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• W2112156721 startingPage "9992" @default.
• W2112156721 abstract "Vpr is a small accessory protein of human and simian immunodeficiency viruses (HIV and SIV) that is specifically incorporated into virions. Members of the HIV-2/SIV(sm)/SIV(mac) lineage of primate lentiviruses also incorporate a related protein designated Vpx. We previously identified a highly conserved L-X-X-L-F sequence near the C terminus of the p6 domain of the Gag precursor as the major virion association motif for HIV-1 Vpr. In the present study, we show that a different leucine-containing motif (D-X-A-X-X-L-L) in the N-terminal half of p6(gag) is required for the incorporation of SIV(mac) Vpx. Similarly, the uptake of SIV(mac) Vpr depended primarily on the D-X-A-X-X-L-L motif. SIV(mac) Vpr was unstable when expressed alone, but its intracellular steady-state levels increased significantly in the presence of wild-type Gag or of the proteasome inhibitor lactacystin. Collectively, our results indicate that the interaction with the Gag precursor via the D-X-A-X-X-L-L motif diverts SIV(mac) Vpr away from the proteasome-degradative pathway. While absent from HIV-1 p6(gag), the D-X-A-X-X-L-L motif is conserved in both the HIV-2/SIV(sm)/SIV(mac) and SIV(agm) lineages of primate lentiviruses. We found that the incorporation of SIV(agm) Vpr, like that of SIV(mac) Vpx, is absolutely dependent on the D-X-A-X-X-L-L motif, while the L-X-X-L-F motif used by HIV-1 Vpr is dispensable. The similar requirements for the incorporation of SIV(mac) Vpx and SIV(agm) Vpr provide support for their proposed common ancestry." @default.
• W2112156721 created "2016-06-24" @default.
• W2112156721 creator A5021728410 @default.
• W2112156721 creator A5025320897 @default.
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• W2112156721 creator A5038843379 @default.
• W2112156721 date "1999-12-01" @default.
• W2112156721 modified "2023-10-14" @default.
• W2112156721 title "A Conserved Dileucine-Containing Motif in p6 ^<i>gag</i> Governs the Particle Association of Vpx and Vpr of Simian Immunodeficiency Viruses SIV _mac and SIV _agm" @default.
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• W2112156721 doi "https://doi.org/10.1128/jvi.73.12.9992-9999.1999" @default.
• W2112156721 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/113050" @default.
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• W2112156721 hasPublicationYear "1999" @default.
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