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• W2111944900 abstract "Cytogenetic analysis of a primary germ-cell tumor originating from the streak gonad of a 20-year-old phenotypic female with a 46,XY karyotype and mixed gonadal dysgenesis revealed a 48,XY, +7, +i(12p) chromosomal pattern. Germ-cell tumors originating from gonads of normal males are usually highly aneuploid. An isochromosome 12p as well as an overrepresentation of chromosome 7 material are among the specific changes most consistently observed. The present case shows that tumors of dysgenetic gonads, albeit being near-diploid, may exhibit similar chromosomal changes. This observation lends additional support to the hypothesis that these specific cytogenetic anomalies may play an important role in the pathogenesis of human germ-cell tumors." @default.
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• W2111944900 date "1991-12-01" @default.
• W2111944900 modified "2023-09-27" @default.
• W2111944900 title "A 46,XY female with mixed gonadal dysgenesis and a 48,XY,+7,+i(12p) chromosome pattern in a primary gonadal tumor" @default.
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• W2111944900 doi "https://doi.org/10.1016/0165-4608(91)90155-n" @default.
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