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• W2111812087 abstract "The aim of this study was to determine whether estrogen and/or raloxifene help to conserve bone mineral density (BMD) during moderate weight loss. Postmenopausal women (n = 68) participated in a 6-month weight loss program that consisted primarily of supervised exercise training. Another 26 women were studied over 6 months of weight stability. All participants were randomized to three treatment arms: placebo, raloxifene (60 mg/d), or hormone therapy (HT; conjugated estrogens, 0.625 mg/d; trimonthly medroxyprogesterone acetate, 5 mg/d for 13 d, for women with a uterus). Changes in body weight (mean ± se) averaged 0.8 ± 0.5 kg in the weight-stable group and −4.1 ± 0.4 kg in the weight loss group. Across all measured skeletal sites, average changes in BMD in weight stable women were −0.6 ± 1.1% (n = 7), 0.9 ± 0.6% (n = 9), and 3.0 ± 0.7% (n = 10) in the placebo, raloxifene, and HT groups, respectively; comparable BMD changes in the weight loss groups were −1.5 ± 0.5% (n = 22), −0.5 ± 0.5% (n = 23), and 1.1 ± 0.4% (n = 23). There were no significant interactions between weight loss and drug treatment on changes in BMD, but there were significant main effects of weight loss on lumbar spine (P = 0.022), total hip (P = 0.010), and trochanter BMD (P < 0.001). These findings suggest that weight loss, even when modest in magnitude and induced by exercise training, causes a reduction in BMD, particularly in women not taking raloxifene or HT. It is not known whether reductions in BMD of this magnitude increase the risk for osteoporotic fracture." @default.
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• W2111812087 date "2005-01-01" @default.
• W2111812087 modified "2023-10-10" @default.
• W2111812087 title "Protection of Bone Mass by Estrogens and Raloxifene during Exercise-Induced Weight Loss" @default.
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• W2111812087 doi "https://doi.org/10.1210/jc.2004-0275" @default.
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