FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111911402> ?p ?o ?g. }

• W2111911402 abstract "Retinoids have been studied extensively for their potential as therapeutic and chemopreventive agents for a variety of cancers, including nonmelanoma skin cancer (NMSC). Despite their use for many years, the mechanism of action of retinoids in the prevention of NMSC is still unclear. In this study we have attempted to understand the chemopreventive mechanism of all-trans retinoic acid (ATRA), a primary biologically active retinoid, in order to more efficiently utilize retinoids in the clinic.We have used the 2-stage dimethylbenzanthracene (DMBA)/12-O-tetradecanoylphorbol-13-acetate (TPA) mouse skin carcinogenesis model to investigate the chemopreventive effects of ATRA. We have compared the gene expression profiles of control skin to skin subjected to the 2-stage protocol, with or without ATRA, using Affymetrix 430 2.0 DNA microarrays. Approximately 49% of the genes showing altered expression with TPA treatment are conversely affected when ATRA is co-administered. The activity of these genes, which we refer to as 'counter-regulated', may contribute to chemoprevention by ATRA. The counter-regulated genes have been clustered into functional categories and bioinformatic analysis has identified the B-Raf/Mek/Erk branch of the MAP kinase pathway as one containing several genes whose upregulation by TPA is blocked by ATRA. We also show that ATRA blocks signaling through this pathway, as revealed by immunohistochemistry and Western blotting. Finally, we found that blocking the B-Raf/Mek/Erk pathway with a pharmacological inhibitor, Sorafenib (BAY43-9006), induces squamous differentiation of existing skin SCCs formed in the 2-stage model.These results indicate that ATRA targets the B-Raf/Mek/Erk signaling pathway in the 2-stage mouse skin carcinogenesis model and this activity coincides with its chemopreventive action. This demonstrates the potential for targeting the B-Raf/Mek/Erk pathway for chemoprevention and therapy of skin SCC in humans. In addition our DNA microarray results provide the first expression signature for the chemopreventive effect of ATRA in a mouse skin cancer model. This is a potential source for novel targets for ATRA and other chemopreventive and therapeutic agents that can eventually be tested in the clinic." @default.
• W2111911402 created "2016-06-24" @default.
• W2111911402 creator A5010152548 @default.
• W2111911402 creator A5012786977 @default.
• W2111911402 creator A5022430976 @default.
• W2111911402 creator A5022780402 @default.
• W2111911402 creator A5024963249 @default.
• W2111911402 creator A5036516049 @default.
• W2111911402 creator A5041321734 @default.
• W2111911402 creator A5074741565 @default.
• W2111911402 creator A5077494651 @default.
• W2111911402 creator A5082133160 @default.
• W2111911402 creator A5089612099 @default.
• W2111911402 date "2009-05-11" @default.
• W2111911402 modified "2023-10-14" @default.
• W2111911402 title "Identification of the B-Raf/Mek/Erk MAP kinase pathway as a target for all-trans retinoic acid during skin cancer promotion" @default.
• W2111911402 cites W1927684145 @default.
• W2111911402 cites W1964201687 @default.
• W2111911402 cites W1965734230 @default.
• W2111911402 cites W1968824144 @default.
• W2111911402 cites W1970156673 @default.
• W2111911402 cites W1977281718 @default.
• W2111911402 cites W1981923906 @default.
• W2111911402 cites W1982466749 @default.
• W2111911402 cites W1992216304 @default.
• W2111911402 cites W1994331461 @default.
• W2111911402 cites W1998699021 @default.
• W2111911402 cites W2006805259 @default.
• W2111911402 cites W2009992069 @default.
• W2111911402 cites W2024902613 @default.
• W2111911402 cites W2029462907 @default.
• W2111911402 cites W2039249065 @default.
• W2111911402 cites W2040101943 @default.
• W2111911402 cites W2050082845 @default.
• W2111911402 cites W2058451329 @default.
• W2111911402 cites W2062289724 @default.
• W2111911402 cites W2070394850 @default.
• W2111911402 cites W2071388852 @default.
• W2111911402 cites W2072319964 @default.
• W2111911402 cites W2073070741 @default.
• W2111911402 cites W2075121435 @default.
• W2111911402 cites W2086403021 @default.
• W2111911402 cites W2087287360 @default.
• W2111911402 cites W2110795525 @default.
• W2111911402 cites W2112205129 @default.
• W2111911402 cites W2122172764 @default.
• W2111911402 cites W2131617162 @default.
• W2111911402 cites W2131989143 @default.
• W2111911402 cites W2140765540 @default.
• W2111911402 cites W2140827423 @default.
• W2111911402 cites W2143241514 @default.
• W2111911402 cites W2161710239 @default.
• W2111911402 cites W2312256607 @default.
• W2111911402 cites W2318366640 @default.
• W2111911402 cites W4244120818 @default.
• W2111911402 cites W4251201415 @default.
• W2111911402 doi "https://doi.org/10.1186/1476-4598-8-27" @default.
• W2111911402 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2685120" @default.
• W2111911402 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19432991" @default.
• W2111911402 hasPublicationYear "2009" @default.
• W2111911402 type Work @default.
• W2111911402 sameAs 2111911402 @default.
• W2111911402 citedByCount "45" @default.
• W2111911402 countsByYear W21119114022012 @default.
• W2111911402 countsByYear W21119114022013 @default.
• W2111911402 countsByYear W21119114022014 @default.
• W2111911402 countsByYear W21119114022015 @default.
• W2111911402 countsByYear W21119114022016 @default.
• W2111911402 countsByYear W21119114022018 @default.
• W2111911402 countsByYear W21119114022019 @default.
• W2111911402 countsByYear W21119114022020 @default.
• W2111911402 countsByYear W21119114022021 @default.
• W2111911402 countsByYear W21119114022022 @default.
• W2111911402 countsByYear W21119114022023 @default.
• W2111911402 crossrefType "journal-article" @default.
• W2111911402 hasAuthorship W2111911402A5010152548 @default.
• W2111911402 hasAuthorship W2111911402A5012786977 @default.
• W2111911402 hasAuthorship W2111911402A5022430976 @default.
• W2111911402 hasAuthorship W2111911402A5022780402 @default.
• W2111911402 hasAuthorship W2111911402A5024963249 @default.
• W2111911402 hasAuthorship W2111911402A5036516049 @default.
• W2111911402 hasAuthorship W2111911402A5041321734 @default.
• W2111911402 hasAuthorship W2111911402A5074741565 @default.
• W2111911402 hasAuthorship W2111911402A5077494651 @default.
• W2111911402 hasAuthorship W2111911402A5082133160 @default.
• W2111911402 hasAuthorship W2111911402A5089612099 @default.
• W2111911402 hasBestOaLocation W21119114021 @default.
• W2111911402 hasConcept C104317684 @default.
• W2111911402 hasConcept C121608353 @default.
• W2111911402 hasConcept C184235292 @default.
• W2111911402 hasConcept C2775954498 @default.
• W2111911402 hasConcept C2777789703 @default.
• W2111911402 hasConcept C2778938436 @default.
• W2111911402 hasConcept C2779963572 @default.
• W2111911402 hasConcept C2780122803 @default.
• W2111911402 hasConcept C2781121885 @default.
• W2111911402 hasConcept C2781249067 @default.
• W2111911402 hasConcept C502942594 @default.
• W2111911402 hasConcept C54355233 @default.
• W2111911402 hasConcept C55493867 @default.

• next