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- W2111916392 abstract "Dendritic spines have been proposed as primary sites of synaptic plasticity in the brain. Consistent with this hypothesis, spines contain high concentrations of actin, suggesting that they might be motile. To investigate this possibility, we made video recordings from hippocampal neurons expressing actin tagged with green fluorescent protein (GFP–actin). This reagent incorporates into actin-containing structures and allows the visualization of actin dynamics in living neurons. In mature neurons, recordings of GFP fluorescence revealed large actin-dependent changes in dendritic spine shape, similar to those inferred from previous studies using fixed tissues. Visible changes occured within seconds, suggesting that anatomical plasticity at synapses can be extremely rapid. As well as providing a molecular basis for structural plasticity, the presence of motile actin in dendritic spines implicates the postsynaptic element as a primary site of this phenomenon." @default.
- W2111916392 created "2016-06-24" @default.
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- W2111916392 date "1998-05-01" @default.
- W2111916392 modified "2023-10-11" @default.
- W2111916392 title "Rapid Actin-Based Plasticity in Dendritic Spines" @default.
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- W2111916392 doi "https://doi.org/10.1016/s0896-6273(00)80467-5" @default.
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