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- W2112033786 abstract "Abstract In an attempt to search for more potent positive inotropic agents, a series of 2‐(4‐(4‐substituted benzyloxy)‐3‐methoxybenzyl)‐1,4‐diazepan‐1‐yl)‐ N ‐(4,5‐dihydro‐1‐methyl[1,2,4]triazolo[4,3‐ a ]quinolin‐7‐yl)acetamides was synthesized and their positive inotropic activities were evaluated by measuring left atrium stroke volume on isolated rabbit‐heart preparations. Several compounds showed favorable activity compared with the standard drug Milrinone among which 2‐(4‐(4‐(2‐chlorobenzyloxy)‐3‐methoxybenzyl)‐1,4‐diazepan‐1‐yl)‐ N ‐(4,5‐dihydro‐1‐methyl‐[1,2,4]triazolo[4,3‐ a ]quinolin‐7‐yl)acetamide 6e was found to have the most desirable potency with the 6.79 ± 0.18% increased stroke volume (Milrinone: 1.67 ± 0.64%) at a concentration of 1×10 –5 M in our in‐vitro study. The chronotropic effects of those compounds having inotropic effects were also evaluated in this work." @default.
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- W2112033786 date "2008-11-21" @default.
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- W2112033786 title "Synthesis and Positive Inotropic Evaluation of 2-(4-(4-Substituted benzyloxy)-3-methoxybenzyl)-1,4-diazepan-1-yl)-<i>N</i>-(4,5-dihydro-1-methyl[1,2,4]triazolo[4,3-<i>a</i>]quinolin-7-yl)-acetamides" @default.
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- W2112033786 doi "https://doi.org/10.1002/ardp.200800132" @default.
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