FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112044013> ?p ?o ?g. }

• W2112044013 endingPage "829" @default.
• W2112044013 startingPage "820" @default.
• W2112044013 abstract "Essential to tissue-engineered vascular grafts is the formation of a functional endothelial monolayer capable of resisting the forces of blood flow. This study targeted alpha2(VIII) collagen, a major component of the subendothelial matrix, and examined the ability of and mechanisms by which endothelial cells attach to this collagen under static and dynamic conditions both in vitro and in vivo.Attachment of human endothelial cells to recombinant alpha2(VIII) collagen was assessed in vitro under static and shear conditions of up to 100 dyne/cm2. Alpha2(VIII) collagen supported endothelial cell attachment in a dose-dependent manner, with an 18-fold higher affinity for endothelial cells compared with fibronectin. Cell attachment was significantly inhibited by function-blocking anti-alpha2 (56%) and -beta1 (98%) integrin antibodies but was not RGD dependent. Under flow, endothelial cells were retained at significantly higher levels on alpha2(VIII) collagen (53% and 51%) than either fibronectin (23% and 16%) or glass substrata (7% and 1%) at shear rates of 30 and 60 dyne/cm2, respectively. In vivo studies, using endothelialized polyurethane grafts, demonstrated significantly higher cell retention rates to alpha2(VIII) collagen-coated than to fibronectin-coated prostheses in the midgraft area (P < 0.05) after 24 hours' implantation in the caprine carotid artery.These studies demonstrate that alpha2(VIII) collagen has the potential to improve both initial cell attachment and retention of endothelial cells on vascular grafts in vivo, which opens new avenues of research into the development of single-stage endothelialized prostheses and the next generation of tissue-engineered vascular grafts." @default.
• W2112044013 created "2016-06-24" @default.
• W2112044013 creator A5000246031 @default.
• W2112044013 creator A5001854589 @default.
• W2112044013 creator A5026474084 @default.
• W2112044013 creator A5028934350 @default.
• W2112044013 creator A5038831914 @default.
• W2112044013 creator A5052276045 @default.
• W2112044013 creator A5071497079 @default.
• W2112044013 creator A5087400385 @default.
• W2112044013 date "2006-08-22" @default.
• W2112044013 modified "2023-09-27" @default.
• W2112044013 title "α ₂ (VIII) Collagen Substrata Enhance Endothelial Cell Retention Under Acute Shear Stress Flow via an α ₂ β ₁ Integrin–Dependent Mechanism" @default.
• W2112044013 cites W1559514166 @default.
• W2112044013 cites W1569377852 @default.
• W2112044013 cites W1579822466 @default.
• W2112044013 cites W1698189665 @default.
• W2112044013 cites W172461958 @default.
• W2112044013 cites W1963643264 @default.
• W2112044013 cites W1972249640 @default.
• W2112044013 cites W1975208950 @default.
• W2112044013 cites W1977169440 @default.
• W2112044013 cites W1983269054 @default.
• W2112044013 cites W1986584864 @default.
• W2112044013 cites W1996114718 @default.
• W2112044013 cites W1998155328 @default.
• W2112044013 cites W2004007203 @default.
• W2112044013 cites W2019032424 @default.
• W2112044013 cites W2026356178 @default.
• W2112044013 cites W2035593678 @default.
• W2112044013 cites W2046968705 @default.
• W2112044013 cites W2049498788 @default.
• W2112044013 cites W2053001031 @default.
• W2112044013 cites W2064855567 @default.
• W2112044013 cites W2065347722 @default.
• W2112044013 cites W2083682299 @default.
• W2112044013 cites W2085795560 @default.
• W2112044013 cites W2087832723 @default.
• W2112044013 cites W2105695271 @default.
• W2112044013 cites W2120022739 @default.
• W2112044013 cites W2123475866 @default.
• W2112044013 cites W2124600270 @default.
• W2112044013 cites W2132175455 @default.
• W2112044013 cites W2155187315 @default.
• W2112044013 cites W2157603347 @default.
• W2112044013 cites W2163791375 @default.
• W2112044013 cites W2172144171 @default.
• W2112044013 cites W2408991791 @default.
• W2112044013 doi "https://doi.org/10.1161/circulationaha.106.635292" @default.
• W2112044013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16908762" @default.
• W2112044013 hasPublicationYear "2006" @default.
• W2112044013 type Work @default.
• W2112044013 sameAs 2112044013 @default.
• W2112044013 citedByCount "28" @default.
• W2112044013 countsByYear W21120440132012 @default.
• W2112044013 countsByYear W21120440132013 @default.
• W2112044013 countsByYear W21120440132014 @default.
• W2112044013 countsByYear W21120440132015 @default.
• W2112044013 countsByYear W21120440132017 @default.
• W2112044013 countsByYear W21120440132019 @default.
• W2112044013 countsByYear W21120440132020 @default.
• W2112044013 countsByYear W21120440132021 @default.
• W2112044013 countsByYear W21120440132022 @default.
• W2112044013 countsByYear W21120440132023 @default.
• W2112044013 crossrefType "journal-article" @default.
• W2112044013 hasAuthorship W2112044013A5000246031 @default.
• W2112044013 hasAuthorship W2112044013A5001854589 @default.
• W2112044013 hasAuthorship W2112044013A5026474084 @default.
• W2112044013 hasAuthorship W2112044013A5028934350 @default.
• W2112044013 hasAuthorship W2112044013A5038831914 @default.
• W2112044013 hasAuthorship W2112044013A5052276045 @default.
• W2112044013 hasAuthorship W2112044013A5071497079 @default.
• W2112044013 hasAuthorship W2112044013A5087400385 @default.
• W2112044013 hasBestOaLocation W21120440131 @default.
• W2112044013 hasConcept C123012128 @default.
• W2112044013 hasConcept C12554922 @default.
• W2112044013 hasConcept C126322002 @default.
• W2112044013 hasConcept C142724271 @default.
• W2112044013 hasConcept C1491633281 @default.
• W2112044013 hasConcept C150903083 @default.
• W2112044013 hasConcept C153911025 @default.
• W2112044013 hasConcept C159985019 @default.
• W2112044013 hasConcept C185592680 @default.
• W2112044013 hasConcept C189165786 @default.
• W2112044013 hasConcept C192562407 @default.
• W2112044013 hasConcept C195687474 @default.
• W2112044013 hasConcept C202751555 @default.
• W2112044013 hasConcept C203014093 @default.
• W2112044013 hasConcept C207001950 @default.
• W2112044013 hasConcept C21141959 @default.
• W2112044013 hasConcept C2776992346 @default.
• W2112044013 hasConcept C2780644872 @default.
• W2112044013 hasConcept C55493867 @default.
• W2112044013 hasConcept C71924100 @default.
• W2112044013 hasConcept C86492073 @default.
• W2112044013 hasConcept C86803240 @default.
• W2112044013 hasConcept C95444343 @default.
• W2112044013 hasConceptScore W2112044013C123012128 @default.

• next