Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111826228> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2111826228 abstract "The transport of small molecules, peptides and proteins via the olfactory epithelium and along olfactory and trigeminal nerve pathways from the nasal cavity to the brain is very well known and clinically established for central nervous system (CNS) active drugs like oxytocin, sumatriptan or insulin. Insulin is a clinically well-established biopharmaceutical with a validated function in cognition. Central supply with insulin via intranasal administration improves cognition in animal models and in human, making insulin a so-called cognitive enhancer. Furthermore, dysregulation of insulin is implicated in the pathogenesis of Alzheimer’s disease, which is associated with lower levels of insulin in the cerebrospinal fluid and is involved in amyloid-beta (Ab) regulation. Clinical trials with intranasal insulin implicate positive effects on learning and memory, but a massive lack of pharmacokinetic and efficacy data hamper a pharmacokinetic – pharmcodynamic relation and a possible clinical development as cognition enhancer. A lack of such data also prevents resolving the mechanisms involved in directing insulin to the central or to the peripheral compartment. Here we discuss the basic mechanism of Nose-to-Brain delivery, evidences for intranasal insulin as cognition enhancer, medical devices for intranasal delivery and safety aspects." @default.
- W2111826228 created "2016-06-24" @default.
- W2111826228 creator A5002951388 @default.
- W2111826228 creator A5010063210 @default.
- W2111826228 creator A5047124498 @default.
- W2111826228 creator A5087634155 @default.
- W2111826228 date "2015-09-05" @default.
- W2111826228 modified "2023-10-03" @default.
- W2111826228 title "Nose-to-Brain delivery of insulin for Alzheimer’s disease" @default.
- W2111826228 cites W1538091406 @default.
- W2111826228 cites W1588150800 @default.
- W2111826228 cites W1969006205 @default.
- W2111826228 cites W1975060067 @default.
- W2111826228 cites W1980439325 @default.
- W2111826228 cites W2011430246 @default.
- W2111826228 cites W2044682044 @default.
- W2111826228 cites W2063739175 @default.
- W2111826228 cites W2084959598 @default.
- W2111826228 cites W2132047707 @default.
- W2111826228 cites W2136927925 @default.
- W2111826228 cites W2156770885 @default.
- W2111826228 cites W2163562064 @default.
- W2111826228 cites W2318560569 @default.
- W2111826228 doi "https://doi.org/10.5599/admet.3.3.184" @default.
- W2111826228 hasPublicationYear "2015" @default.
- W2111826228 type Work @default.
- W2111826228 sameAs 2111826228 @default.
- W2111826228 citedByCount "20" @default.
- W2111826228 countsByYear W21118262282016 @default.
- W2111826228 countsByYear W21118262282017 @default.
- W2111826228 countsByYear W21118262282018 @default.
- W2111826228 countsByYear W21118262282019 @default.
- W2111826228 countsByYear W21118262282021 @default.
- W2111826228 countsByYear W21118262282022 @default.
- W2111826228 countsByYear W21118262282023 @default.
- W2111826228 crossrefType "journal-article" @default.
- W2111826228 hasAuthorship W2111826228A5002951388 @default.
- W2111826228 hasAuthorship W2111826228A5010063210 @default.
- W2111826228 hasAuthorship W2111826228A5047124498 @default.
- W2111826228 hasAuthorship W2111826228A5087634155 @default.
- W2111826228 hasBestOaLocation W21118262281 @default.
- W2111826228 hasConcept C105702510 @default.
- W2111826228 hasConcept C134018914 @default.
- W2111826228 hasConcept C15744967 @default.
- W2111826228 hasConcept C169760540 @default.
- W2111826228 hasConcept C169900460 @default.
- W2111826228 hasConcept C2778402981 @default.
- W2111826228 hasConcept C2778801703 @default.
- W2111826228 hasConcept C2779306644 @default.
- W2111826228 hasConcept C529278444 @default.
- W2111826228 hasConcept C71924100 @default.
- W2111826228 hasConcept C85663871 @default.
- W2111826228 hasConcept C98274493 @default.
- W2111826228 hasConceptScore W2111826228C105702510 @default.
- W2111826228 hasConceptScore W2111826228C134018914 @default.
- W2111826228 hasConceptScore W2111826228C15744967 @default.
- W2111826228 hasConceptScore W2111826228C169760540 @default.
- W2111826228 hasConceptScore W2111826228C169900460 @default.
- W2111826228 hasConceptScore W2111826228C2778402981 @default.
- W2111826228 hasConceptScore W2111826228C2778801703 @default.
- W2111826228 hasConceptScore W2111826228C2779306644 @default.
- W2111826228 hasConceptScore W2111826228C529278444 @default.
- W2111826228 hasConceptScore W2111826228C71924100 @default.
- W2111826228 hasConceptScore W2111826228C85663871 @default.
- W2111826228 hasConceptScore W2111826228C98274493 @default.
- W2111826228 hasIssue "3" @default.
- W2111826228 hasLocation W21118262281 @default.
- W2111826228 hasLocation W21118262282 @default.
- W2111826228 hasLocation W21118262283 @default.
- W2111826228 hasLocation W21118262284 @default.
- W2111826228 hasOpenAccess W2111826228 @default.
- W2111826228 hasPrimaryLocation W21118262281 @default.
- W2111826228 hasRelatedWork W2001525797 @default.
- W2111826228 hasRelatedWork W2010902678 @default.
- W2111826228 hasRelatedWork W2074117732 @default.
- W2111826228 hasRelatedWork W2229489465 @default.
- W2111826228 hasRelatedWork W2339057853 @default.
- W2111826228 hasRelatedWork W2386454361 @default.
- W2111826228 hasRelatedWork W2902940972 @default.
- W2111826228 hasRelatedWork W2989258648 @default.
- W2111826228 hasRelatedWork W3195904844 @default.
- W2111826228 hasRelatedWork W4213149191 @default.
- W2111826228 hasVolume "3" @default.
- W2111826228 isParatext "false" @default.
- W2111826228 isRetracted "false" @default.
- W2111826228 magId "2111826228" @default.
- W2111826228 workType "article" @default.