Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111888586> ?p ?o ?g. }
- W2111888586 endingPage "1015" @default.
- W2111888586 startingPage "1005" @default.
- W2111888586 abstract "The aim of this study is to investigate whether AMP-activated protein kinase α2 (AMPKα2) is essential for wolfberry's protective effects on mitochondrial dysfunction and subsequent hepatic steatosis in mice.Six-week-old male AMPKα2 knockout mice and genetic background C57BL/6J (B6) mice were fed a control, high-fat diet (HD, 45% (kilocalorie) fat), and/or HD with 5% (kilocalarie) wolfberry diets for 18 wk. At termination, blood and liver tissues were sampled for analysis by ELISA, HPLC, microscopy, real-time PCR, and Western blot. HD lowered hepatic lutein and zeaxanthin contents, inhibited protein expression of β,β-carotene 9',10'-oxygenase 2 (BCO2) and heat shock protein 60 in mitochondria, increased reactive oxygen species level, and suppressed mitophagy and mitochondrial biogenesis as determined by accumulation of p62, inhibited phosphorylation of Unc-51-like kinase 1 on Ser555, and declined expression of peroxisome proliferator-activated receptor γ coactivator 1 α, resulting in hepatic steatosis in B6 and knockout mice. Dietary wolfberry elevated the xanthophyll concentrations and enhanced expression of BCO2 and heat shock protein 60, attenuated mitochondrial oxidative stress, activated AMPKα2, potentiated mitophagy and mitochondrial biogenesis, and enhanced lipid oxidation and secretion in the liver of B6 mice.Dietary wolfberry selectively activated AMPKα2, which resulted in enhanced mitochondrial biogenesis and potentiated mitophagy, leading to the prevention of hepatic steatosis in obese mice." @default.
- W2111888586 created "2016-06-24" @default.
- W2111888586 creator A5011573803 @default.
- W2111888586 creator A5011889472 @default.
- W2111888586 creator A5017782703 @default.
- W2111888586 creator A5031510233 @default.
- W2111888586 creator A5031686888 @default.
- W2111888586 creator A5034755663 @default.
- W2111888586 creator A5051879886 @default.
- W2111888586 creator A5052657579 @default.
- W2111888586 creator A5068451283 @default.
- W2111888586 creator A5076818830 @default.
- W2111888586 creator A5076910927 @default.
- W2111888586 date "2014-01-22" @default.
- W2111888586 modified "2023-10-14" @default.
- W2111888586 title "Wolfberries potentiate mitophagy and enhance mitochondrial biogenesis leading to prevention of hepatic steatosis in obese mice: The role of AMP-activated protein kinase α2 subunit" @default.
- W2111888586 cites W1566946085 @default.
- W2111888586 cites W1876043561 @default.
- W2111888586 cites W1963810838 @default.
- W2111888586 cites W1968743437 @default.
- W2111888586 cites W1986810494 @default.
- W2111888586 cites W1999646918 @default.
- W2111888586 cites W2007415406 @default.
- W2111888586 cites W2008777641 @default.
- W2111888586 cites W2010524294 @default.
- W2111888586 cites W2027969289 @default.
- W2111888586 cites W2031434506 @default.
- W2111888586 cites W2032878070 @default.
- W2111888586 cites W2034218807 @default.
- W2111888586 cites W2038007890 @default.
- W2111888586 cites W2045984716 @default.
- W2111888586 cites W2051055607 @default.
- W2111888586 cites W2052248930 @default.
- W2111888586 cites W2060663196 @default.
- W2111888586 cites W2060836453 @default.
- W2111888586 cites W2072997880 @default.
- W2111888586 cites W2078739475 @default.
- W2111888586 cites W2083139002 @default.
- W2111888586 cites W2085128107 @default.
- W2111888586 cites W2087829753 @default.
- W2111888586 cites W2094296585 @default.
- W2111888586 cites W2097533439 @default.
- W2111888586 cites W2101290541 @default.
- W2111888586 cites W2103659405 @default.
- W2111888586 cites W2109034822 @default.
- W2111888586 cites W2112317454 @default.
- W2111888586 cites W2112688610 @default.
- W2111888586 cites W2113649834 @default.
- W2111888586 cites W2116562304 @default.
- W2111888586 cites W2118819459 @default.
- W2111888586 cites W2119270583 @default.
- W2111888586 cites W2131007152 @default.
- W2111888586 cites W2134989487 @default.
- W2111888586 cites W2136917561 @default.
- W2111888586 cites W2144727133 @default.
- W2111888586 cites W2152311269 @default.
- W2111888586 cites W2154104081 @default.
- W2111888586 cites W2156090275 @default.
- W2111888586 cites W2160615487 @default.
- W2111888586 doi "https://doi.org/10.1002/mnfr.201300186" @default.
- W2111888586 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24449471" @default.
- W2111888586 hasPublicationYear "2014" @default.
- W2111888586 type Work @default.
- W2111888586 sameAs 2111888586 @default.
- W2111888586 citedByCount "24" @default.
- W2111888586 countsByYear W21118885862014 @default.
- W2111888586 countsByYear W21118885862015 @default.
- W2111888586 countsByYear W21118885862016 @default.
- W2111888586 countsByYear W21118885862017 @default.
- W2111888586 countsByYear W21118885862018 @default.
- W2111888586 countsByYear W21118885862019 @default.
- W2111888586 countsByYear W21118885862020 @default.
- W2111888586 countsByYear W21118885862021 @default.
- W2111888586 countsByYear W21118885862022 @default.
- W2111888586 countsByYear W21118885862023 @default.
- W2111888586 crossrefType "journal-article" @default.
- W2111888586 hasAuthorship W2111888586A5011573803 @default.
- W2111888586 hasAuthorship W2111888586A5011889472 @default.
- W2111888586 hasAuthorship W2111888586A5017782703 @default.
- W2111888586 hasAuthorship W2111888586A5031510233 @default.
- W2111888586 hasAuthorship W2111888586A5031686888 @default.
- W2111888586 hasAuthorship W2111888586A5034755663 @default.
- W2111888586 hasAuthorship W2111888586A5051879886 @default.
- W2111888586 hasAuthorship W2111888586A5052657579 @default.
- W2111888586 hasAuthorship W2111888586A5068451283 @default.
- W2111888586 hasAuthorship W2111888586A5076818830 @default.
- W2111888586 hasAuthorship W2111888586A5076910927 @default.
- W2111888586 hasConcept C126322002 @default.
- W2111888586 hasConcept C134018914 @default.
- W2111888586 hasConcept C184235292 @default.
- W2111888586 hasConcept C185592680 @default.
- W2111888586 hasConcept C190283241 @default.
- W2111888586 hasConcept C203522944 @default.
- W2111888586 hasConcept C2776175330 @default.
- W2111888586 hasConcept C2776780712 @default.
- W2111888586 hasConcept C2776804853 @default.
- W2111888586 hasConcept C2777229759 @default.
- W2111888586 hasConcept C2779324830 @default.