Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111777307> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2111777307 startingPage "332" @default.
- W2111777307 abstract "Purpose. The aim of this study was to examine the mechanism of pravastatin- and rosuvastatin-induced cytotoxicity and the relationship between pravastatin- and rosuvastatin-induced cytotoxicity and medium pH using human prototypic embryonal rhabdomyosarcoma cell line (RD) and rat myoblast cell line (L6) as a model of in vitro skeletal muscle. Methods. Statin-induced reduction of cell viability and apoptosis was measured by 3-(4,5-dimethylthiazol-2-yl)2,5 -diphenyl tetrazolium bromide (MTT) assay and caspase assay. Intracellular accumulation of statins was determined using an HPLC system. Results. Rosuvastatin cytotoxicity, reduction of cell viability, morphological changes and caspase activation at acidic pH (pH 6.8) were significantly greater than those at neutral pH (pH 7.4). Rosuvastatin accumulation at acidic pH was greater than that at pH 7.4. On the other hand, medium pH had no effect on pravastatin accumulation. Conclusions. Rosuvastatin cytotoxicity at acidic pH is associated with increasing intracellular accumulation of rosuvastatin. On the other hand, medium pH had no effect on cytotoxicity of pravastatin." @default.
- W2111777307 created "2016-06-24" @default.
- W2111777307 creator A5001367357 @default.
- W2111777307 creator A5002804707 @default.
- W2111777307 creator A5016721695 @default.
- W2111777307 creator A5018357505 @default.
- W2111777307 creator A5045347848 @default.
- W2111777307 creator A5072802967 @default.
- W2111777307 date "2007-01-01" @default.
- W2111777307 modified "2023-09-27" @default.
- W2111777307 title "Effect of medium pH on the cytotoxicity of hydrophilic statins." @default.
- W2111777307 cites W1522763255 @default.
- W2111777307 cites W1775749144 @default.
- W2111777307 cites W1778499707 @default.
- W2111777307 cites W2005685522 @default.
- W2111777307 cites W2015775189 @default.
- W2111777307 cites W2067236087 @default.
- W2111777307 cites W2085761675 @default.
- W2111777307 cites W2114918609 @default.
- W2111777307 cites W2129750583 @default.
- W2111777307 cites W2131275408 @default.
- W2111777307 cites W2144755243 @default.
- W2111777307 cites W2306744213 @default.
- W2111777307 cites W2312580977 @default.
- W2111777307 cites W2582937380 @default.
- W2111777307 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17727796" @default.
- W2111777307 hasPublicationYear "2007" @default.
- W2111777307 type Work @default.
- W2111777307 sameAs 2111777307 @default.
- W2111777307 citedByCount "8" @default.
- W2111777307 countsByYear W21117773072015 @default.
- W2111777307 countsByYear W21117773072016 @default.
- W2111777307 countsByYear W21117773072021 @default.
- W2111777307 countsByYear W21117773072022 @default.
- W2111777307 crossrefType "journal-article" @default.
- W2111777307 hasAuthorship W2111777307A5001367357 @default.
- W2111777307 hasAuthorship W2111777307A5002804707 @default.
- W2111777307 hasAuthorship W2111777307A5016721695 @default.
- W2111777307 hasAuthorship W2111777307A5018357505 @default.
- W2111777307 hasAuthorship W2111777307A5045347848 @default.
- W2111777307 hasAuthorship W2111777307A5072802967 @default.
- W2111777307 hasConcept C109316439 @default.
- W2111777307 hasConcept C185592680 @default.
- W2111777307 hasConcept C190283241 @default.
- W2111777307 hasConcept C202751555 @default.
- W2111777307 hasConcept C2778163477 @default.
- W2111777307 hasConcept C2779519902 @default.
- W2111777307 hasConcept C2780499067 @default.
- W2111777307 hasConcept C2780783641 @default.
- W2111777307 hasConcept C53227056 @default.
- W2111777307 hasConcept C55493867 @default.
- W2111777307 hasConcept C79879829 @default.
- W2111777307 hasConcept C86803240 @default.
- W2111777307 hasConcept C98274493 @default.
- W2111777307 hasConceptScore W2111777307C109316439 @default.
- W2111777307 hasConceptScore W2111777307C185592680 @default.
- W2111777307 hasConceptScore W2111777307C190283241 @default.
- W2111777307 hasConceptScore W2111777307C202751555 @default.
- W2111777307 hasConceptScore W2111777307C2778163477 @default.
- W2111777307 hasConceptScore W2111777307C2779519902 @default.
- W2111777307 hasConceptScore W2111777307C2780499067 @default.
- W2111777307 hasConceptScore W2111777307C2780783641 @default.
- W2111777307 hasConceptScore W2111777307C53227056 @default.
- W2111777307 hasConceptScore W2111777307C55493867 @default.
- W2111777307 hasConceptScore W2111777307C79879829 @default.
- W2111777307 hasConceptScore W2111777307C86803240 @default.
- W2111777307 hasConceptScore W2111777307C98274493 @default.
- W2111777307 hasIssue "3" @default.
- W2111777307 hasLocation W21117773071 @default.
- W2111777307 hasLocation W21117773072 @default.
- W2111777307 hasOpenAccess W2111777307 @default.
- W2111777307 hasPrimaryLocation W21117773071 @default.
- W2111777307 hasRelatedWork W1819048918 @default.
- W2111777307 hasRelatedWork W1993202243 @default.
- W2111777307 hasRelatedWork W1999069447 @default.
- W2111777307 hasRelatedWork W2000175026 @default.
- W2111777307 hasRelatedWork W2048591484 @default.
- W2111777307 hasRelatedWork W2060646951 @default.
- W2111777307 hasRelatedWork W2079263790 @default.
- W2111777307 hasRelatedWork W2114929840 @default.
- W2111777307 hasRelatedWork W2129046210 @default.
- W2111777307 hasRelatedWork W2166410456 @default.
- W2111777307 hasRelatedWork W2186559060 @default.
- W2111777307 hasRelatedWork W2274741057 @default.
- W2111777307 hasRelatedWork W2350965768 @default.
- W2111777307 hasRelatedWork W2385428541 @default.
- W2111777307 hasRelatedWork W2389232795 @default.
- W2111777307 hasRelatedWork W3021842468 @default.
- W2111777307 hasRelatedWork W323391365 @default.
- W2111777307 hasRelatedWork W783309682 @default.
- W2111777307 hasRelatedWork W19279330 @default.
- W2111777307 hasRelatedWork W2187537539 @default.
- W2111777307 hasVolume "10" @default.
- W2111777307 isParatext "false" @default.
- W2111777307 isRetracted "false" @default.
- W2111777307 magId "2111777307" @default.
- W2111777307 workType "article" @default.