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- W2111799237 abstract "Appending appropriate esters to anti-inflammatory compounds leads to monocyte/macrophage selectivity. This has been demonstrated in p38α MAP kinase in which we observe differential inhibition of phosphorylation of the substrate MAPKAPK2 in stimulated cells. This selectivity is due to differential expression of carboxylesterases within the cells, which cause the active form of the compounds to accumulate with the cells." @default.
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- W2111799237 date "2012-01-01" @default.
- W2111799237 modified "2023-09-26" @default.
- W2111799237 title "Monocyte and macrophage selective anti-inflammatory kinase inhibitors" @default.
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- W2111799237 doi "https://doi.org/10.1039/c2md20158e" @default.
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