FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112135302> ?p ?o ?g. }

• W2112135302 endingPage "1280" @default.
• W2112135302 startingPage "1268" @default.
• W2112135302 abstract "Axonal injury is believed to be a major determinant of adverse outcomes following traumatic brain injury. However, it has been difficult to assess acutely the severity of axonal injury in human traumatic brain injury patients. We hypothesized that microdialysis-based measurements of the brain extracellular fluid levels of tau and neurofilament light chain, two low molecular weight axonal proteins, could be helpful in this regard. To test this hypothesis, 100 kDa cut-off microdialysis catheters were placed in 16 patients with severe traumatic brain injury at two neurological/neurosurgical intensive care units. Tau levels in the microdialysis samples were highest early and fell over time in all patients. Initial tau levels were >3-fold higher in patients with microdialysis catheters placed in pericontusional regions than in patients in whom catheters were placed in normal-appearing right frontal lobe tissue (P = 0.005). Tau levels and neurofilament light-chain levels were positively correlated (r = 0.6, P = 0.013). Neurofilament light-chain levels were also higher in patients with pericontusional catheters (P = 0.04). Interestingly, initial tau levels were inversely correlated with initial amyloid-β levels measured in the same samples (r = -0.87, P = 0.000023). This could be due to reduced synaptic activity in areas with substantial axonal injury, as amyloid-β release is closely coupled with synaptic activity. Importantly, high initial tau levels correlated with worse clinical outcomes, as assessed using the Glasgow Outcome Scale 6 months after injury (r = -0.6, P = 0.018). Taken together, our data add support for the hypothesis that axonal injury may be related to long-term impairments following traumatic brain injury. Microdialysis-based measurement of tau levels in the brain extracellular space may be a useful way to assess the severity of axonal injury acutely in the intensive care unit. Further studies with larger numbers of patients will be required to assess the reproducibility of these findings and to determine whether this approach provides added value when combined with clinical and radiological information." @default.
• W2112135302 created "2016-06-24" @default.
• W2112135302 creator A5013668952 @default.
• W2112135302 creator A5037473873 @default.
• W2112135302 creator A5038221757 @default.
• W2112135302 creator A5039264740 @default.
• W2112135302 creator A5046564023 @default.
• W2112135302 creator A5048603891 @default.
• W2112135302 creator A5061621727 @default.
• W2112135302 creator A5065549626 @default.
• W2112135302 creator A5088998527 @default.
• W2112135302 date "2011-11-23" @default.
• W2112135302 modified "2023-10-14" @default.
• W2112135302 title "Tau elevations in the brain extracellular space correlate with reduced amyloid-β levels and predict adverse clinical outcomes after severe traumatic brain injury" @default.
• W2112135302 cites W1490397100 @default.
• W2112135302 cites W1495292563 @default.
• W2112135302 cites W1544685573 @default.
• W2112135302 cites W1544972323 @default.
• W2112135302 cites W1573176358 @default.
• W2112135302 cites W1581789419 @default.
• W2112135302 cites W1603121691 @default.
• W2112135302 cites W1881753072 @default.
• W2112135302 cites W1951784167 @default.
• W2112135302 cites W1963923550 @default.
• W2112135302 cites W1964049915 @default.
• W2112135302 cites W1966483255 @default.
• W2112135302 cites W1970107990 @default.
• W2112135302 cites W1972491904 @default.
• W2112135302 cites W1977001142 @default.
• W2112135302 cites W1977416667 @default.
• W2112135302 cites W1977627126 @default.
• W2112135302 cites W1977687604 @default.
• W2112135302 cites W1978979736 @default.
• W2112135302 cites W1981630211 @default.
• W2112135302 cites W1982605872 @default.
• W2112135302 cites W1982772772 @default.
• W2112135302 cites W1989282675 @default.
• W2112135302 cites W1989719980 @default.
• W2112135302 cites W1995096028 @default.
• W2112135302 cites W1997874814 @default.
• W2112135302 cites W1998068768 @default.
• W2112135302 cites W2006521106 @default.
• W2112135302 cites W2010067869 @default.
• W2112135302 cites W2011949052 @default.
• W2112135302 cites W2012062176 @default.
• W2112135302 cites W2013333500 @default.
• W2112135302 cites W2018867075 @default.
• W2112135302 cites W2021177863 @default.
• W2112135302 cites W2022532556 @default.
• W2112135302 cites W2029934068 @default.
• W2112135302 cites W2030312267 @default.
• W2112135302 cites W2031375851 @default.
• W2112135302 cites W2037001126 @default.
• W2112135302 cites W2037488206 @default.
• W2112135302 cites W2040636124 @default.
• W2112135302 cites W2046556619 @default.
• W2112135302 cites W2046952010 @default.
• W2112135302 cites W2052019737 @default.
• W2112135302 cites W2058606598 @default.
• W2112135302 cites W2058859054 @default.
• W2112135302 cites W2060278375 @default.
• W2112135302 cites W2060286035 @default.
• W2112135302 cites W2060351135 @default.
• W2112135302 cites W2062809743 @default.
• W2112135302 cites W2063896948 @default.
• W2112135302 cites W2065205627 @default.
• W2112135302 cites W2065904280 @default.
• W2112135302 cites W2068330750 @default.
• W2112135302 cites W2068767931 @default.
• W2112135302 cites W2069544582 @default.
• W2112135302 cites W2078152043 @default.
• W2112135302 cites W2081325915 @default.
• W2112135302 cites W2083249651 @default.
• W2112135302 cites W2087381559 @default.
• W2112135302 cites W2091184929 @default.
• W2112135302 cites W2092703451 @default.
• W2112135302 cites W2096698246 @default.
• W2112135302 cites W2096859537 @default.
• W2112135302 cites W2099390250 @default.
• W2112135302 cites W2103982815 @default.
• W2112135302 cites W2108029018 @default.
• W2112135302 cites W2111394367 @default.
• W2112135302 cites W2124443688 @default.
• W2112135302 cites W2129285116 @default.
• W2112135302 cites W2133652987 @default.
• W2112135302 cites W2135515253 @default.
• W2112135302 cites W2136321913 @default.
• W2112135302 cites W2143812931 @default.
• W2112135302 cites W2154813265 @default.
• W2112135302 cites W2160699120 @default.
• W2112135302 cites W2167200799 @default.
• W2112135302 cites W2170424940 @default.
• W2112135302 cites W4249810852 @default.
• W2112135302 cites W2011984756 @default.
• W2112135302 cites W4230565756 @default.
• W2112135302 doi "https://doi.org/10.1093/brain/awr286" @default.
• W2112135302 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3326246" @default.
• W2112135302 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22116192" @default.

• next