Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111789634> ?p ?o ?g. }
- W2111789634 abstract "This study explores whether meningioma expresses epidermal growth factor receptor (EGFR) and determines if there is a correlation between the WHO grade of this tumor and the degree of EGFR expression. Following institutional review board approval, 113 meningioma specimens from 89 patients were chosen. Of these, 85 were used for final analysis. After a blinded review, immunohistochemical stains for EGFR were performed. Staining intensity (SI) was scored on a scale 0-3 (from no staining to strong staining). Staining percentage of immunoreactive cells (SP) was scored 1-5 (from the least to the maximum percent of the specimen staining). Immunohistochemical score (IHS) was calculated as the product of SI and SP. Eighty-five samples of meningioma were classified in accordance with World Health Organization (WHO) criteria: benign 57/85 (67%), atypical 23/85 (27%), and malignant 5/85 (6%). The majority of samples demonstrated a moderate SI for EGFR. IHS for EGFR demonstrated a significant association between SI and histopathologic subtype. Also, there was a correlation between the SP and histopathologic subtype (p = 0.029). A significant association was determined when the benign and the atypical samples were compared to the malignant with respect to the SP (p = 0.009). While there was a range of the IHS for the benign and the atypical histologic subtypes, malignant tumors exhibited the lowest score and were statistically different from the benign and the atypical specimens (p < 0.001). To our knowledge, this represents the largest series of meningioma samples analyzed for EGFR expression reported in the literature. EGFR expression is greatest in benign meningiomas and may serve a potential target for therapeutic intervention with selective EGFR inhibitors." @default.
- W2111789634 created "2016-06-24" @default.
- W2111789634 creator A5003029195 @default.
- W2111789634 creator A5016048962 @default.
- W2111789634 creator A5016683007 @default.
- W2111789634 creator A5018435734 @default.
- W2111789634 creator A5043314766 @default.
- W2111789634 creator A5049018134 @default.
- W2111789634 creator A5052983963 @default.
- W2111789634 creator A5061721402 @default.
- W2111789634 creator A5066158171 @default.
- W2111789634 date "2010-05-30" @default.
- W2111789634 modified "2023-10-01" @default.
- W2111789634 title "Assessment of Epidermal Growth Factor Receptor (EGFR) expression in human meningioma" @default.
- W2111789634 cites W1914368755 @default.
- W2111789634 cites W1975422371 @default.
- W2111789634 cites W1976451653 @default.
- W2111789634 cites W1977964760 @default.
- W2111789634 cites W1983764841 @default.
- W2111789634 cites W1984155363 @default.
- W2111789634 cites W1996598425 @default.
- W2111789634 cites W2006423782 @default.
- W2111789634 cites W2007030561 @default.
- W2111789634 cites W2014896274 @default.
- W2111789634 cites W2016661084 @default.
- W2111789634 cites W2020600496 @default.
- W2111789634 cites W2035857297 @default.
- W2111789634 cites W2036363901 @default.
- W2111789634 cites W2040139345 @default.
- W2111789634 cites W2055800013 @default.
- W2111789634 cites W2058836795 @default.
- W2111789634 cites W2064047613 @default.
- W2111789634 cites W2076333218 @default.
- W2111789634 cites W2083243156 @default.
- W2111789634 cites W2085975603 @default.
- W2111789634 cites W2095472784 @default.
- W2111789634 cites W2096696911 @default.
- W2111789634 cites W2122961418 @default.
- W2111789634 cites W2125392826 @default.
- W2111789634 cites W2133453529 @default.
- W2111789634 cites W2149908785 @default.
- W2111789634 cites W2155384808 @default.
- W2111789634 cites W2158835756 @default.
- W2111789634 cites W2166702762 @default.
- W2111789634 cites W2325631775 @default.
- W2111789634 cites W3028358753 @default.
- W2111789634 cites W4253193915 @default.
- W2111789634 doi "https://doi.org/10.1186/1748-717x-5-46" @default.
- W2111789634 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2890616" @default.
- W2111789634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20509969" @default.
- W2111789634 hasPublicationYear "2010" @default.
- W2111789634 type Work @default.
- W2111789634 sameAs 2111789634 @default.
- W2111789634 citedByCount "35" @default.
- W2111789634 countsByYear W21117896342012 @default.
- W2111789634 countsByYear W21117896342013 @default.
- W2111789634 countsByYear W21117896342014 @default.
- W2111789634 countsByYear W21117896342015 @default.
- W2111789634 countsByYear W21117896342016 @default.
- W2111789634 countsByYear W21117896342017 @default.
- W2111789634 countsByYear W21117896342018 @default.
- W2111789634 countsByYear W21117896342019 @default.
- W2111789634 countsByYear W21117896342020 @default.
- W2111789634 countsByYear W21117896342021 @default.
- W2111789634 countsByYear W21117896342022 @default.
- W2111789634 countsByYear W21117896342023 @default.
- W2111789634 crossrefType "journal-article" @default.
- W2111789634 hasAuthorship W2111789634A5003029195 @default.
- W2111789634 hasAuthorship W2111789634A5016048962 @default.
- W2111789634 hasAuthorship W2111789634A5016683007 @default.
- W2111789634 hasAuthorship W2111789634A5018435734 @default.
- W2111789634 hasAuthorship W2111789634A5043314766 @default.
- W2111789634 hasAuthorship W2111789634A5049018134 @default.
- W2111789634 hasAuthorship W2111789634A5052983963 @default.
- W2111789634 hasAuthorship W2111789634A5061721402 @default.
- W2111789634 hasAuthorship W2111789634A5066158171 @default.
- W2111789634 hasBestOaLocation W21117896341 @default.
- W2111789634 hasConcept C126322002 @default.
- W2111789634 hasConcept C142724271 @default.
- W2111789634 hasConcept C170493617 @default.
- W2111789634 hasConcept C204232928 @default.
- W2111789634 hasConcept C2779160599 @default.
- W2111789634 hasConcept C2779438470 @default.
- W2111789634 hasConcept C3018264335 @default.
- W2111789634 hasConcept C71924100 @default.
- W2111789634 hasConcept C74864618 @default.
- W2111789634 hasConceptScore W2111789634C126322002 @default.
- W2111789634 hasConceptScore W2111789634C142724271 @default.
- W2111789634 hasConceptScore W2111789634C170493617 @default.
- W2111789634 hasConceptScore W2111789634C204232928 @default.
- W2111789634 hasConceptScore W2111789634C2779160599 @default.
- W2111789634 hasConceptScore W2111789634C2779438470 @default.
- W2111789634 hasConceptScore W2111789634C3018264335 @default.
- W2111789634 hasConceptScore W2111789634C71924100 @default.
- W2111789634 hasConceptScore W2111789634C74864618 @default.
- W2111789634 hasIssue "1" @default.
- W2111789634 hasLocation W21117896341 @default.
- W2111789634 hasLocation W21117896342 @default.
- W2111789634 hasLocation W21117896343 @default.
- W2111789634 hasLocation W21117896344 @default.