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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111858371> ?p ?o ?g. }

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• W2111858371 abstract "A biaryl pyridylfuran P(3) substituent on the hydroxyethylene isostere scaffold affords HIV protease inhibitors (PI's) with picomolar (IC(50)) potency against the protease enzymes from PI-resistant HIV-1 strains. Inclusion of a gem-dimethyl substituent afforded compound 3 with 100% oral bioavailability (dogs) and more than double the t(1/2) of indinavir. Inhibition of multiple P450 isoforms is dependent on the regiochemistry of the pyridyl nitrogen in these compounds." @default.
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• W2111858371 date "2003-08-01" @default.
• W2111858371 modified "2023-10-12" @default.
• W2111858371 title "HIV protease inhibitors with picomolar potency against PI-Resistant HIV-1 by extension of the P3 substituent" @default.
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• W2111858371 doi "https://doi.org/10.1016/s0960-894x(03)00475-x" @default.
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