Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111812811> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2111812811 endingPage "758" @default.
- W2111812811 startingPage "752" @default.
- W2111812811 abstract "1. The level of glycated haemoglobin (GHb) in diabetic rats was measured using a newly developed automatic high-performance liquid chromatography (HPLC) with a boronate affinity column that requires only 2.5 min per sample for analysis. 2. Levels of GHb were 2.7% in normal 7-week-old Sprague-Dawley rats. These levels increased gradually following the abrupt induction of hyperglycaemia by intravenous injection of streptozotocin (STZ), reaching a maximal level of 10.1% after 6 weeks. 3. Glycosylated haemoglobin (HbA1) levels measured by cation-exchange chromatography were also increased by STZ treatment, although HbA1 values were lower than GHb measured by affinity column HPLC. 4. In Wistar fatty rats, GHb levels declined gradually over 5 weeks following the administration of pioglitazone (0.75 or 2.25 mg/kg per day) as a food admixture, which reduced plasma glucose (PG) levels to normal levels within 1 week. Glycated haemoglobin levels after 5 weeks treatment with pioglitazone correlated better with the area under the curve for PG over the entire 5 week treatment period than with the PG level at the end of treatment. 5. In addition, GHb determined by affinity column HPLC correlated well with HbA1 measured by cation-exchange chromatography, although the GHb value was higher than the HbA1 value. 6. Glycated haemoglobin levels in db/db and KKAy mice were higher than those in control normoglycaemic animals and were also higher than HbA1 values measured by the cation-exchange method, although the two values did show good correlation. 7. These results indicate that the newly developed affinity column HPLC system is useful for evaluating total GHb levels in rats as an index of antidiabetic treatment." @default.
- W2111812811 created "2016-06-24" @default.
- W2111812811 creator A5007671862 @default.
- W2111812811 creator A5046543948 @default.
- W2111812811 creator A5050508325 @default.
- W2111812811 creator A5051815236 @default.
- W2111812811 creator A5056956711 @default.
- W2111812811 creator A5061732254 @default.
- W2111812811 creator A5086106763 @default.
- W2111812811 date "2003-09-29" @default.
- W2111812811 modified "2023-10-15" @default.
- W2111812811 title "Changes in glycated haemoglobin levels in diabetic rats measured with an automatic affinity HPLC" @default.
- W2111812811 cites W1892020495 @default.
- W2111812811 cites W1923494636 @default.
- W2111812811 cites W1966449739 @default.
- W2111812811 cites W1988249849 @default.
- W2111812811 cites W2034799247 @default.
- W2111812811 cites W2048291810 @default.
- W2111812811 cites W2059089196 @default.
- W2111812811 cites W2078873904 @default.
- W2111812811 cites W2106606181 @default.
- W2111812811 cites W2112046979 @default.
- W2111812811 cites W2113760061 @default.
- W2111812811 cites W4237930451 @default.
- W2111812811 cites W96696524 @default.
- W2111812811 doi "https://doi.org/10.1046/j.1440-1681.2003.03902.x" @default.
- W2111812811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14516414" @default.
- W2111812811 hasPublicationYear "2003" @default.
- W2111812811 type Work @default.
- W2111812811 sameAs 2111812811 @default.
- W2111812811 citedByCount "11" @default.
- W2111812811 countsByYear W21118128112015 @default.
- W2111812811 countsByYear W21118128112016 @default.
- W2111812811 countsByYear W21118128112018 @default.
- W2111812811 countsByYear W21118128112023 @default.
- W2111812811 crossrefType "journal-article" @default.
- W2111812811 hasAuthorship W2111812811A5007671862 @default.
- W2111812811 hasAuthorship W2111812811A5046543948 @default.
- W2111812811 hasAuthorship W2111812811A5050508325 @default.
- W2111812811 hasAuthorship W2111812811A5051815236 @default.
- W2111812811 hasAuthorship W2111812811A5056956711 @default.
- W2111812811 hasAuthorship W2111812811A5061732254 @default.
- W2111812811 hasAuthorship W2111812811A5086106763 @default.
- W2111812811 hasConcept C126322002 @default.
- W2111812811 hasConcept C134018914 @default.
- W2111812811 hasConcept C179998833 @default.
- W2111812811 hasConcept C185592680 @default.
- W2111812811 hasConcept C2777180221 @default.
- W2111812811 hasConcept C2777538456 @default.
- W2111812811 hasConcept C2778384471 @default.
- W2111812811 hasConcept C2779280383 @default.
- W2111812811 hasConcept C2909938374 @default.
- W2111812811 hasConcept C43617362 @default.
- W2111812811 hasConcept C555293320 @default.
- W2111812811 hasConcept C71924100 @default.
- W2111812811 hasConceptScore W2111812811C126322002 @default.
- W2111812811 hasConceptScore W2111812811C134018914 @default.
- W2111812811 hasConceptScore W2111812811C179998833 @default.
- W2111812811 hasConceptScore W2111812811C185592680 @default.
- W2111812811 hasConceptScore W2111812811C2777180221 @default.
- W2111812811 hasConceptScore W2111812811C2777538456 @default.
- W2111812811 hasConceptScore W2111812811C2778384471 @default.
- W2111812811 hasConceptScore W2111812811C2779280383 @default.
- W2111812811 hasConceptScore W2111812811C2909938374 @default.
- W2111812811 hasConceptScore W2111812811C43617362 @default.
- W2111812811 hasConceptScore W2111812811C555293320 @default.
- W2111812811 hasConceptScore W2111812811C71924100 @default.
- W2111812811 hasIssue "10" @default.
- W2111812811 hasLocation W21118128111 @default.
- W2111812811 hasLocation W21118128112 @default.
- W2111812811 hasOpenAccess W2111812811 @default.
- W2111812811 hasPrimaryLocation W21118128111 @default.
- W2111812811 hasRelatedWork W2085410812 @default.
- W2111812811 hasRelatedWork W2286197530 @default.
- W2111812811 hasRelatedWork W2377249510 @default.
- W2111812811 hasRelatedWork W2386127892 @default.
- W2111812811 hasRelatedWork W2418292593 @default.
- W2111812811 hasRelatedWork W2793713272 @default.
- W2111812811 hasRelatedWork W3023648580 @default.
- W2111812811 hasRelatedWork W4241268257 @default.
- W2111812811 hasRelatedWork W4248649765 @default.
- W2111812811 hasRelatedWork W2598442426 @default.
- W2111812811 hasVolume "30" @default.
- W2111812811 isParatext "false" @default.
- W2111812811 isRetracted "false" @default.
- W2111812811 magId "2111812811" @default.
- W2111812811 workType "article" @default.