FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111845194> ?p ?o ?g. }

• W2111845194 endingPage "169" @default.
• W2111845194 startingPage "169" @default.
• W2111845194 abstract "Several studies in Drosophila have shown excessive movement of retrogenes from the X chromosome to autosomes, and that these genes are frequently expressed in the testis. This phenomenon has led to several hypotheses invoking natural selection as the process driving male-biased genes to the autosomes. Metta and Schlötterer (BMC Evol Biol 2010, 10:114) analyzed a set of retrogenes where the parental gene has been subsequently lost. They assumed that this class of retrogenes replaced the ancestral functions of the parental gene, and reported that these retrogenes, although mostly originating from movement out of the X chromosome, showed female-biased or unbiased expression. These observations led the authors to suggest that selective forces (such as meiotic sex chromosome inactivation and sexual antagonism) were not responsible for the observed pattern of retrogene movement out of the X chromosome. We reanalyzed the dataset published by Metta and Schlötterer and found several issues that led us to a different conclusion. In particular, Metta and Schlötterer used a dataset combined with expression data in which significant sex-biased expression is not detectable. First, the authors used a segmental dataset where the genes selected for analysis were less testis-biased in expression than those that were excluded from the study. Second, sex-biased expression was defined by comparing male and female whole-body data and not the expression of these genes in gonadal tissues. This approach significantly reduces the probability of detecting sex-biased expressed genes, which explains why the vast majority of the genes analyzed (parental and retrogenes) were equally expressed in both males and females. Third, the female-biased expression observed by Metta and Schlötterer is mostly found for parental genes located on the X chromosome, which is known to be enriched with genes with female-biased expression. Fourth, using additional gonad expression data, we found that autosomal genes analyzed by Metta and Schlötterer are less up regulated in ovaries and have higher chance to be expressed in meiotic cells of spermatogenesis when compared to X-linked genes. The criteria used to select retrogenes and the sex-biased expression data based on whole adult flies generated a segmental dataset of female-biased and unbiased expressed genes that was unable to detect the higher propensity of autosomal retrogenes to be expressed in males. Thus, there is no support for the authors’ view that the movement of new retrogenes, which originated from X-linked parental genes, was not driven by selection. Therefore, selection-based genetic models remain the most parsimonious explanations for the observed chromosomal distribution of retrogenes." @default.
• W2111845194 created "2016-06-24" @default.
• W2111845194 creator A5007531675 @default.
• W2111845194 creator A5012845493 @default.
• W2111845194 creator A5013678749 @default.
• W2111845194 creator A5032424158 @default.
• W2111845194 creator A5037432233 @default.
• W2111845194 creator A5068729286 @default.
• W2111845194 creator A5077864427 @default.
• W2111845194 date "2012-01-01" @default.
• W2111845194 modified "2023-10-05" @default.
• W2111845194 title "Segmental dataset and whole body expression data do not support the hypothesis that non-random movement is an intrinsic property of Drosophila retrogenes" @default.
• W2111845194 cites W1965939735 @default.
• W2111845194 cites W1968621706 @default.
• W2111845194 cites W1970551030 @default.
• W2111845194 cites W1988830508 @default.
• W2111845194 cites W1991531009 @default.
• W2111845194 cites W1993827187 @default.
• W2111845194 cites W2000860895 @default.
• W2111845194 cites W2022651039 @default.
• W2111845194 cites W2027752792 @default.
• W2111845194 cites W2035789753 @default.
• W2111845194 cites W2041358828 @default.
• W2111845194 cites W2042661483 @default.
• W2111845194 cites W2051147560 @default.
• W2111845194 cites W2053194356 @default.
• W2111845194 cites W2055841741 @default.
• W2111845194 cites W2057277929 @default.
• W2111845194 cites W2086152457 @default.
• W2111845194 cites W2098274585 @default.
• W2111845194 cites W2100518496 @default.
