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• W2112175087 abstract "Iron-dependent oxidative stress, elevated levels of iron and of monoamine oxidase (MAO)-B activity, and depletion of antioxidants in the brain may be major pathogenic factors in Parkinson's disease, Alzheimer's disease and related neurodegenerative diseases. Accordingly, iron chelators, antioxidants and MAO-B inhibitors have shown efficacy in a variety of cellular and animal models of CNS injury. In searching for novel antioxidant iron chelators with potential MAO-B inhibitory activity, a series of new iron chelators has been designed, synthesized and investigated. In this study, the novel chelators were further examined for their activity as antioxidants, MAO-B inhibitors and neuroprotective agents in vitro. Three of the selected chelators (M30, HLA20 and M32) were the most effective in inhibiting iron-dependent lipid peroxidation in rat brain homogenates with IC50 values (12-16 microM), which is comparable with that of desferal, a prototype iron chelator that is not has orally active. Their antioxidant activities were further confirmed using electron paramagnetic resonance spectroscopy. In PC12 cell culture, the three novel chelators at 0.1 microM were able to attenuate cell death induced by serum deprivation and by 6-hydroxydopamine. M30 possessing propargyl, the MAO inhibitory moiety of the anti-Parkinson drug rasagiline, displayed greater neuroprotective potency than that of rasagiline. In addition, in vitro, M30 was a highly potent non-selective MAO-A and MAO-B inhibitor (IC50 < 0.1 microM). However, HLA20 was more selective for MAO-B but had poor MAO inhibition, with an IC50 value of 64.2 microM. The data suggest that M30 and HLA20 might serve as leads in developing drugs with multifunctional activities for the treatment of various neurodegenerative disorders." @default.
• W2112175087 created "2016-06-24" @default.
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• W2112175087 date "2005-08-25" @default.
• W2112175087 modified "2023-10-16" @default.
• W2112175087 title "Novel multifunctional neuroprotective iron chelator-monoamine oxidase inhibitor drugs for neurodegenerative diseases: in vitro studies on antioxidant activity, prevention of lipid peroxide formation and monoamine oxidase inhibition" @default.
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• W2112175087 cites W1497540774 @default.
• W2112175087 cites W1530657831 @default.
• W2112175087 cites W1542569132 @default.
• W2112175087 cites W1603686013 @default.
• W2112175087 cites W1862214936 @default.
• W2112175087 cites W1934800228 @default.
• W2112175087 cites W1967321583 @default.
• W2112175087 cites W1967922486 @default.
• W2112175087 cites W1969291345 @default.
• W2112175087 cites W1979297739 @default.
• W2112175087 cites W1981331199 @default.
• W2112175087 cites W1981819503 @default.
• W2112175087 cites W1986193590 @default.
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• W2112175087 cites W1993964261 @default.
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• W2112175087 cites W1997432328 @default.
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• W2112175087 cites W2003579541 @default.
• W2112175087 cites W2006283117 @default.
• W2112175087 cites W2008836533 @default.
• W2112175087 cites W2013157983 @default.
• W2112175087 cites W2015380696 @default.
• W2112175087 cites W2016232776 @default.
• W2112175087 cites W2017522921 @default.
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• W2112175087 cites W2018974184 @default.
• W2112175087 cites W2019019227 @default.
• W2112175087 cites W2028427953 @default.
• W2112175087 cites W2030644405 @default.
• W2112175087 cites W2031843850 @default.
• W2112175087 cites W2043353183 @default.
• W2112175087 cites W2051176914 @default.
• W2112175087 cites W2051516838 @default.
• W2112175087 cites W2057353165 @default.
• W2112175087 cites W2059963027 @default.
• W2112175087 cites W2063635354 @default.
• W2112175087 cites W2064328844 @default.
• W2112175087 cites W2071483747 @default.
• W2112175087 cites W2072860074 @default.
• W2112175087 cites W2077152493 @default.
• W2112175087 cites W2085842761 @default.
• W2112175087 cites W2091215473 @default.
• W2112175087 cites W2091558615 @default.
• W2112175087 cites W2092880056 @default.
• W2112175087 cites W2093781635 @default.
• W2112175087 cites W2101178389 @default.
• W2112175087 cites W2141533937 @default.
• W2112175087 cites W2144483204 @default.
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• W2112175087 cites W2310067049 @default.
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• W2112175087 doi "https://doi.org/10.1111/j.1471-4159.2005.03340.x" @default.
• W2112175087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16181413" @default.
• W2112175087 hasPublicationYear "2005" @default.
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