FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111946145> ?p ?o ?g. }

• W2111946145 abstract "Ductal carcinoma in situ (DCIS) of the breast includes a heterogeneous group of preinvasive tumors with uncertain evolution. Definition of the molecular factors necessary for progression to invasive disease is crucial to determining which lesions are likely to become invasive. To obtain insight into the molecular basis of DCIS, we compared the gene expression pattern of cells from the following samples: non-neoplastic, pure DCIS, in situ component of lesions with co-existing invasive ductal carcinoma, and invasive ductal carcinoma. Forty-one samples were evaluated: four non-neoplastic, five pure DCIS, 22 in situ component of lesions with co-existing invasive ductal carcinoma, and 10 invasive ductal carcinoma. Pure cell populations were isolated using laser microdissection. Total RNA was purified, DNase treated, and amplified using the T7-based method. Microarray analysis was conducted using a customized cDNA platform. The concept of molecular divergence was applied to classify the sample groups using analysis of variance followed by Tukey's test. Among the tumor sample groups, cells from pure DCIS exhibited the most divergent molecular profile, consequently identifying cells from in situ component of lesions with co-existing invasive ductal carcinoma as very similar to cells from invasive lesions. Additionally, we identified 147 genes that were differentially expressed between pure DCIS and in situ component of lesions with co-existing invasive ductal carcinoma, which can discriminate samples representative of in situ component of lesions with co-existing invasive ductal carcinoma from 60% of pure DCIS samples. A gene subset was evaluated using quantitative RT-PCR, which confirmed differential expression for 62.5% and 60.0% of them using initial and partial independent sample groups, respectively. Among these genes, LOX and SULF-1 exhibited features that identify them as potential participants in the malignant process of DCIS. We identified new genes that are potentially involved in the malignant transformation of DCIS, and our findings strongly suggest that cells from the in situ component of lesions with co-existing invasive ductal carcinoma exhibit molecular alterations that enable them to invade the surrounding tissue before morphological changes in the lesion become apparent." @default.
• W2111946145 created "2016-06-24" @default.
• W2111946145 creator A5018468033 @default.
• W2111946145 creator A5026777870 @default.
• W2111946145 creator A5027227089 @default.
• W2111946145 creator A5043984351 @default.
• W2111946145 creator A5051933272 @default.
• W2111946145 creator A5060723951 @default.
• W2111946145 creator A5076356518 @default.
• W2111946145 creator A5084997825 @default.
• W2111946145 date "2008-10-01" @default.
• W2111946145 modified "2023-10-09" @default.
• W2111946145 title "Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma" @default.
• W2111946145 cites W1520956379 @default.
• W2111946145 cites W1591103902 @default.
• W2111946145 cites W183095101 @default.
• W2111946145 cites W1898087812 @default.
• W2111946145 cites W1951386398 @default.
• W2111946145 cites W1964311653 @default.
• W2111946145 cites W1970586717 @default.
• W2111946145 cites W1986612073 @default.
• W2111946145 cites W1999463736 @default.
• W2111946145 cites W2012573463 @default.
• W2111946145 cites W2015577765 @default.
• W2111946145 cites W2017046939 @default.
• W2111946145 cites W2020973917 @default.
• W2111946145 cites W2031583495 @default.
• W2111946145 cites W2033363278 @default.
• W2111946145 cites W2035401398 @default.
• W2111946145 cites W2044702943 @default.
• W2111946145 cites W2052986647 @default.
• W2111946145 cites W2053300345 @default.
• W2111946145 cites W2053953532 @default.
• W2111946145 cites W2056930379 @default.
• W2111946145 cites W2068007920 @default.
• W2111946145 cites W2078325464 @default.
• W2111946145 cites W2093921289 @default.
• W2111946145 cites W2097195427 @default.
• W2111946145 cites W2097255042 @default.
• W2111946145 cites W2097785208 @default.
• W2111946145 cites W2098827180 @default.
• W2111946145 cites W2100668965 @default.
• W2111946145 cites W2102778060 @default.
• W2111946145 cites W2103543394 @default.
• W2111946145 cites W2105224356 @default.
• W2111946145 cites W2105381419 @default.
• W2111946145 cites W2105457070 @default.
• W2111946145 cites W2106314624 @default.
• W2111946145 cites W2108244474 @default.
• W2111946145 cites W2110279965 @default.
• W2111946145 cites W2116764617 @default.
• W2111946145 cites W2119603925 @default.
• W2111946145 cites W2120991664 @default.
• W2111946145 cites W2128985829 @default.
• W2111946145 cites W2129164843 @default.
• W2111946145 cites W2132484381 @default.
• W2111946145 cites W2149660955 @default.
• W2111946145 cites W2163074585 @default.
• W2111946145 cites W2219032770 @default.
• W2111946145 cites W2259802687 @default.
• W2111946145 cites W45534775 @default.
• W2111946145 doi "https://doi.org/10.1186/bcr2157" @default.
• W2111946145 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2614523" @default.
• W2111946145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18928525" @default.
• W2111946145 hasPublicationYear "2008" @default.
• W2111946145 type Work @default.
• W2111946145 sameAs 2111946145 @default.
• W2111946145 citedByCount "124" @default.
• W2111946145 countsByYear W21119461452012 @default.
• W2111946145 countsByYear W21119461452013 @default.
• W2111946145 countsByYear W21119461452014 @default.
• W2111946145 countsByYear W21119461452015 @default.
• W2111946145 countsByYear W21119461452016 @default.
• W2111946145 countsByYear W21119461452017 @default.
• W2111946145 countsByYear W21119461452018 @default.
• W2111946145 countsByYear W21119461452019 @default.
• W2111946145 countsByYear W21119461452020 @default.
• W2111946145 countsByYear W21119461452021 @default.
• W2111946145 countsByYear W21119461452022 @default.
• W2111946145 countsByYear W21119461452023 @default.
• W2111946145 crossrefType "journal-article" @default.
• W2111946145 hasAuthorship W2111946145A5018468033 @default.
• W2111946145 hasAuthorship W2111946145A5026777870 @default.
• W2111946145 hasAuthorship W2111946145A5027227089 @default.
• W2111946145 hasAuthorship W2111946145A5043984351 @default.
• W2111946145 hasAuthorship W2111946145A5051933272 @default.
• W2111946145 hasAuthorship W2111946145A5060723951 @default.
• W2111946145 hasAuthorship W2111946145A5076356518 @default.
• W2111946145 hasAuthorship W2111946145A5084997825 @default.
• W2111946145 hasBestOaLocation W21119461451 @default.
• W2111946145 hasConcept C104317684 @default.
• W2111946145 hasConcept C11242284 @default.
• W2111946145 hasConcept C121608353 @default.
• W2111946145 hasConcept C125965507 @default.
• W2111946145 hasConcept C142724271 @default.
• W2111946145 hasConcept C150194340 @default.
• W2111946145 hasConcept C178790620 @default.
• W2111946145 hasConcept C185592680 @default.
• W2111946145 hasConcept C204232928 @default.
• W2111946145 hasConcept C2777546739 @default.

• next