FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111921058> ?p ?o ?g. }

• W2111921058 endingPage "580" @default.
• W2111921058 startingPage "571" @default.
• W2111921058 abstract "The use of recently introduced biologics targeting specific immune mechanisms has identified crucial steps in the pathogenesis of psoriasis. Studying the dynamics of changes of these target mechanisms in sequential skin biopsies during treatment with biologics may reveal potential biomarkers. Correlation between clinical parameters and the expression of specific genes during treatments may identify markers indicative of treatment response. This observational open‐label study aimed to provide an overview of important cell biological changes in lesional skin during treatment with adalimumab, and their relationship to clinical improvement. Ten patients with moderate‐to‐severe plaque psoriasis were included and treated with adalimumab for 16 weeks. At baseline, and after 10 days and 16 weeks of treatment clinical scores were assessed and biopsies were taken to examine gene expression at the mRNA and protein level. The expression of marker genes for innate immunity, and epidermal differentiation and proliferation was rapidly restored to normal levels, whereas genes of the adaptive immune system showed a delayed decrease. The static and dynamic course of CD1a+ Langerhans cells and Ki67+ nuclei showed a significant strong correlation to the Psoriasis Area and Severity Index score. No correlation between interleukin‐17 expression and clinical scores was found. The innate immune system is affected during adalimumab treatment well before the changes in the adaptive immune system become apparent. We may speculate that the addition of a treatment with an early effect on adaptive immunity to adalimumab may result in superior effectiveness compared with monotherapies." @default.
• W2111921058 created "2016-06-24" @default.
• W2111921058 creator A5004571835 @default.
• W2111921058 creator A5005187273 @default.
• W2111921058 creator A5031523314 @default.
• W2111921058 creator A5040590679 @default.
• W2111921058 creator A5059022065 @default.
• W2111921058 creator A5064403166 @default.
• W2111921058 creator A5074436986 @default.
• W2111921058 creator A5075317406 @default.
• W2111921058 creator A5082636128 @default.
• W2111921058 creator A5084731166 @default.
• W2111921058 date "2014-03-01" @default.
• W2111921058 modified "2023-10-02" @default.
• W2111921058 title "The effect of adalimumab on key drivers in the pathogenesis of psoriasis" @default.
• W2111921058 cites W1594962297 @default.
• W2111921058 cites W1606040164 @default.
• W2111921058 cites W1607933978 @default.
• W2111921058 cites W1902683402 @default.
• W2111921058 cites W1969629598 @default.
• W2111921058 cites W1979209255 @default.
• W2111921058 cites W1982580853 @default.
• W2111921058 cites W2015166934 @default.
• W2111921058 cites W2016934329 @default.
• W2111921058 cites W2048365668 @default.
• W2111921058 cites W2049701162 @default.
• W2111921058 cites W2066723587 @default.
• W2111921058 cites W2075066605 @default.
• W2111921058 cites W2091442391 @default.
• W2111921058 cites W2092374642 @default.
• W2111921058 cites W2096620879 @default.
• W2111921058 cites W2103847895 @default.
• W2111921058 cites W2107277218 @default.
• W2111921058 cites W2113009253 @default.
• W2111921058 cites W2121126920 @default.
• W2111921058 cites W2138061716 @default.
• W2111921058 cites W2164203717 @default.
• W2111921058 cites W2404643853 @default.
• W2111921058 cites W262162 @default.
• W2111921058 cites W2885719909 @default.
• W2111921058 cites W4251839213 @default.
• W2111921058 doi "https://doi.org/10.1111/bjd.12705" @default.
• W2111921058 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24640989" @default.
• W2111921058 hasPublicationYear "2014" @default.
• W2111921058 type Work @default.
• W2111921058 sameAs 2111921058 @default.
• W2111921058 citedByCount "18" @default.
• W2111921058 countsByYear W21119210582014 @default.
• W2111921058 countsByYear W21119210582015 @default.
• W2111921058 countsByYear W21119210582016 @default.
• W2111921058 countsByYear W21119210582017 @default.
• W2111921058 countsByYear W21119210582018 @default.
• W2111921058 countsByYear W21119210582019 @default.
• W2111921058 countsByYear W21119210582020 @default.
• W2111921058 countsByYear W21119210582021 @default.
• W2111921058 countsByYear W21119210582023 @default.
• W2111921058 crossrefType "journal-article" @default.
• W2111921058 hasAuthorship W2111921058A5004571835 @default.
• W2111921058 hasAuthorship W2111921058A5005187273 @default.
• W2111921058 hasAuthorship W2111921058A5031523314 @default.
• W2111921058 hasAuthorship W2111921058A5040590679 @default.
• W2111921058 hasAuthorship W2111921058A5059022065 @default.
• W2111921058 hasAuthorship W2111921058A5064403166 @default.
• W2111921058 hasAuthorship W2111921058A5074436986 @default.
• W2111921058 hasAuthorship W2111921058A5075317406 @default.
• W2111921058 hasAuthorship W2111921058A5082636128 @default.
• W2111921058 hasAuthorship W2111921058A5084731166 @default.
• W2111921058 hasBestOaLocation W21119210581 @default.
• W2111921058 hasConcept C117220453 @default.
• W2111921058 hasConcept C126322002 @default.
• W2111921058 hasConcept C136449434 @default.
• W2111921058 hasConcept C17991360 @default.
• W2111921058 hasConcept C193419808 @default.
• W2111921058 hasConcept C203014093 @default.
• W2111921058 hasConcept C2524010 @default.
• W2111921058 hasConcept C2777011040 @default.
• W2111921058 hasConcept C2779341262 @default.
• W2111921058 hasConcept C2780132546 @default.
• W2111921058 hasConcept C2780564577 @default.
• W2111921058 hasConcept C2780942790 @default.
• W2111921058 hasConcept C33923547 @default.
• W2111921058 hasConcept C71924100 @default.
• W2111921058 hasConcept C8891405 @default.
• W2111921058 hasConceptScore W2111921058C117220453 @default.
• W2111921058 hasConceptScore W2111921058C126322002 @default.
• W2111921058 hasConceptScore W2111921058C136449434 @default.
• W2111921058 hasConceptScore W2111921058C17991360 @default.
• W2111921058 hasConceptScore W2111921058C193419808 @default.
• W2111921058 hasConceptScore W2111921058C203014093 @default.
• W2111921058 hasConceptScore W2111921058C2524010 @default.
• W2111921058 hasConceptScore W2111921058C2777011040 @default.
• W2111921058 hasConceptScore W2111921058C2779341262 @default.
• W2111921058 hasConceptScore W2111921058C2780132546 @default.
• W2111921058 hasConceptScore W2111921058C2780564577 @default.
• W2111921058 hasConceptScore W2111921058C2780942790 @default.
• W2111921058 hasConceptScore W2111921058C33923547 @default.
• W2111921058 hasConceptScore W2111921058C71924100 @default.
• W2111921058 hasConceptScore W2111921058C8891405 @default.

• next