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• W2112051710 abstract "Type II diabetes and obesity are major health problems worldwide and aboriginal peoples are particularly at risk. To address this problem in Canadian native populations for whom modern pharmaceuticals are culturally misadapted, our team is testing the traditional pharmacopeia of the James Bay Cree for anti-diabetic and anti-obesity activities. More specifically, the aim of the present study was to define the effects of traditional plants on intestinal glucose absorption, an under-appreciated antihyperglycaemic and anti-obesity activity. Crude ethanol extracts of seventeen Boreal forest medicinal plants were examined in the Caco-2 human enterocytic cell line and compared to the competitive classical inhibitors phlorizin and phloretin. It is worth noting that the latter compounds are polyphenols that share many structural characteristics with components of several Cree plants. Thirteen of seventeen extracts were observed to significantly inhibit uptake when administered simultaneously with 3H-deoxyglucose. Inhibition was dose-dependent and, in a few cases, even surpassed that induced by a combination of the positive controls. To validate these effects in-vivo, four plant extracts were administered by intragastric gavage at 250 mg/kg to normal rats simultaneously with a 3 g/kg bolus of glucose. This resulted in a decrease in peak glycaemia by approximately 40% for two of them. These findings indicate that competitive inhibition of facilitative intestinal glucose uptake can be achieved by crude extracts of medicinal plants. Intake of the latter with meals may help control postprandial glycaemia and reduce caloric intake in high risk populations." @default.
• W2112051710 created "2016-06-24" @default.
• W2112051710 creator A5022082218 @default.
• W2112051710 date "2010-05-05" @default.
• W2112051710 modified "2023-09-27" @default.
• W2112051710 title "Inhibition de l'absorption intestinale du glucose par les produits naturels issus de la pharmacopée traditionnelle des Cris de la Baie James" @default.
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