FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2111995654> ?p ?o ?g. }

• W2111995654 endingPage "1681" @default.
• W2111995654 startingPage "1666" @default.
• W2111995654 abstract "Deletion of copper-zinc superoxide dismutase (CuZnSOD) in Sod1–/– mice leads to accelerated loss of muscle mass and force during aging, but the losses do not occur with muscle-specific deletion of CuZnSOD. To determine the role of motor neurons in the muscle decline, we generated transgenic Sod1–/– mice in which CuZnSOD was expressed under control of the synapsin 1 promoter (SynTgSod1–/– mice). SynTgSod1–/– mice expressed CuZnSOD in brain, spinal cord, and peripheral nerve, but not in other tissues. Sciatic nerve CuZnSOD content in SynTgSod1–/– mice was ~20% that of control mice, but no reduction in muscle mass or isometric force was observed in SynTg-Sod1–/– mice compared with control animals, whereas muscles of age-matched Sod1–/– mice displayed 30–40% reductions in mass and force. In addition, increased oxidative damage and adaptations in stress responses observed in muscles of Sod1–/– mice were absent in SynTgSod1–/– mice, and degeneration of neuromuscular junction (NMJ) structure and function occurred in Sod1–/– mice but not in SynTgSod1–/– mice. Our data demonstrate that specific CuZnSOD expression in neurons is sufficient to preserve NMJ and skeletal muscle structure and function in Sod1–/– mice and suggest that redox homeostasis in motor neurons plays a key role in initiating sarcopenia during aging.—Sakellariou, G. K., Davis, C. S., Shi, Y., Ivannikov, M. V., Zhang, Y., Vasilaki, A., Macleod, G. T., Richardson, A., Van Remmen, H., Jackson, M. J., McArdle, A., Brooks, S. V. Neuron-specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD-knockout mice. FASEB J. 28, 1666-1681 (2014). www.fasebj.org" @default.
• W2111995654 created "2016-06-24" @default.
• W2111995654 creator A5000765673 @default.
• W2111995654 creator A5014647586 @default.
• W2111995654 creator A5033771107 @default.
• W2111995654 creator A5041063837 @default.
• W2111995654 creator A5043233902 @default.
• W2111995654 creator A5050725093 @default.
• W2111995654 creator A5054346772 @default.
• W2111995654 creator A5061020688 @default.
• W2111995654 creator A5067840753 @default.
• W2111995654 creator A5071424209 @default.
• W2111995654 creator A5071824081 @default.
• W2111995654 creator A5080559983 @default.
• W2111995654 date "2013-12-30" @default.
• W2111995654 modified "2023-09-24" @default.
• W2111995654 title "Neuron‐specific expression of CuZnSOD prevents the loss of muscle mass and function that occurs in homozygous CuZnSOD‐knockout mice" @default.
• W2111995654 cites W1494360569 @default.
• W2111995654 cites W1496181943 @default.
• W2111995654 cites W1502614187 @default.
• W2111995654 cites W1575773325 @default.
• W2111995654 cites W1978742311 @default.
• W2111995654 cites W1990119562 @default.
• W2111995654 cites W1992384426 @default.
• W2111995654 cites W2016475350 @default.
• W2111995654 cites W2031053537 @default.
• W2111995654 cites W2037295316 @default.
• W2111995654 cites W2039213813 @default.
• W2111995654 cites W2040751146 @default.
• W2111995654 cites W2042637324 @default.
• W2111995654 cites W2047232246 @default.
• W2111995654 cites W2049797752 @default.
• W2111995654 cites W2056791346 @default.
• W2111995654 cites W2075566081 @default.
• W2111995654 cites W2080046990 @default.
• W2111995654 cites W2082798387 @default.
• W2111995654 cites W2087431155 @default.
• W2111995654 cites W2099375619 @default.
• W2111995654 cites W2101983583 @default.
• W2111995654 cites W2103415764 @default.
• W2111995654 cites W2104007452 @default.
• W2111995654 cites W2108318541 @default.
• W2111995654 cites W2119627241 @default.
• W2111995654 cites W2119691405 @default.
• W2111995654 cites W2122087230 @default.
• W2111995654 cites W2133312408 @default.
• W2111995654 cites W2137182040 @default.
• W2111995654 cites W2137423625 @default.
• W2111995654 cites W2149142681 @default.
• W2111995654 cites W2152962449 @default.
• W2111995654 cites W2154394704 @default.
• W2111995654 cites W2156315357 @default.
• W2111995654 doi "https://doi.org/10.1096/fj.13-240390" @default.
• W2111995654 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3963022" @default.
• W2111995654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24378874" @default.
• W2111995654 hasPublicationYear "2013" @default.
• W2111995654 type Work @default.
• W2111995654 sameAs 2111995654 @default.
• W2111995654 citedByCount "72" @default.
• W2111995654 countsByYear W21119956542014 @default.
• W2111995654 countsByYear W21119956542015 @default.
• W2111995654 countsByYear W21119956542016 @default.
• W2111995654 countsByYear W21119956542017 @default.
• W2111995654 countsByYear W21119956542018 @default.
• W2111995654 countsByYear W21119956542019 @default.
• W2111995654 countsByYear W21119956542020 @default.
• W2111995654 countsByYear W21119956542021 @default.
• W2111995654 countsByYear W21119956542022 @default.
• W2111995654 countsByYear W21119956542023 @default.
• W2111995654 crossrefType "journal-article" @default.
• W2111995654 hasAuthorship W2111995654A5000765673 @default.
• W2111995654 hasAuthorship W2111995654A5014647586 @default.
• W2111995654 hasAuthorship W2111995654A5033771107 @default.
• W2111995654 hasAuthorship W2111995654A5041063837 @default.
• W2111995654 hasAuthorship W2111995654A5043233902 @default.
• W2111995654 hasAuthorship W2111995654A5050725093 @default.
• W2111995654 hasAuthorship W2111995654A5054346772 @default.
• W2111995654 hasAuthorship W2111995654A5061020688 @default.
• W2111995654 hasAuthorship W2111995654A5067840753 @default.
• W2111995654 hasAuthorship W2111995654A5071424209 @default.
• W2111995654 hasAuthorship W2111995654A5071824081 @default.
• W2111995654 hasAuthorship W2111995654A5080559983 @default.
• W2111995654 hasBestOaLocation W21119956542 @default.
• W2111995654 hasConcept C102230213 @default.
• W2111995654 hasConcept C104317684 @default.
• W2111995654 hasConcept C126322002 @default.
• W2111995654 hasConcept C130316041 @default.
• W2111995654 hasConcept C134018914 @default.
• W2111995654 hasConcept C148785051 @default.
• W2111995654 hasConcept C169760540 @default.
• W2111995654 hasConcept C170493617 @default.
• W2111995654 hasConcept C182704531 @default.
• W2111995654 hasConcept C185592680 @default.
• W2111995654 hasConcept C2775838275 @default.
• W2111995654 hasConcept C2776151105 @default.
• W2111995654 hasConcept C2776214593 @default.
• W2111995654 hasConcept C2776263037 @default.
• W2111995654 hasConcept C2776752467 @default.

• next