FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111841686> ?p ?o ?g. }

• W2111841686 abstract "Whereas estradiol prevents fatty streak deposit in immunocompetent apoE-/- or LDLr-/- mice, it is totally ineffective in immunodeficient mice, underlining the key role of immunoinflammation in this effect. In the present work, the role of several major pro- and antiinflammatory cytokines involved in the atheromatous process was evaluated in the effect of estradiol on fatty streak constitution.The preventive effect of estradiol was fully maintained in LDLr-/- mice grafted with bone marrow from either IFN-gamma or interleukin (IL)-12-deficient mice, showing that this beneficial effect was not mediated through a specific decrease in the production of these 2 proinflammatory cytokines. Furthermore, IL-10-/- apoE-/- mice remained protected by estradiol, excluding a significant contribution of this antiinflammatory cytokine. In contrast, the protective effect of estradiol was (1) associated with enhanced aortic expression of TGF-beta1 in apoE-/- mice during early steps of atherogenesis; (2) abolished and even reversed in apoE-/- mice administered with a neutralizing anti-TGF-beta antibody; (3) abolished in LDLr-/- mice grafted with bone marrow from Smad3-deficient mice.The status of the TGF-beta pathway crucially determines the antiatherogenic effect of estradiol in hypercholesterolemic mice, whereas neither IFN-gamma, IL-12, nor IL-10 are specifically involved in this protection." @default.
• W2111841686 created "2016-06-24" @default.
• W2111841686 creator A5024400535 @default.
• W2111841686 creator A5037421002 @default.
• W2111841686 creator A5040313714 @default.
• W2111841686 creator A5043815002 @default.
• W2111841686 creator A5046142639 @default.
• W2111841686 creator A5047653403 @default.
• W2111841686 creator A5056347497 @default.
• W2111841686 creator A5063953662 @default.
• W2111841686 creator A5077469809 @default.
• W2111841686 date "2007-10-01" @default.
• W2111841686 modified "2023-10-16" @default.
• W2111841686 title "Transforming Growth Factor Activity Is a Key Determinant for the Effect of Estradiol on Fatty Streak Deposit in Hypercholesterolemic Mice" @default.
• W2111841686 cites W1593442063 @default.
• W2111841686 cites W1897269170 @default.
• W2111841686 cites W1973278785 @default.
• W2111841686 cites W1975548084 @default.
• W2111841686 cites W1987415108 @default.
• W2111841686 cites W1992234633 @default.
• W2111841686 cites W2000410035 @default.
• W2111841686 cites W2001529435 @default.
• W2111841686 cites W2026428548 @default.
• W2111841686 cites W2031145414 @default.
• W2111841686 cites W2035763668 @default.
• W2111841686 cites W2059862716 @default.
• W2111841686 cites W2060179744 @default.
• W2111841686 cites W2066963386 @default.
• W2111841686 cites W2071041688 @default.
• W2111841686 cites W2075181613 @default.
• W2111841686 cites W2075566426 @default.
• W2111841686 cites W2084052630 @default.
• W2111841686 cites W2092505499 @default.
• W2111841686 cites W2093165931 @default.
• W2111841686 cites W2096251327 @default.
• W2111841686 cites W2111434189 @default.
• W2111841686 cites W2113183078 @default.
• W2111841686 cites W2113264115 @default.
• W2111841686 cites W2123917725 @default.
• W2111841686 cites W2127899118 @default.
• W2111841686 cites W2131958114 @default.
• W2111841686 cites W2154356580 @default.
• W2111841686 cites W2159218480 @default.
• W2111841686 cites W2161690689 @default.
• W2111841686 cites W2162694734 @default.
• W2111841686 cites W2164449928 @default.
• W2111841686 cites W2165463540 @default.
• W2111841686 cites W2169022524 @default.
• W2111841686 cites W2169844701 @default.
• W2111841686 cites W239859119 @default.
• W2111841686 doi "https://doi.org/10.1161/atvbaha.107.150300" @default.
• W2111841686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17690314" @default.
• W2111841686 hasPublicationYear "2007" @default.
• W2111841686 type Work @default.
• W2111841686 sameAs 2111841686 @default.
• W2111841686 citedByCount "13" @default.
• W2111841686 countsByYear W21118416862012 @default.
• W2111841686 countsByYear W21118416862014 @default.
• W2111841686 countsByYear W21118416862015 @default.
• W2111841686 countsByYear W21118416862016 @default.
• W2111841686 countsByYear W21118416862020 @default.
• W2111841686 crossrefType "journal-article" @default.
• W2111841686 hasAuthorship W2111841686A5024400535 @default.
• W2111841686 hasAuthorship W2111841686A5037421002 @default.
• W2111841686 hasAuthorship W2111841686A5040313714 @default.
• W2111841686 hasAuthorship W2111841686A5043815002 @default.
• W2111841686 hasAuthorship W2111841686A5046142639 @default.
• W2111841686 hasAuthorship W2111841686A5047653403 @default.
• W2111841686 hasAuthorship W2111841686A5056347497 @default.
• W2111841686 hasAuthorship W2111841686A5063953662 @default.
• W2111841686 hasAuthorship W2111841686A5077469809 @default.
• W2111841686 hasBestOaLocation W21118416861 @default.
• W2111841686 hasConcept C126322002 @default.
• W2111841686 hasConcept C134018914 @default.
• W2111841686 hasConcept C164027704 @default.
• W2111841686 hasConcept C185592680 @default.
• W2111841686 hasConcept C2776914184 @default.
• W2111841686 hasConcept C2778116356 @default.
• W2111841686 hasConcept C2778163477 @default.
• W2111841686 hasConcept C2778690821 @default.
• W2111841686 hasConcept C2779134260 @default.
• W2111841686 hasConcept C2780007613 @default.
• W2111841686 hasConcept C2780072125 @default.
• W2111841686 hasConcept C43554185 @default.
• W2111841686 hasConcept C57089818 @default.
• W2111841686 hasConcept C71924100 @default.
• W2111841686 hasConcept C86803240 @default.
• W2111841686 hasConceptScore W2111841686C126322002 @default.
• W2111841686 hasConceptScore W2111841686C134018914 @default.
• W2111841686 hasConceptScore W2111841686C164027704 @default.
• W2111841686 hasConceptScore W2111841686C185592680 @default.
• W2111841686 hasConceptScore W2111841686C2776914184 @default.
• W2111841686 hasConceptScore W2111841686C2778116356 @default.
• W2111841686 hasConceptScore W2111841686C2778163477 @default.
• W2111841686 hasConceptScore W2111841686C2778690821 @default.
• W2111841686 hasConceptScore W2111841686C2779134260 @default.
• W2111841686 hasConceptScore W2111841686C2780007613 @default.
• W2111841686 hasConceptScore W2111841686C2780072125 @default.
• W2111841686 hasConceptScore W2111841686C43554185 @default.
• W2111841686 hasConceptScore W2111841686C57089818 @default.

• next