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- W2111804172 abstract "Summary Cancer stem cells (CSC) have been identified in hematological malignancies and several solid cancers. Similar to physiological stem cells, CSC are capable of self‐renewal and differentiation and have the potential for indefinite proliferation, a function through which they may cause tumor growth. Although conventional anti‐cancer treatments might eradicate most malignant cells in a tumor, they are potentially ineffective against chemoresistant CSC, which may ultimately be responsible for recurrence and progression. Human malignant melanoma is a highly aggressive and drug‐resistant cancer. Detection of tumor heterogeneity, undifferentiated molecular signatures, and increased tumorigenicity of melanoma subsets with embryonic‐like differentiation plasticity strongly suggest the presence and involvement of malignant melanoma stem cells (MMSC) in the initiation and propagation of this malignancy. Here, we review these findings in the context of functional properties ascribed to melanocyte stem cells and CSC in other cancers. We discuss the association of deregulated signaling pathways, genomic instability, and vasculogenic mimicry phenomena observed in melanoma subpopulations in light of the CSC concept. We propose that a subset of MMSC may be responsible for melanoma therapy‐resistance, tumor invasiveness, and neoplastic progression and that targeted abrogation of a MMSC compartment could therefore ultimately lead to stable remissions and perhaps cures of metastatic melanoma." @default.
- W2111804172 created "2016-06-24" @default.
- W2111804172 creator A5059492810 @default.
- W2111804172 creator A5089843842 @default.
- W2111804172 date "2008-02-01" @default.
- W2111804172 modified "2023-10-16" @default.
- W2111804172 title "REVIEW ARTICLE: Cancer stem cells and human malignant melanoma" @default.
- W2111804172 cites W1483167997 @default.
- W2111804172 cites W1500827124 @default.
- W2111804172 cites W1506680628 @default.
- W2111804172 cites W1517940049 @default.
- W2111804172 cites W1520425169 @default.
- W2111804172 cites W1533067566 @default.
- W2111804172 cites W1651215666 @default.
- W2111804172 cites W1667206495 @default.
- W2111804172 cites W1679229092 @default.
- W2111804172 cites W1816761971 @default.
- W2111804172 cites W186536535 @default.
- W2111804172 cites W1919139351 @default.
- W2111804172 cites W1923913903 @default.
- W2111804172 cites W1951046932 @default.
- W2111804172 cites W1963652662 @default.
- W2111804172 cites W1965681567 @default.
- W2111804172 cites W1967656020 @default.
- W2111804172 cites W1971282078 @default.
- W2111804172 cites W1975025595 @default.
- W2111804172 cites W1976222351 @default.
- W2111804172 cites W1976447608 @default.
- W2111804172 cites W1979094948 @default.
- W2111804172 cites W1980332250 @default.
- W2111804172 cites W1981605211 @default.
- W2111804172 cites W1982408656 @default.
- W2111804172 cites W1982903815 @default.
- W2111804172 cites W1983014406 @default.
- W2111804172 cites W1984791357 @default.
- W2111804172 cites W1985594917 @default.
- W2111804172 cites W1987957447 @default.
- W2111804172 cites W1989121777 @default.
- W2111804172 cites W1989220451 @default.
- W2111804172 cites W1990574061 @default.
- W2111804172 cites W1990768206 @default.
- W2111804172 cites W1992077193 @default.
- W2111804172 cites W1995168697 @default.
- W2111804172 cites W1996067072 @default.
- W2111804172 cites W1997813173 @default.
- W2111804172 cites W1998811052 @default.
- W2111804172 cites W2001406361 @default.
- W2111804172 cites W2001461804 @default.
- W2111804172 cites W2001544973 @default.
- W2111804172 cites W2001957066 @default.
- W2111804172 cites W2002776129 @default.
- W2111804172 cites W2004426310 @default.
- W2111804172 cites W2006434892 @default.
- W2111804172 cites W2006765115 @default.
- W2111804172 cites W2009886857 @default.
- W2111804172 cites W2010297649 @default.
- W2111804172 cites W2011994267 @default.
- W2111804172 cites W2012573463 @default.
- W2111804172 cites W2012701739 @default.
- W2111804172 cites W2012962381 @default.
- W2111804172 cites W2013207349 @default.
- W2111804172 cites W2015009944 @default.
- W2111804172 cites W2015522967 @default.
- W2111804172 cites W2016886090 @default.
- W2111804172 cites W2016983859 @default.
- W2111804172 cites W2019931839 @default.
- W2111804172 cites W2020917997 @default.
- W2111804172 cites W2021054064 @default.
- W2111804172 cites W2023186669 @default.
- W2111804172 cites W2023187622 @default.
- W2111804172 cites W2023427658 @default.
- W2111804172 cites W2028811109 @default.
- W2111804172 cites W2029073164 @default.
- W2111804172 cites W2029231546 @default.
- W2111804172 cites W2030086669 @default.
- W2111804172 cites W2030943857 @default.
- W2111804172 cites W2031770999 @default.
- W2111804172 cites W2033042516 @default.
- W2111804172 cites W2033931866 @default.
- W2111804172 cites W2034030391 @default.
- W2111804172 cites W2034683528 @default.
- W2111804172 cites W2035464744 @default.
- W2111804172 cites W2035690311 @default.
- W2111804172 cites W2036008499 @default.
- W2111804172 cites W2039298921 @default.
- W2111804172 cites W2041552691 @default.
- W2111804172 cites W2044560586 @default.
- W2111804172 cites W2045577764 @default.
- W2111804172 cites W2051055358 @default.
- W2111804172 cites W2054170174 @default.
- W2111804172 cites W2057872890 @default.
- W2111804172 cites W2058723862 @default.
- W2111804172 cites W2061113194 @default.
- W2111804172 cites W2061943708 @default.
- W2111804172 cites W2062069198 @default.
- W2111804172 cites W2068289276 @default.
- W2111804172 cites W2070793750 @default.
- W2111804172 cites W2072042546 @default.