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• W2112232443 endingPage "R33" @default.
• W2112232443 startingPage "R33" @default.
• W2112232443 abstract "The ubiquitin system (Ub-system) can be defined as the ensemble of components including Ub/ubiquitin-like proteins, their conjugation and deconjugation apparatus, binding partners and the proteasomal system. While several studies have concentrated on structure-function relationships and evolution of individual components of the Ub-system, a study of the system as a whole is largely lacking. Using numerous genome-scale datasets, we assemble for the first time a comprehensive reconstruction of the budding yeast Ub-system, revealing static and dynamic properties. We devised two novel representations, the rank plot to understand the functional diversification of different components and the clique-specific point-wise mutual-information network to identify significant interactions in the Ub-system. Using these representations, evidence is provided for the functional diversification of components such as SUMO-dependent Ub-ligases. We also identify novel components of SCF (Skp1-cullin-F-box)-dependent complexes, receptors in the ERAD (endoplasmic reticulum associated degradation) system and a key role for Sus1 in coordinating multiple Ub-related processes in chromatin dynamics. We present evidence for a major impact of the Ub-system on large parts of the proteome via its interaction with the transcription regulatory network. Furthermore, the dynamics of the Ub-network suggests that Ub and SUMO modifications might function cooperatively with transcription control in regulating cell-cycle-stage-specific complexes and in reinforcing periodicities in gene expression. Combined with evolutionary information, the structure of this network helps in understanding the lineage-specific expansion of SCF complexes with a potential role in pathogen response and the origin of the ERAD and ESCRT systems." @default.
• W2112232443 created "2016-06-24" @default.
• W2112232443 creator A5026932356 @default.
• W2112232443 creator A5045663522 @default.
• W2112232443 creator A5048122156 @default.
• W2112232443 creator A5067929237 @default.
• W2112232443 date "2009-01-01" @default.
• W2112232443 modified "2023-09-28" @default.
• W2112232443 title "Reconstructing the ubiquitin network - cross-talk with other systems and identification of novel functions" @default.
• W2112232443 cites W1496897161 @default.
• W2112232443 cites W1537728769 @default.
• W2112232443 cites W1604959358 @default.
• W2112232443 cites W1607874074 @default.
• W2112232443 cites W1911724401 @default.
• W2112232443 cites W196004681 @default.
• W2112232443 cites W1963967499 @default.
• W2112232443 cites W1965324768 @default.
• W2112232443 cites W1966575221 @default.
• W2112232443 cites W1970250905 @default.
• W2112232443 cites W1972111705 @default.
• W2112232443 cites W1973260612 @default.
• W2112232443 cites W1975121208 @default.
• W2112232443 cites W1976251488 @default.
• W2112232443 cites W1980432902 @default.
• W2112232443 cites W1980643159 @default.
• W2112232443 cites W1981551685 @default.
• W2112232443 cites W1982428412 @default.
• W2112232443 cites W1986332383 @default.
• W2112232443 cites W1987601566 @default.
• W2112232443 cites W1988923344 @default.
• W2112232443 cites W1992758160 @default.
• W2112232443 cites W1993009001 @default.
• W2112232443 cites W1995223052 @default.
• W2112232443 cites W2002373110 @default.
• W2112232443 cites W2002374533 @default.
• W2112232443 cites W2002850151 @default.
• W2112232443 cites W2012586415 @default.
• W2112232443 cites W2013158844 @default.
• W2112232443 cites W2013947447 @default.
• W2112232443 cites W2018467767 @default.
• W2112232443 cites W2019654388 @default.
• W2112232443 cites W2020212191 @default.
• W2112232443 cites W2024735335 @default.
• W2112232443 cites W2025497897 @default.
• W2112232443 cites W2027899041 @default.
• W2112232443 cites W2029189334 @default.
• W2112232443 cites W2031300832 @default.
• W2112232443 cites W2031490422 @default.
• W2112232443 cites W2034203606 @default.
• W2112232443 cites W2041006851 @default.
• W2112232443 cites W2042722403 @default.
• W2112232443 cites W2045625811 @default.
• W2112232443 cites W2048586339 @default.
• W2112232443 cites W2048915427 @default.
• W2112232443 cites W2049446489 @default.
• W2112232443 cites W2050721857 @default.
• W2112232443 cites W2051419563 @default.
• W2112232443 cites W2053060343 @default.
• W2112232443 cites W2056775476 @default.
• W2112232443 cites W2058496850 @default.
• W2112232443 cites W2060817283 @default.
• W2112232443 cites W2061409915 @default.
• W2112232443 cites W2063887644 @default.
• W2112232443 cites W2068858732 @default.
• W2112232443 cites W2070476685 @default.
• W2112232443 cites W2070672503 @default.
• W2112232443 cites W2071015335 @default.
• W2112232443 cites W2075220720 @default.
• W2112232443 cites W2077162184 @default.
• W2112232443 cites W2079397912 @default.
• W2112232443 cites W2080553628 @default.
• W2112232443 cites W2081444617 @default.
• W2112232443 cites W2084214748 @default.
• W2112232443 cites W2084619201 @default.
• W2112232443 cites W2085992142 @default.
• W2112232443 cites W2088189164 @default.
• W2112232443 cites W2088724822 @default.
• W2112232443 cites W2090509945 @default.
• W2112232443 cites W2094309012 @default.
• W2112232443 cites W2096646435 @default.
• W2112232443 cites W2097698606 @default.
• W2112232443 cites W2103453943 @default.
• W2112232443 cites W2106119591 @default.
• W2112232443 cites W2106362229 @default.
• W2112232443 cites W2108228282 @default.
• W2112232443 cites W2108490141 @default.
• W2112232443 cites W2109248504 @default.
• W2112232443 cites W2109281577 @default.
• W2112232443 cites W2109344242 @default.
• W2112232443 cites W2112003767 @default.
• W2112232443 cites W2112660386 @default.
• W2112232443 cites W2116117181 @default.
• W2112232443 cites W2118203012 @default.
• W2112232443 cites W2120148489 @default.
• W2112232443 cites W2126644712 @default.
• W2112232443 cites W2127936263 @default.
• W2112232443 cites W2135144130 @default.
• W2112232443 cites W2136128861 @default.

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