 hasConceptScore W2111776173C2778690821 @default.
- W2111776173 hasConceptScore W2111776173C35866371 @default.
- W2111776173 hasConceptScore W2111776173C54355233 @default.
- W2111776173 hasConceptScore W2111776173C55493867 @default.
- W2111776173 hasConceptScore W2111776173C71315377 @default.
- W2111776173 hasConceptScore W2111776173C71924100 @default.
- W2111776173 hasConceptScore W2111776173C81439078 @default.
- W2111776173 hasConceptScore W2111776173C81885089 @default.
- W2111776173 hasConceptScore W2111776173C86803240 @default.
- W2111776173 hasLocation W21117761731 @default.
- W2111776173 hasLocation W21117761732 @default.
- W2111776173 hasOpenAccess W2111776173 @default.
- W2111776173 hasPrimaryLocation W21117761731 @default.
- W2111776173 hasRelatedWork W1966970701 @default.
- W2111776173 hasRelatedWork W1985310720 @default.
- W2111776173 hasRelatedWork W2057465799 @default.
- W2111776173 hasRelatedWork W2064571927 @default.
- W2111776173 hasRelatedWork W2066173879 @default.
- W2111776173 hasRelatedWork W2105328860 @default.
- W2111776173 hasRelatedWork W2122246436 @default.
- W2111776173 hasRelatedWork W2161296685 @default.
- W2111776173 hasRelatedWork W2162861005 @default.
- W2111776173 hasRelatedWork W2167140907 @default.
- W2111776173 isParatext "false" @default.
- W2111776173 isRetracted "false" @default.
- W2111776173 magId "2111776173" @default.
- W2111776173 workType "article" @default.