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• W2112043527 abstract "Previously, we reported the cloning of α4 type V collagen, a novel member of the collagen type V gene family that is expressed by Schwann cells in developing peripheral nerves (Chernousov et al., 2000). The present study was performed to investigate the effects of this collagen on the adhesion and migration of premyelinating Schwann cells and neurite outgrowth from embryonic dorsal root ganglion neurons. Purified α4(V)-containing collagen isolated from Schwann cell conditioned medium (collagen type V_SC) promoted migration of Schwann cells but inhibited outgrowth of axons from rat embryo dorsal root ganglia. Collagen type V_SC blocked axonal outgrowth in the presence of otherwise active substrates such as collagen type IV, indicative of active inhibition. The noncollagen N-terminal domain of α4(V) promoted Schwann cell adhesion, spreading, and migration. These processes were inhibited by soluble heparin but not by function-blocking antibodies against α1- and α2-integrins. The collagen domain of pepsin-digested collagen type V was poorly adhesive for Schwann cells. The type V collagen domain but not the α4(V) N-terminal domain blocked neurite outgrowth from dorsal root ganglion neurons. In cocultures of dorsal root ganglion neurons and Schwann cells, collagen type V_SC promoted axon fasciculation and association of axons with Schwann cells. These results suggest that in embryonic peripheral nerves, collagen type V_SC plays a dual role in regulating cell migration. This represents a heretofore unrecognized function of peripheral nerve collagen fibrils in regulating patterns of peripheral nerve growth during development." @default.
• W2112043527 created "2016-06-24" @default.
• W2112043527 creator A5032415588 @default.
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• W2112043527 date "2001-08-15" @default.
• W2112043527 modified "2023-10-12" @default.
• W2112043527 title "Schwann Cell Type V Collagen Inhibits Axonal Outgrowth and Promotes Schwann Cell Migration via Distinct Adhesive Activities of the Collagen and Noncollagen Domains" @default.
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• W2112043527 doi "https://doi.org/10.1523/jneurosci.21-16-06125.2001" @default.
• W2112043527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6763180" @default.
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