Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111781151> ?p ?o ?g. }
- W2111781151 endingPage "4828" @default.
- W2111781151 startingPage "4820" @default.
- W2111781151 abstract "Abstract The Myc pathway, often deregulated in cancer, is critical in determining cell fate by coordinating a gene expression program that links the control of cell proliferation with cell fate decisions. As such, precise control of the Myc pathway activity must be achieved to ensure faithful execution of appropriate cellular response and to prevent progressing toward a malignant state. With recent highlighted roles of microRNAs (miRNA) as critical components of gene control, we sought to evaluate the extent to which miRNAs may contribute in the execution of Myc function. Combined analysis of mRNA and miRNA expression profiles reveals an integration whereby the Myc-mediated induction of miRNAs leads to the repression of various mRNAs encoding tumor suppressors that block cell proliferation including p21, p27, and Rb. In addition, the proapoptotic PTEN tumor suppressor gene is also repressed by Myc-induced miRNAs, suggesting that Myc-induced miRNAs contribute to the precise control of a transcriptional program that coordinates the balance of cell proliferation and cell death. Cancer Res; 70(12); 4820–8. ©2010 AACR." @default.
- W2111781151 created "2016-06-24" @default.
- W2111781151 creator A5016251947 @default.
- W2111781151 creator A5061984381 @default.
- W2111781151 creator A5079451508 @default.
- W2111781151 date "2010-06-14" @default.
- W2111781151 modified "2023-10-03" @default.
- W2111781151 title "Myc-Induced MicroRNAs Integrate Myc-Mediated Cell Proliferation and Cell Fate" @default.
- W2111781151 cites W144423133 @default.
- W2111781151 cites W1543093074 @default.
- W2111781151 cites W1963735070 @default.
- W2111781151 cites W1964742508 @default.
- W2111781151 cites W1965254413 @default.
- W2111781151 cites W1973577899 @default.
- W2111781151 cites W1976874039 @default.
- W2111781151 cites W1977479343 @default.
- W2111781151 cites W1979843175 @default.
- W2111781151 cites W1982598635 @default.
- W2111781151 cites W1989617578 @default.
- W2111781151 cites W2004588189 @default.
- W2111781151 cites W2013444425 @default.
- W2111781151 cites W2015018301 @default.
- W2111781151 cites W2034203463 @default.
- W2111781151 cites W2034269086 @default.
- W2111781151 cites W2036534625 @default.
- W2111781151 cites W2043395027 @default.
- W2111781151 cites W2047816695 @default.
- W2111781151 cites W2057654378 @default.
- W2111781151 cites W2058451329 @default.
- W2111781151 cites W2060029740 @default.
- W2111781151 cites W2066909301 @default.
- W2111781151 cites W2074183372 @default.
- W2111781151 cites W2074873270 @default.
- W2111781151 cites W2077036618 @default.
- W2111781151 cites W2084780592 @default.
- W2111781151 cites W2085442947 @default.
- W2111781151 cites W2091851050 @default.
- W2111781151 cites W2096473000 @default.
- W2111781151 cites W2101904615 @default.
- W2111781151 cites W2105613536 @default.
- W2111781151 cites W2110446991 @default.
- W2111781151 cites W2114622275 @default.
- W2111781151 cites W2117255149 @default.
- W2111781151 cites W2130410032 @default.
- W2111781151 cites W2130979840 @default.
- W2111781151 cites W2138366746 @default.
- W2111781151 cites W2141128504 @default.
- W2111781151 cites W2157754963 @default.
- W2111781151 cites W2160425771 @default.
- W2111781151 cites W2162224376 @default.
- W2111781151 cites W2328777842 @default.
- W2111781151 cites W2910065277 @default.
- W2111781151 cites W3023299375 @default.
- W2111781151 doi "https://doi.org/10.1158/0008-5472.can-10-0659" @default.
- W2111781151 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2888768" @default.
- W2111781151 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20516112" @default.
- W2111781151 hasPublicationYear "2010" @default.
- W2111781151 type Work @default.
- W2111781151 sameAs 2111781151 @default.
- W2111781151 citedByCount "47" @default.
- W2111781151 countsByYear W21117811512012 @default.
- W2111781151 countsByYear W21117811512013 @default.
- W2111781151 countsByYear W21117811512014 @default.
- W2111781151 countsByYear W21117811512015 @default.
- W2111781151 countsByYear W21117811512016 @default.
- W2111781151 countsByYear W21117811512017 @default.
- W2111781151 countsByYear W21117811512018 @default.
- W2111781151 countsByYear W21117811512019 @default.
- W2111781151 countsByYear W21117811512021 @default.
- W2111781151 countsByYear W21117811512022 @default.
- W2111781151 countsByYear W21117811512023 @default.
- W2111781151 crossrefType "journal-article" @default.
- W2111781151 hasAuthorship W2111781151A5016251947 @default.
- W2111781151 hasAuthorship W2111781151A5061984381 @default.
- W2111781151 hasAuthorship W2111781151A5079451508 @default.
- W2111781151 hasBestOaLocation W21117811511 @default.
- W2111781151 hasConcept C104317684 @default.
- W2111781151 hasConcept C121608353 @default.
- W2111781151 hasConcept C145059251 @default.
- W2111781151 hasConcept C1491633281 @default.
- W2111781151 hasConcept C150194340 @default.
- W2111781151 hasConcept C163952510 @default.
- W2111781151 hasConcept C165864922 @default.
- W2111781151 hasConcept C179185449 @default.
- W2111781151 hasConcept C186310378 @default.
- W2111781151 hasConcept C2777609662 @default.
- W2111781151 hasConcept C39845236 @default.
- W2111781151 hasConcept C502942594 @default.
- W2111781151 hasConcept C54355233 @default.
- W2111781151 hasConcept C62112901 @default.
- W2111781151 hasConcept C62478195 @default.
- W2111781151 hasConcept C86339819 @default.
- W2111781151 hasConcept C86554907 @default.
- W2111781151 hasConcept C86803240 @default.
- W2111781151 hasConcept C95444343 @default.
- W2111781151 hasConcept C96232424 @default.
- W2111781151 hasConceptScore W2111781151C104317684 @default.
- W2111781151 hasConceptScore W2111781151C121608353 @default.