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• W2112021685 abstract "The rapid global spread of multi-resistant bacteria and loss of antibiotic effectiveness increases the risk of initial inappropriate antibiotic therapy (IAT) and poses a serious threat to patient safety. We conducted a systematic review and meta-analysis of published studies to summarize the effect of appropriate antibiotic therapy (AAT) or IAT against gram-negative bacterial infections in the hospital setting. MEDLINE, EMBASE, and Cochrane CENTRAL databases were searched until May 2014 to identify English-language studies examining use of AAT or IAT in hospitalized patients with Gram-negative pathogens. Outcomes of interest included mortality, clinical cure, cost, and length of stay. Citations and eligible full-text articles were screened in duplicate. Random effect models meta-analysis was used. Fifty-seven studies in 60 publications were eligible. AAT was associated with lower risk of mortality (unadjusted summary odds ratio [OR] 0.38, 95 % confidence interval [CI] 0.30-0.47, 39 studies, 5809 patients) and treatment failure (OR 0.22, 95 % CI 0.14–0.35; 3 studies, 283 patients). Conversely, IAT increased risk of mortality (unadjusted summary OR 2.66, 95 % CI 2.12–3.35; 39 studies, 5809 patients). In meta-analyses of adjusted data, AAT was associated with lower risk of mortality (adjusted summary OR 0.43, 95 % CI 0.23–0.83; 6 studies, 1409 patients). Conversely, IAT increased risk of mortality (adjusted summary OR 3.30, 95 % CI 2.42–4.49; 16 studies, 2493 patients). A limited number of studies suggested higher cost and longer hospital stay with IAT. There was considerable heterogeneity in the definition of AAT or IAT, pathogens studied, and outcomes assessed. Using a large set of studies we found that IAT is associated with a number of serious consequences,including an increased risk of hospital mortality. Infections caused by drug-resistant, Gram-negative organisms represent a considerable financial burden to healthcare systems due to the increased costs associated with the resources required to manage the infection, particularly longer hospital stays. However, there were insufficient data that evaluated AAT for the outcome of costs among patients with nosocomialGram-negative infections. IAT in hospitalized patients with Gram-negative infections is associated with adverse outcomes. Technological advances for rapid diagnostics to facilitate AAT along with antimicrobial stewardship, surveillance, infection control, and prevention is needed." @default.
• W2112021685 created "2016-06-24" @default.
• W2112021685 creator A5022078990 @default.
• W2112021685 creator A5060812761 @default.
• W2112021685 creator A5062282892 @default.
• W2112021685 creator A5062900128 @default.
• W2112021685 date "2015-09-30" @default.
• W2112021685 modified "2023-10-11" @default.
• W2112021685 title "Appropriate initial antibiotic therapy in hospitalized patients with gram-negative infections: systematic review and meta-analysis" @default.
• W2112021685 cites W105772679 @default.
• W2112021685 cites W117346746 @default.
• W2112021685 cites W1503852907 @default.
• W2112021685 cites W1548936307 @default.
• W2112021685 cites W1553366182 @default.
• W2112021685 cites W1951903794 @default.
• W2112021685 cites W1956837549 @default.
• W2112021685 cites W1971808723 @default.
• W2112021685 cites W1980567277 @default.
• W2112021685 cites W1982600413 @default.
• W2112021685 cites W1986795560 @default.
• W2112021685 cites W1990436230 @default.
• W2112021685 cites W1997678673 @default.
• W2112021685 cites W1998375265 @default.
• W2112021685 cites W2001095294 @default.
• W2112021685 cites W2007872832 @default.
• W2112021685 cites W2009574631 @default.
• W2112021685 cites W2018083848 @default.
• W2112021685 cites W2022087921 @default.
• W2112021685 cites W2023302805 @default.
• W2112021685 cites W2024880400 @default.
• W2112021685 cites W2027025614 @default.
• W2112021685 cites W2030501295 @default.
• W2112021685 cites W2036798623 @default.
• W2112021685 cites W2040425453 @default.
• W2112021685 cites W2041005541 @default.
• W2112021685 cites W2044577704 @default.
• W2112021685 cites W2048928537 @default.
• W2112021685 cites W2054807444 @default.
• W2112021685 cites W2055696179 @default.
• W2112021685 cites W2058364008 @default.
• W2112021685 cites W2061979273 @default.
• W2112021685 cites W2062724622 @default.
• W2112021685 cites W2064031612 @default.
• W2112021685 cites W2066490569 @default.
• W2112021685 cites W2069684250 @default.
• W2112021685 cites W2074669461 @default.
• W2112021685 cites W2078064161 @default.
• W2112021685 cites W2085755428 @default.
• W2112021685 cites W2086445439 @default.
• W2112021685 cites W2087865186 @default.
• W2112021685 cites W2093638471 @default.
• W2112021685 cites W2096253545 @default.
• W2112021685 cites W2098310975 @default.
• W2112021685 cites W2102123421 @default.
• W2112021685 cites W2103077615 @default.
• W2112021685 cites W2103121782 @default.
• W2112021685 cites W2103360123 @default.
• W2112021685 cites W2107328434 @default.
• W2112021685 cites W2107810227 @default.
• W2112021685 cites W2108638835 @default.
• W2112021685 cites W2109412254 @default.
• W2112021685 cites W2117200377 @default.
• W2112021685 cites W2118975078 @default.
• W2112021685 cites W2123184982 @default.
• W2112021685 cites W2124791748 @default.
• W2112021685 cites W2128956519 @default.
• W2112021685 cites W2129003269 @default.
• W2112021685 cites W2139456867 @default.
• W2112021685 cites W2141637785 @default.
• W2112021685 cites W2144929147 @default.
• W2112021685 cites W2148442300 @default.
• W2112021685 cites W2150326412 @default.
• W2112021685 cites W2150458023 @default.
• W2112021685 cites W2153868993 @default.
• W2112021685 cites W2157823046 @default.
• W2112021685 cites W2163100965 @default.
• W2112021685 cites W2163992070 @default.
• W2112021685 cites W2164697816 @default.
• W2112021685 cites W2166198738 @default.
• W2112021685 cites W2167757532 @default.
• W2112021685 cites W2188181987 @default.
• W2112021685 cites W4230543984 @default.
• W2112021685 cites W4249635827 @default.
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• W2112021685 doi "https://doi.org/10.1186/s12879-015-1123-5" @default.
• W2112021685 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4589179" @default.
• W2112021685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26423743" @default.
• W2112021685 hasPublicationYear "2015" @default.
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