FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111958293> ?p ?o ?g. }

• W2111958293 endingPage "4404" @default.
• W2111958293 startingPage "4398" @default.
• W2111958293 abstract "Flap endonuclease 1 (FEN1) and Dna2 endonuclease/helicase (Dna2) sequentially coordinate their nuclease activities for efficient resolution of flap structures that are created during the maturation of Okazaki fragments and repair of DNA damage. Acetylation of FEN1 by p300 inhibits its endonuclease activity, impairing flap cleavage, a seemingly undesirable effect. We now show that p300 also acetylates Dna2, stimulating its 5'-3' endonuclease, the 5'-3' helicase, and DNA-dependent ATPase activities. Furthermore, acetylated Dna2 binds its DNA substrates with higher affinity. Differential regulation of the activities of the two endonucleases by p300 indicates a mechanism in which the acetylase promotes formation of longer flaps in the cell at the same time as ensuring correct processing. Intentional formation of longer flaps mediated by p300 in an active chromatin environment would increase the resynthesis patch size, providing increased opportunity for incorrect nucleotide removal during DNA replication and damaged nucleotide removal during DNA repair. For example, altering the ratio between short and long flap Okazaki fragment processing would be a mechanism for better correction of the error-prone synthesis catalyzed by DNA polymerase alpha." @default.
• W2111958293 created "2016-06-24" @default.
• W2111958293 creator A5000378293 @default.
• W2111958293 creator A5005315226 @default.
• W2111958293 creator A5021657789 @default.
• W2111958293 creator A5044595207 @default.
• W2111958293 creator A5071924748 @default.
• W2111958293 date "2010-02-01" @default.
• W2111958293 modified "2023-10-11" @default.
• W2111958293 title "Acetylation of Dna2 Endonuclease/Helicase and Flap Endonuclease 1 by p300 Promotes DNA Stability by Creating Long Flap Intermediates" @default.
• W2111958293 cites W1516609571 @default.
• W2111958293 cites W1974573561 @default.
• W2111958293 cites W1976634184 @default.
• W2111958293 cites W1977047204 @default.
• W2111958293 cites W1988914928 @default.
• W2111958293 cites W1997002747 @default.
• W2111958293 cites W2008233500 @default.
• W2111958293 cites W2009024472 @default.
• W2111958293 cites W2014720884 @default.
• W2111958293 cites W2018284593 @default.
• W2111958293 cites W2020258031 @default.
• W2111958293 cites W2039114116 @default.
• W2111958293 cites W2046152711 @default.
• W2111958293 cites W2053213954 @default.
• W2111958293 cites W2054615119 @default.
• W2111958293 cites W2054877486 @default.
• W2111958293 cites W2059464918 @default.
• W2111958293 cites W2062043277 @default.
• W2111958293 cites W2084825928 @default.
• W2111958293 cites W2088032208 @default.
• W2111958293 cites W2095079660 @default.
• W2111958293 cites W2096549833 @default.
• W2111958293 cites W2107856790 @default.
• W2111958293 cites W2111202021 @default.
• W2111958293 cites W2117947454 @default.
• W2111958293 cites W2138569524 @default.
• W2111958293 cites W2139795906 @default.
• W2111958293 cites W2153314555 @default.
• W2111958293 cites W2161248815 @default.
• W2111958293 cites W2165336005 @default.
• W2111958293 cites W2171763930 @default.
• W2111958293 doi "https://doi.org/10.1074/jbc.m109.086397" @default.
• W2111958293 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2836044" @default.
• W2111958293 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20019387" @default.
• W2111958293 hasPublicationYear "2010" @default.
• W2111958293 type Work @default.
• W2111958293 sameAs 2111958293 @default.
• W2111958293 citedByCount "59" @default.
• W2111958293 countsByYear W21119582932012 @default.
• W2111958293 countsByYear W21119582932013 @default.
• W2111958293 countsByYear W21119582932014 @default.
• W2111958293 countsByYear W21119582932015 @default.
• W2111958293 countsByYear W21119582932016 @default.
• W2111958293 countsByYear W21119582932017 @default.
• W2111958293 countsByYear W21119582932018 @default.
• W2111958293 countsByYear W21119582932019 @default.
• W2111958293 countsByYear W21119582932020 @default.
• W2111958293 countsByYear W21119582932021 @default.
• W2111958293 countsByYear W21119582932022 @default.
• W2111958293 countsByYear W21119582932023 @default.
• W2111958293 crossrefType "journal-article" @default.
• W2111958293 hasAuthorship W2111958293A5000378293 @default.
• W2111958293 hasAuthorship W2111958293A5005315226 @default.
• W2111958293 hasAuthorship W2111958293A5021657789 @default.
• W2111958293 hasAuthorship W2111958293A5044595207 @default.
• W2111958293 hasAuthorship W2111958293A5071924748 @default.
• W2111958293 hasBestOaLocation W21119582931 @default.
• W2111958293 hasConcept C104317684 @default.
• W2111958293 hasConcept C11305352 @default.
• W2111958293 hasConcept C134935766 @default.
• W2111958293 hasConcept C153911025 @default.
• W2111958293 hasConcept C161223559 @default.
• W2111958293 hasConcept C185592680 @default.
• W2111958293 hasConcept C2756471 @default.
• W2111958293 hasConcept C2777028655 @default.
• W2111958293 hasConcept C2777271071 @default.
• W2111958293 hasConcept C552990157 @default.
• W2111958293 hasConcept C55493867 @default.
• W2111958293 hasConcept C67705224 @default.
• W2111958293 hasConcept C73573662 @default.
• W2111958293 hasConcept C83640560 @default.
• W2111958293 hasConcept C86803240 @default.
• W2111958293 hasConcept C95444343 @default.
• W2111958293 hasConcept C98086919 @default.
• W2111958293 hasConceptScore W2111958293C104317684 @default.
• W2111958293 hasConceptScore W2111958293C11305352 @default.
• W2111958293 hasConceptScore W2111958293C134935766 @default.
• W2111958293 hasConceptScore W2111958293C153911025 @default.
• W2111958293 hasConceptScore W2111958293C161223559 @default.
• W2111958293 hasConceptScore W2111958293C185592680 @default.
• W2111958293 hasConceptScore W2111958293C2756471 @default.
• W2111958293 hasConceptScore W2111958293C2777028655 @default.
• W2111958293 hasConceptScore W2111958293C2777271071 @default.
• W2111958293 hasConceptScore W2111958293C552990157 @default.
• W2111958293 hasConceptScore W2111958293C55493867 @default.
• W2111958293 hasConceptScore W2111958293C67705224 @default.
• W2111958293 hasConceptScore W2111958293C73573662 @default.
• W2111958293 hasConceptScore W2111958293C83640560 @default.

• next