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- W2112168564 endingPage "1380" @default.
- W2112168564 startingPage "1365" @default.
- W2112168564 abstract "Introduction: Accumulating evidence attributes a significant role to aldose reductase (ALR2) in the pathogenesis of several inflammatory pathologies. Aldose reductase inhibitors (ARIs) were found to attenuate reactive oxygen species (ROS) production both in vitro and in vivo. Thus, they disrupt signaling cascades that lead to the production of cytokines/chemokines, which induce and exacerbate inflammation. As a result, ARIs might hold a significant therapeutic potential as alternate anti-inflammatory drugs. Areas covered: The authors present a comprehensive review of the current data that support the central role of ALR2 in several inflammatory pathologies (i.e., diabetes, cancer, sepsis, asthma and ocular inflammation). Further, the authors describe the potential underlying molecular mechanisms and provide a commentary on the status of ARIs in this field. Expert opinion: It is important that future efforts focus on delineating all the steps of the molecular mechanism that implicates ALR2 in inflammatory pathologies. At the same time, utilizing the previous efforts in the field of ARIs, several candidates that have been proven safe in the clinic may be evaluated for their clinical significance as anti-inflammatory medication. Finally, structurally novel ARIs, designed to target specifically the proinflammatory subpocket of ALR2, should be pursued." @default.
- W2112168564 created "2016-06-24" @default.
- W2112168564 creator A5026499401 @default.
- W2112168564 creator A5071897565 @default.
- W2112168564 creator A5072428548 @default.
- W2112168564 creator A5091842934 @default.
- W2112168564 date "2013-10-03" @default.
- W2112168564 modified "2023-10-14" @default.
- W2112168564 title "Development of aldose reductase inhibitors for the treatment of inflammatory disorders" @default.
- W2112168564 cites W1494867744 @default.
- W2112168564 cites W1570748607 @default.
- W2112168564 cites W1601924230 @default.
- W2112168564 cites W1605340054 @default.
- W2112168564 cites W1610033131 @default.
- W2112168564 cites W1968766344 @default.
- W2112168564 cites W1972852504 @default.
- W2112168564 cites W1973403564 @default.
- W2112168564 cites W1974033843 @default.
- W2112168564 cites W1975669691 @default.
- W2112168564 cites W1978540532 @default.
- W2112168564 cites W1979580000 @default.
- W2112168564 cites W1980979880 @default.
- W2112168564 cites W1986315358 @default.
- W2112168564 cites W1986604347 @default.
- W2112168564 cites W1986723384 @default.
- W2112168564 cites W1988244470 @default.
- W2112168564 cites W1988635561 @default.
- W2112168564 cites W1988945136 @default.
- W2112168564 cites W1989786909 @default.
- W2112168564 cites W1992245975 @default.
- W2112168564 cites W1996213262 @default.
- W2112168564 cites W2002709542 @default.
- W2112168564 cites W2003184318 @default.
- W2112168564 cites W2003655395 @default.
- W2112168564 cites W2003954103 @default.
- W2112168564 cites W2005379932 @default.
- W2112168564 cites W2010868896 @default.
- W2112168564 cites W2016004451 @default.
- W2112168564 cites W2016946930 @default.
- W2112168564 cites W2018828431 @default.
- W2112168564 cites W2019390040 @default.
- W2112168564 cites W2021754558 @default.
- W2112168564 cites W2022673236 @default.
- W2112168564 cites W2024446497 @default.
- W2112168564 cites W2024564404 @default.
- W2112168564 cites W2026742676 @default.
- W2112168564 cites W2028644941 @default.
- W2112168564 cites W2029261932 @default.
- W2112168564 cites W2030074790 @default.
- W2112168564 cites W2030128137 @default.
- W2112168564 cites W2031099314 @default.
- W2112168564 cites W2032404554 @default.
- W2112168564 cites W2032936993 @default.
- W2112168564 cites W2034864326 @default.
- W2112168564 cites W2035016756 @default.
- W2112168564 cites W2035992044 @default.
- W2112168564 cites W2036411319 @default.
- W2112168564 cites W2036635313 @default.
- W2112168564 cites W2036688990 @default.
- W2112168564 cites W2040261042 @default.
- W2112168564 cites W2041731598 @default.
- W2112168564 cites W2044271936 @default.
- W2112168564 cites W2045502788 @default.
- W2112168564 cites W2047089713 @default.
- W2112168564 cites W2050138059 @default.
- W2112168564 cites W2050625990 @default.
- W2112168564 cites W2050805054 @default.
- W2112168564 cites W2052916446 @default.
- W2112168564 cites W2057523983 @default.
- W2112168564 cites W2060108253 @default.
- W2112168564 cites W2063444098 @default.
- W2112168564 cites W2065223208 @default.
- W2112168564 cites W2069055606 @default.
- W2112168564 cites W2069261355 @default.
- W2112168564 cites W2069514570 @default.
- W2112168564 cites W2072232259 @default.
- W2112168564 cites W2073134613 @default.
- W2112168564 cites W2073578515 @default.
- W2112168564 cites W2073688567 @default.
- W2112168564 cites W2074274985 @default.
- W2112168564 cites W2076458350 @default.
- W2112168564 cites W2079210085 @default.
- W2112168564 cites W2079785479 @default.
- W2112168564 cites W2084483597 @default.
- W2112168564 cites W2088677341 @default.
- W2112168564 cites W2089934054 @default.
- W2112168564 cites W2093514501 @default.
- W2112168564 cites W2094001761 @default.
- W2112168564 cites W2097198296 @default.
- W2112168564 cites W2102047788 @default.
- W2112168564 cites W2102689104 @default.
- W2112168564 cites W2103908717 @default.
- W2112168564 cites W2107488886 @default.
- W2112168564 cites W2108302491 @default.
- W2112168564 cites W2109332166 @default.
- W2112168564 cites W2113533986 @default.
- W2112168564 cites W2115769066 @default.
- W2112168564 cites W2116241217 @default.