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- W2112156618 abstract "Conformational changes of Klebsiella aerogenes urease apoprotein (UreABC)3 induced upon binding of the UreD and UreF accessory proteins were examined by a combination of flexibility analysis, mutagenesis, and small-angle X-ray scattering (SAXS). ProFlex analysis of urease provided evidence that the major domain of UreB can move in a hinge-like motion to account for prior chemical cross-linking results. Rigidification of the UreB hinge region, accomplished through a G11P mutation, reduced the extent of urease activation, in part by decreasing the nickel content of the mutant enzyme, and by sequestering a portion of the urease apoprotein in a novel activation complex that includes all of the accessory proteins. SAXS analyses of urease, (UreABC–UreD)3, and (UreABC–UreDF)3 confirm that UreD and UreF bind near UreB at the periphery of the (UreAC)3 structure. This study supports an activation model in which a domain-shifted UreB conformation in (UreABC–UreDF)3 allows CO2 and nickel ions to gain access to the nascent active site." @default.
- W2112156618 created "2016-06-24" @default.
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- W2112156618 date "2008-12-01" @default.
- W2112156618 modified "2023-10-17" @default.
- W2112156618 title "The structure of urease activation complexes examined by flexibility analysis, mutagenesis, and small-angle X-ray scattering" @default.
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- W2112156618 doi "https://doi.org/10.1016/j.abb.2008.09.004" @default.
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