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• W2112071061 abstract "Abstract Evidence suggests that genome chromatinization and the posttranslational modification of histones are involved in the regulation of viral gene expression, including the human cytomegalovirus (HCMV). We performed a ChIP-on-Chip assay to determine whether histone deacetylases (HDACs) interact with HCMV genomic DNA on a global level. Surprisingly, we found that HDAC3, but not HDAC2, interacts not only with the major immediate early (MIE) promoter but also with the entire MIE locus, suggesting a heterogeneous interaction of HDAC3 with HCMV DNA. The interaction of HDAC3 with the MIE region is related to inhibition of viral replication because HDAC3 inhibitors enhanced HCMV replication." @default.
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• W2112071061 date "2011-03-31" @default.
• W2112071061 modified "2023-09-27" @default.
• W2112071061 title "Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus" @default.
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• W2112071061 doi "https://doi.org/10.1186/1743-422x-8-151" @default.
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