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• W2111792159 abstract "Objectives: We investigated whether the Na + -H + exchange inhibitor, HOE642 (Hoe), and/or the Na channel blocker, mexiletine (Mex), enhance a cardioprotective effect on St. Thomas’ Hospital cardioplegic solution (STS) to clarify the mechanism by which intracellular Na + is accumulated after cardioplegic arrest. Materials and Methods: Isolated working rat hearts were perfused with Krebs-Henseleit bicarbonate buffer (KHBB). The hearts were then arrested with STS and subjected to normothermic global ischemia (30 min). This was followed by Langendorff reperfusion (15 min) and then a working reperfusion (20 min). In study A, we added Hoe (5, 10, and 20 µM), Mex (70 µM), or a combination of Hoe (20 µM) and Mex (70 µM), to STS. In study B, we added Hoe (20 µM), Mex (70 µM), or a combination of Hoe (20 µM) and Mex (70 µM) to KHBB during the first 3 min of Langendorff reperfusion. Results: In study A, the addition of Hoe (10 and 20 µM) to STS showed a significantly greater postischemic recovery of cardiac output compared to the control group [63.1 ±5.7% (10 µM), 62.7× 4.7% (20 µM), and 55.5±4.6% (control), respectively]. The postischemic recovery of cardiac output was significantly greater in the group of the combined addition (Hoe and Mex) to STS than that in the control, 20 µM Hoe, 70 µM Mex groups [70.3±3.7% (Hoe and Mex), 55.5±4.6% (control), 62.7±4.7% (Hoe 20 µM), and 60.2±4.7% (Mex 70 µM), respectively]. The myocardial water content in the postischemic period was 565.1±29.1, 525.8±2.9, 509.4±19.6, and 532.2±20.1; it was 497.3±9.1 mL/100 g dry weight in the control; and 10 µM Hoe, 20 µM Hoe, and 70 µM Mex in the combined use groups. In study B, there was no significant difference in the postischemic recovery of cardiac output in all experimental groups. Conclusion: The combined use of the Na + -H + exchange inhibitor and Na + channel blocker during cardioplegia may achieve a superior cardioprotective effect on myocardial damage because of ischemia and reperfusion. (Ann Thorac Cardiovasc Surg 2007; 13: 301‐307)" @default.
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• W2111792159 date "2007-10-01" @default.
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• W2111792159 title "The effects of Na movement on surgical myocardial protection: the role of the Na+-H+ exchange system and Na-channel in the development of ischemia and reperfusion injury." @default.
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