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- W2111806114 abstract "To the Editor. —The article by Gross et al, Prevention of Amphotericin B—Induced Rigors by Dantrolene that appeared in the August 1986 issue of theArchives 1 was of interest since it suggested a solution to a bothersome adverse effect of an increasingly used antifungal agent. Premedication regimens to control these reactions to amphotericin B may include acetaminophen, hydrocortisone, antihistamines, and phenothiazines, but their efficacy is uncertain and has never been demonstrated in prospective trials. Burke et al, in a small but randomized study, demonstrated that meperidine hydrochloride (Demerol), in doses of 50 mg or more, alleviate the chills and rigors associated with amphotericin B infusions. 2 Our anecdotal experience with meperidine agrees with Burke's findings, but there are occasional patients who do not respond to meperidine hydrochloride. Report of a Case. —We recently cared for a 32-year-old man with the acquired immunodeficiency syndrome (AIDS), complicated" @default.
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- W2111806114 date "1987-12-01" @default.
- W2111806114 modified "2023-09-24" @default.
- W2111806114 title "Dantrolene for amphotericin B-induced rigors" @default.
- W2111806114 cites W2087617103 @default.
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- W2111806114 doi "https://doi.org/10.1001/archinte.147.12.2220b" @default.
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