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• W2111942021 abstract "▪ Abstract The lung is a complex organ consisting of numerous cell types that function to ensure sufficient gas exchange to oxygenate the blood. In order to accomplish this function, the lung must be exposed to the external environment and at the same time maintain a homeostatic balance between its function in gas exchange and the maintenance of inflammatory balance. During the past two decades, as molecular methodologies have evolved with the sequencing of entire genomes, the use of in vivo models to elucidate the molecular mechanisms involved in pulmonary physiology and disease have increased. The mouse has emerged as a potent model to investigate pulmonary physiology due to the explosion in molecular methods that now allow for the developmental and tissue-specific regulation of gene transcription. Initial efforts to manipulate gene expression in the mouse genome resulted in the generation of transgenic mice characterized by the constitutive expression of a specific gene and knockout mice characterized ..." @default.
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• W2111942021 date "2005-03-01" @default.
• W2111942021 modified "2023-10-16" @default.
• W2111942021 title "Genetically engineered mouse models for lung cancer" @default.
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• W2111942021 doi "https://doi.org/10.1016/j.ddmod.2005.05.020" @default.
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