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• W2112061176 abstract "Objective: To determine the impact of perioperative β-adrenergic receptor (βAR) antagonist administration on neurologic complications. Design: Observational database analysis. Setting: A clinical investigation at a single tertiary academic medical center. Participants: Elective coronary artery bypass graft surgical patients operated on in the period 1994-1996. Interventions: Patients were divided into 2 groups: (1) patients given βAR antagonist–blocking drugs in the perioperative period, including during operation, and (2) patients not given βAR antagonists. Measurements and Main Results: βAR antagonist use in 2,575 consecutive patients undergoing coronary artery bypass graft surgery (1994-1996) was determined using the Cardiovascular Database and Anesthesia Information System Database. Outcome variables were postoperative stroke, coma, and transient ischemic attack. Of patients, 113 (4.4%) had postoperative neurologic complications, including stroke (n = 44), coma (n = 12), and transient ischemic attack (n = 3). Of patients, 2,296 (89%) received perioperative βAR antagonist therapy, and 279 (11%) did not. Adverse neurologic events occurred in 3.9% (n = 90) of patients who received perioperative βAR antagonists and 8.2% (n = 23) of patients who did not receive βAR antagonists (odds ratio, 0.45; 95% confidence interval, 0.28 to 0.73; p = 0.003, unadjusted.) Severe neurologic outcomes (stroke and coma) occurred in 1.9% (n = 44) of patients who received βAR antagonists and 4.3% (n = 12) of patients who did not receive βAR antagonists (odds ratio, 0.43; 95% confidence interval, 0.23 to 0.83; p = 0.016). Conclusion: Use of β-adrenergic antagonists was associated with a substantial reduction in the incidence of postoperative neurologic complications. A prospective randomized trial is needed to verify this potentially important neuroprotective strategy in cardiac surgery. Copyright 2002, Elsevier Science (USA). All rights reserved." @default.
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• W2112061176 date "2002-06-01" @default.
• W2112061176 modified "2023-10-13" @default.
• W2112061176 title "Neuroprotection is associated with β-adrenergic receptor antagonists during cardiac surgery: Evidence from 2,575 patients" @default.
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• W2112061176 doi "https://doi.org/10.1053/jcan.2002.124132" @default.
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