• W2111845194 cites W2104698675 @default.
• W2111845194 cites W2109501723 @default.
• W2111845194 cites W2113623526 @default.
• W2111845194 cites W2122764009 @default.
• W2111845194 cites W2126334360 @default.
• W2111845194 cites W2130925862 @default.
• W2111845194 cites W2131053764 @default.
• W2111845194 cites W2131160279 @default.
• W2111845194 cites W2139067647 @default.
• W2111845194 cites W2151374010 @default.
• W2111845194 cites W2163965551 @default.
• W2111845194 cites W2165780130 @default.
• W2111845194 cites W2167496283 @default.
• W2111845194 cites W2172161352 @default.
• W2111845194 cites W4249939244 @default.
• W2111845194 doi "https://doi.org/10.1186/1471-2148-12-169" @default.
• W2111845194 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3532075" @default.
• W2111845194 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22950647" @default.
• W2111845194 hasPublicationYear "2012" @default.
• W2111845194 type Work @default.
• W2111845194 sameAs 2111845194 @default.
• W2111845194 citedByCount "1" @default.
• W2111845194 countsByYear W21118451942013 @default.
• W2111845194 crossrefType "journal-article" @default.
• W2111845194 hasAuthorship W2111845194A5007531675 @default.
• W2111845194 hasAuthorship W2111845194A5012845493 @default.
• W2111845194 hasAuthorship W2111845194A5013678749 @default.
• W2111845194 hasAuthorship W2111845194A5032424158 @default.
• W2111845194 hasAuthorship W2111845194A5037432233 @default.
• W2111845194 hasAuthorship W2111845194A5068729286 @default.
• W2111845194 hasAuthorship W2111845194A5077864427 @default.
• W2111845194 hasBestOaLocation W21118451941 @default.
• W2111845194 hasConcept C104317684 @default.
• W2111845194 hasConcept C134925867 @default.
• W2111845194 hasConcept C148196450 @default.
• W2111845194 hasConcept C150194340 @default.
• W2111845194 hasConcept C2776041557 @default.
• W2111845194 hasConcept C30481170 @default.
• W2111845194 hasConcept C35158069 @default.
• W2111845194 hasConcept C36217612 @default.
• W2111845194 hasConcept C4323932 @default.
• W2111845194 hasConcept C54355233 @default.
• W2111845194 hasConcept C78458016 @default.
• W2111845194 hasConcept C86803240 @default.
• W2111845194 hasConcept C92509807 @default.
• W2111845194 hasConceptScore W2111845194C104317684 @default.
• W2111845194 hasConceptScore W2111845194C134925867 @default.
• W2111845194 hasConceptScore W2111845194C148196450 @default.
• W2111845194 hasConceptScore W2111845194C150194340 @default.
• W2111845194 hasConceptScore W2111845194C2776041557 @default.
• W2111845194 hasConceptScore W2111845194C30481170 @default.
• W2111845194 hasConceptScore W2111845194C35158069 @default.
• W2111845194 hasConceptScore W2111845194C36217612 @default.
• W2111845194 hasConceptScore W2111845194C4323932 @default.
• W2111845194 hasConceptScore W2111845194C54355233 @default.
• W2111845194 hasConceptScore W2111845194C78458016 @default.
• W2111845194 hasConceptScore W2111845194C86803240 @default.
• W2111845194 hasConceptScore W2111845194C92509807 @default.
• W2111845194 hasIssue "1" @default.
• W2111845194 hasLocation W21118451941 @default.
• W2111845194 hasLocation W21118451942 @default.
• W2111845194 hasLocation W21118451943 @default.
• W2111845194 hasLocation W21118451944 @default.
• W2111845194 hasOpenAccess W2111845194 @default.
• W2111845194 hasPrimaryLocation W21118451941 @default.
• W2111845194 hasRelatedWork W1977541555 @default.
• W2111845194 hasRelatedWork W1994420360 @default.

• next