FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112084234> ?p ?o ?g. }

• W2112084234 endingPage "4694" @default.
• W2112084234 startingPage "4684" @default.
• W2112084234 abstract "We have previously reported that insulin and osmotic shock stimulate an increase in glucose transport activity and translocation of the insulin-responsive glucose transporter isoform GLUT4 to the plasma membrane through distinct pathways in 3T3L1 adipocytes (D. Chen, J. S. Elmendorf, A. L. Olson, X. Li, H. S. Earp, and J. E. Pessin, J. Biol. Chem. 272:27401–27410, 1997). In investigations of the relationships between these two signaling pathways, we have now observed that these two stimuli are not additive, and, in fact, osmotic shock pretreatment was found to completely prevent any further insulin stimulation of glucose transport activity and GLUT4 protein translocation. In addition, osmotic shock inhibited the insulin stimulation of lipogenesis and glycogen synthesis. This inhibition of insulin-stimulated downstream signaling occurred without any significant effect on insulin receptor autophosphorylation or tyrosine phosphorylation of insulin receptor substrate 1 (IRS1). Furthermore, there was no effect on either the insulin-stimulated association of the p85 type I phosphatidylinositol (PI) 3-kinase regulatory subunit with IRS1 or phosphotyrosine antibody-immunoprecipitated PI 3-kinase activity. In contrast, osmotic shock pretreatment markedly inhibited the insulin stimulation of protein kinase B (PKB) and p70S6 kinase activities. In addition, the dephosphorylation of PKB was prevented by pretreatment with the phosphatase inhibitors okadaic acid and calyculin A. These data support a model in which osmotic shock-induced insulin resistance of downstream biological responses results from an inhibition of insulin-stimulated PKB activation." @default.
• W2112084234 created "2016-06-24" @default.
• W2112084234 creator A5001330715 @default.
• W2112084234 creator A5017016608 @default.
• W2112084234 creator A5061199927 @default.
• W2112084234 creator A5067998513 @default.
• W2112084234 creator A5077728712 @default.
• W2112084234 date "1999-07-01" @default.
• W2112084234 modified "2023-10-11" @default.
• W2112084234 title "Osmotic Shock Inhibits Insulin Signaling by Maintaining Akt/Protein Kinase B in an Inactive Dephosphorylated State" @default.
• W2112084234 cites W1481070153 @default.
• W2112084234 cites W1525701947 @default.
• W2112084234 cites W1572009433 @default.
• W2112084234 cites W1602425018 @default.
• W2112084234 cites W1726025741 @default.
• W2112084234 cites W1753097959 @default.
• W2112084234 cites W1770003392 @default.
• W2112084234 cites W1841050729 @default.
• W2112084234 cites W1912098244 @default.
• W2112084234 cites W1955121353 @default.
• W2112084234 cites W1969345044 @default.
• W2112084234 cites W1970529208 @default.
• W2112084234 cites W1970548320 @default.
• W2112084234 cites W1972307668 @default.
• W2112084234 cites W1973372369 @default.
• W2112084234 cites W1973837499 @default.
• W2112084234 cites W1977795081 @default.
• W2112084234 cites W1978781152 @default.
• W2112084234 cites W1981053590 @default.
• W2112084234 cites W1987105275 @default.
• W2112084234 cites W1989294105 @default.
• W2112084234 cites W1999163644 @default.
• W2112084234 cites W2002054992 @default.
• W2112084234 cites W2004078164 @default.
• W2112084234 cites W2016135608 @default.
• W2112084234 cites W2017481487 @default.
• W2112084234 cites W2018917333 @default.
• W2112084234 cites W2018926746 @default.
• W2112084234 cites W2031504013 @default.
• W2112084234 cites W2035414423 @default.
• W2112084234 cites W2042925168 @default.
• W2112084234 cites W2044868069 @default.
• W2112084234 cites W2046933787 @default.
• W2112084234 cites W2058138221 @default.
• W2112084234 cites W2059424055 @default.
• W2112084234 cites W2064801081 @default.
• W2112084234 cites W2071686558 @default.
• W2112084234 cites W2073586734 @default.
• W2112084234 cites W2075326322 @default.
• W2112084234 cites W2094068658 @default.
• W2112084234 cites W2100040836 @default.
• W2112084234 cites W2109223015 @default.
• W2112084234 cites W2112009693 @default.
• W2112084234 cites W2117483382 @default.
• W2112084234 cites W2120742142 @default.
• W2112084234 cites W2143947670 @default.
• W2112084234 cites W2146157811 @default.
• W2112084234 cites W2146854995 @default.
• W2112084234 cites W2146989813 @default.
• W2112084234 cites W2147207624 @default.
• W2112084234 cites W2150032835 @default.
• W2112084234 cites W2152931086 @default.
• W2112084234 cites W2154713680 @default.
• W2112084234 cites W2165604272 @default.
• W2112084234 cites W2165982157 @default.
• W2112084234 cites W2169825848 @default.
• W2112084234 cites W2413152052 @default.
• W2112084234 cites W89084389 @default.
• W2112084234 cites W91266548 @default.
• W2112084234 doi "https://doi.org/10.1128/mcb.19.7.4684" @default.
• W2112084234 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/84266" @default.
• W2112084234 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10373517" @default.
• W2112084234 hasPublicationYear "1999" @default.
• W2112084234 type Work @default.
• W2112084234 sameAs 2112084234 @default.
• W2112084234 citedByCount "104" @default.
• W2112084234 countsByYear W21120842342012 @default.
• W2112084234 countsByYear W21120842342014 @default.
• W2112084234 countsByYear W21120842342015 @default.
• W2112084234 countsByYear W21120842342016 @default.
• W2112084234 countsByYear W21120842342017 @default.
• W2112084234 countsByYear W21120842342018 @default.
• W2112084234 countsByYear W21120842342021 @default.
• W2112084234 crossrefType "journal-article" @default.
• W2112084234 hasAuthorship W2112084234A5001330715 @default.
• W2112084234 hasAuthorship W2112084234A5017016608 @default.
• W2112084234 hasAuthorship W2112084234A5061199927 @default.
• W2112084234 hasAuthorship W2112084234A5067998513 @default.
• W2112084234 hasAuthorship W2112084234A5077728712 @default.
• W2112084234 hasBestOaLocation W21120842341 @default.
• W2112084234 hasConcept C112446052 @default.
• W2112084234 hasConcept C11960822 @default.
• W2112084234 hasConcept C126322002 @default.
• W2112084234 hasConcept C134018914 @default.
• W2112084234 hasConcept C150109051 @default.
• W2112084234 hasConcept C161573976 @default.
• W2112084234 hasConcept C185967709 @default.
• W2112084234 hasConcept C197902417 @default.

• next