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• W2112145713 abstract "Type IV pili are polymeric bacterial appendages that affect host cell interaction, motility, biofilm formation, and horizontal gene transfer. These force-generating motors work in at least three distinct velocity modes—elongation, and retraction at two distinct speeds, high and low. Yet it is unclear which regulatory inputs control their speeds. Here, we addressed this question for the human pathogen Neisseria gonorrhoeae. Using a combination of image analysis and surface analytics, we simultaneously monitored the speed of twitching motility and the concentration of oxygen. While oxygen was detectable, bacteria moved in the high-speed mode (1.5 μm/s). Upon full depletion of oxygen, gonococci simultaneously switched into the low-speed mode (0.5 μm/s). Speed switching was complete within seconds, independent of transcription, and reversible upon oxygen restoration. Using laser tweezers, we found that oxygen depletion triggered speed switching of the pilus motor at the single-molecule level. In the transition regime, single pili switched between both modes, indicating bistability. Switching is well described by a two-state model whereby the oxygen level controls the occupancy of the states." @default.
• W2112145713 created "2016-06-24" @default.
• W2112145713 creator A5021042058 @default.
• W2112145713 creator A5022345811 @default.
• W2112145713 date "2012-06-01" @default.
• W2112145713 modified "2023-10-03" @default.
• W2112145713 title "Oxygen Depletion Triggers Switching between Discrete Speed Modes of Gonococcal Type IV Pili" @default.
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• W2112145713 doi "https://doi.org/10.1016/j.bpj.2012.04.020" @default.
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