Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112230834> ?p ?o ?g. }
- W2112230834 endingPage "1571" @default.
- W2112230834 startingPage "1563" @default.
- W2112230834 abstract "Invasive aspergillosis (IA) is an important cause of morbidity and mortality among immunocompromised patients. Echinocandins are novel antifungal molecules with in vitro and in vivo activity against Aspergillus species.We investigated the efficacy and safety of caspofungin in the treatment of IA. Ninety patients with IA who were refractory to or intolerant of amphotericin B, lipid formulations of amphotericin B, or triazoles were enrolled to receive caspofungin.Efficacy was assessed for 83 patients who had infection consistent with definitions of IA and who received >or=1 dose of study drug. Common underlying conditions included hematologic malignancy (48% of patients), allogeneic blood and marrow transplantation (25% of patients), and solid-organ transplantation (11% of patients). Seventy-one patients (86%) were refractory to and 12 patients (14%) were intolerant of previous therapy. A favorable response to caspofungin therapy was observed in 37 (45%) of 83 patients, including 32 (50%) of 64 with pulmonary aspergillosis and 3 (23%) of 13 with disseminated aspergillosis. Two patients discontinued caspofungin therapy because of drug-related adverse events. Drug-related nephrotoxicity and hepatotoxicity occurred infrequently.Caspofungin demonstrated usefulness in the salvage treatment of IA." @default.
- W2112230834 created "2016-06-24" @default.
- W2112230834 creator A5019544224 @default.
- W2112230834 creator A5021310794 @default.
- W2112230834 creator A5022506632 @default.
- W2112230834 creator A5023798810 @default.
- W2112230834 creator A5033841614 @default.
- W2112230834 creator A5037134717 @default.
- W2112230834 creator A5045441071 @default.
- W2112230834 creator A5046811864 @default.
- W2112230834 creator A5048001001 @default.
- W2112230834 creator A5062839406 @default.
- W2112230834 creator A5063230516 @default.
- W2112230834 creator A5071800632 @default.
- W2112230834 creator A5083752740 @default.
- W2112230834 date "2004-12-01" @default.
- W2112230834 modified "2023-09-29" @default.
- W2112230834 title "Efficacy and Safety of Caspofungin for Treatment of Invasive Aspergillosis in Patients Refractory to or Intolerant of Conventional Antifungal Therapy" @default.
- W2112230834 cites W1936457751 @default.
- W2112230834 cites W1964720826 @default.
- W2112230834 cites W1973512045 @default.
- W2112230834 cites W1975997437 @default.
- W2112230834 cites W1978888709 @default.
- W2112230834 cites W1979180336 @default.
- W2112230834 cites W1986100989 @default.
- W2112230834 cites W1986330094 @default.
- W2112230834 cites W1997351409 @default.
- W2112230834 cites W2003661565 @default.
- W2112230834 cites W2016290575 @default.
- W2112230834 cites W2034522960 @default.
- W2112230834 cites W2035534929 @default.
- W2112230834 cites W2039366893 @default.
- W2112230834 cites W2045138757 @default.
- W2112230834 cites W2050127618 @default.
- W2112230834 cites W2057018930 @default.
- W2112230834 cites W2081985159 @default.
- W2112230834 cites W2082695689 @default.
- W2112230834 cites W2083330927 @default.
- W2112230834 cites W2087548480 @default.
- W2112230834 cites W2098175638 @default.
- W2112230834 cites W2099769947 @default.
- W2112230834 cites W2104240895 @default.
- W2112230834 cites W2104445943 @default.
- W2112230834 cites W2108719290 @default.
- W2112230834 cites W2129948097 @default.
- W2112230834 cites W2133328722 @default.
- W2112230834 cites W2142281465 @default.
- W2112230834 cites W2144030592 @default.
- W2112230834 cites W2149546447 @default.
- W2112230834 cites W2149696039 @default.
- W2112230834 cites W2156228013 @default.
- W2112230834 cites W2164848236 @default.
- W2112230834 cites W2166963066 @default.
- W2112230834 cites W2170261354 @default.
- W2112230834 cites W2170381561 @default.
- W2112230834 cites W2326799365 @default.
- W2112230834 cites W2338427714 @default.
- W2112230834 doi "https://doi.org/10.1086/423381" @default.
- W2112230834 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15578352" @default.
- W2112230834 hasPublicationYear "2004" @default.
- W2112230834 type Work @default.
- W2112230834 sameAs 2112230834 @default.
- W2112230834 citedByCount "609" @default.
- W2112230834 countsByYear W21122308342012 @default.
- W2112230834 countsByYear W21122308342013 @default.
- W2112230834 countsByYear W21122308342014 @default.
- W2112230834 countsByYear W21122308342015 @default.
- W2112230834 countsByYear W21122308342016 @default.
- W2112230834 countsByYear W21122308342017 @default.
- W2112230834 countsByYear W21122308342018 @default.
- W2112230834 countsByYear W21122308342019 @default.
- W2112230834 countsByYear W21122308342020 @default.
- W2112230834 countsByYear W21122308342021 @default.
- W2112230834 countsByYear W21122308342022 @default.
- W2112230834 countsByYear W21122308342023 @default.
- W2112230834 crossrefType "journal-article" @default.
- W2112230834 hasAuthorship W2112230834A5019544224 @default.
- W2112230834 hasAuthorship W2112230834A5021310794 @default.
- W2112230834 hasAuthorship W2112230834A5022506632 @default.
- W2112230834 hasAuthorship W2112230834A5023798810 @default.
- W2112230834 hasAuthorship W2112230834A5033841614 @default.
- W2112230834 hasAuthorship W2112230834A5037134717 @default.
- W2112230834 hasAuthorship W2112230834A5045441071 @default.
- W2112230834 hasAuthorship W2112230834A5046811864 @default.
- W2112230834 hasAuthorship W2112230834A5048001001 @default.
- W2112230834 hasAuthorship W2112230834A5062839406 @default.
- W2112230834 hasAuthorship W2112230834A5063230516 @default.
- W2112230834 hasAuthorship W2112230834A5071800632 @default.
- W2112230834 hasAuthorship W2112230834A5083752740 @default.
- W2112230834 hasBestOaLocation W21122308341 @default.
- W2112230834 hasConcept C126322002 @default.
- W2112230834 hasConcept C141071460 @default.
- W2112230834 hasConcept C142424586 @default.
- W2112230834 hasConcept C16005928 @default.
- W2112230834 hasConcept C197934379 @default.
- W2112230834 hasConcept C203014093 @default.
- W2112230834 hasConcept C2776391196 @default.
- W2112230834 hasConcept C2776694085 @default.