FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111931699> ?p ?o ?g. }

• W2111931699 endingPage "631" @default.
• W2111931699 startingPage "623" @default.
• W2111931699 abstract "Platycodin-D (PD) is an effective triterpene saponin extracted from the root of Platycodon grandiflorum which has been used clinically to treat pulmonary diseases in traditional Chinese medicine. Recently, it has been reported that PD has anti-tumor effects in various cancer models through the induction of apoptosis. However, whether PD induces autophagy in both cell lines and its molecular mechanisms have not been elucidated. Here, our present study confirmed that PD induced autophagy in both NCI-H460 and A549 cells via up-regulating the expression levels of Atg-3, Atg-7 and Beclin-1. Meanwhile, PD contributed to the up-regulation of LC3-II at both protein and mRNA levels. Further detection of the PI3K/Akt/mTOR signaling pathway compared to LY294002 (PI3K kinase inhibitor), RAP (mTOR kinase inhibitor) and insulin (an activator of PI3K/Akt/mTOR signaling pathway) showed that PD induced autophagy through inhibiting the pathway at p-Akt (Ser473), p-p70S6K (Thr389) and p-4EBP1 (Thr37/46) in both cell lines. Moreover, the examination of MAPK signaling pathway showed that PD treatment increased the phosphorylation of JNK and p38 MAPK, while decreased the phosphorylation of Erk1/2 in both cell lines. Additionally, the effects assessed with a panel of pharmacologic inhibitors, including U0126 (Erk1/2 kinase inhibitor), SP600125 (JNK kinase inhibitor) and SB203580 (p38 MAPK kinase inhibitor) suggested that the activation of JNK and p38 MAPK participated in PD-induced autophagy. Taken together, these findings suggested that PD induced autophagy in NCI-H460 and A549 cells through inhibiting PI3K/Akt/mTOR signaling pathway and activating JNK and p38 MAPK signaling pathways. Therefore, PD may be an alternative compound for NSCLC therapy." @default.
• W2111931699 created "2016-06-24" @default.
• W2111931699 creator A5008691388 @default.
• W2111931699 creator A5029314547 @default.
• W2111931699 creator A5033784640 @default.
• W2111931699 creator A5036486877 @default.
• W2111931699 creator A5065779734 @default.
• W2111931699 creator A5072454821 @default.
• W2111931699 creator A5075317021 @default.
• W2111931699 creator A5077002195 @default.
• W2111931699 date "2015-01-01" @default.
• W2111931699 modified "2023-10-18" @default.
• W2111931699 title "Platycodin-D Induced Autophagy in Non-Small Cell Lung Cancer Cells via PI3K/Akt/mTOR and MAPK Signaling Pathways" @default.
• W2111931699 cites W1521411817 @default.
• W2111931699 cites W1523693806 @default.
• W2111931699 cites W1529396499 @default.
• W2111931699 cites W1966662013 @default.
• W2111931699 cites W1972133970 @default.
• W2111931699 cites W1988212011 @default.
• W2111931699 cites W1990037409 @default.
• W2111931699 cites W1991125047 @default.
• W2111931699 cites W1994823455 @default.
• W2111931699 cites W1998152698 @default.
• W2111931699 cites W2000302322 @default.
• W2111931699 cites W2004131942 @default.
• W2111931699 cites W2008156964 @default.
• W2111931699 cites W2036317083 @default.
• W2111931699 cites W2055248710 @default.
• W2111931699 cites W2057274775 @default.
• W2111931699 cites W2063033676 @default.
• W2111931699 cites W2068041606 @default.
• W2111931699 cites W2068153705 @default.
• W2111931699 cites W2082853003 @default.
• W2111931699 cites W2083911670 @default.
• W2111931699 cites W2084946596 @default.
• W2111931699 cites W2087136249 @default.
• W2111931699 cites W2109827751 @default.
• W2111931699 cites W2115890535 @default.
• W2111931699 cites W2117952220 @default.
• W2111931699 cites W2126783165 @default.
• W2111931699 cites W2142845200 @default.
• W2111931699 cites W2150168624 @default.
• W2111931699 cites W2164778558 @default.
• W2111931699 doi "https://doi.org/10.7150/jca.11291" @default.
• W2111931699 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4466411" @default.
• W2111931699 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26078792" @default.
• W2111931699 hasPublicationYear "2015" @default.
• W2111931699 type Work @default.
• W2111931699 sameAs 2111931699 @default.
• W2111931699 citedByCount "96" @default.
• W2111931699 countsByYear W21119316992015 @default.
• W2111931699 countsByYear W21119316992016 @default.
• W2111931699 countsByYear W21119316992017 @default.
• W2111931699 countsByYear W21119316992018 @default.
• W2111931699 countsByYear W21119316992019 @default.
• W2111931699 countsByYear W21119316992020 @default.
• W2111931699 countsByYear W21119316992021 @default.
• W2111931699 countsByYear W21119316992022 @default.
• W2111931699 countsByYear W21119316992023 @default.
• W2111931699 crossrefType "journal-article" @default.
• W2111931699 hasAuthorship W2111931699A5008691388 @default.
• W2111931699 hasAuthorship W2111931699A5029314547 @default.
• W2111931699 hasAuthorship W2111931699A5033784640 @default.
• W2111931699 hasAuthorship W2111931699A5036486877 @default.
• W2111931699 hasAuthorship W2111931699A5065779734 @default.
• W2111931699 hasAuthorship W2111931699A5072454821 @default.
• W2111931699 hasAuthorship W2111931699A5075317021 @default.
• W2111931699 hasAuthorship W2111931699A5077002195 @default.
• W2111931699 hasBestOaLocation W21119316991 @default.
• W2111931699 hasConcept C184235292 @default.
• W2111931699 hasConcept C185592680 @default.
• W2111931699 hasConcept C190283241 @default.
• W2111931699 hasConcept C203522944 @default.
• W2111931699 hasConcept C2776912716 @default.
• W2111931699 hasConcept C43060935 @default.
• W2111931699 hasConcept C502942594 @default.
• W2111931699 hasConcept C51551487 @default.
• W2111931699 hasConcept C55493867 @default.
• W2111931699 hasConcept C57074206 @default.
• W2111931699 hasConcept C62478195 @default.
• W2111931699 hasConcept C75217442 @default.
• W2111931699 hasConcept C81729549 @default.
• W2111931699 hasConcept C86554907 @default.
• W2111931699 hasConcept C86803240 @default.
• W2111931699 hasConcept C95444343 @default.
• W2111931699 hasConcept C98490376 @default.
• W2111931699 hasConceptScore W2111931699C184235292 @default.
• W2111931699 hasConceptScore W2111931699C185592680 @default.
• W2111931699 hasConceptScore W2111931699C190283241 @default.
• W2111931699 hasConceptScore W2111931699C203522944 @default.
• W2111931699 hasConceptScore W2111931699C2776912716 @default.
• W2111931699 hasConceptScore W2111931699C43060935 @default.
• W2111931699 hasConceptScore W2111931699C502942594 @default.
• W2111931699 hasConceptScore W2111931699C51551487 @default.
• W2111931699 hasConceptScore W2111931699C55493867 @default.
• W2111931699 hasConceptScore W2111931699C57074206 @default.
• W2111931699 hasConceptScore W2111931699C62478195 @default.
• W2111931699 hasConceptScore W2111931699C75217442 @default.

• next