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• W2112234668 startingPage "2077" @default.
• W2112234668 abstract "The frequently occurring DNA uptake sequence (DUS), recognized as a 10-bp repeat, is required for efficient genetic transformation in the human pathogens Neisseria meningitidis and Neisseria gonorrhoeae. Genome scanning for DUS occurrences in three different species of Neisseria demonstrated that 76% of the nearly 2,000 neisserial DUS were found to have two semiconserved base pairs extending from the 5' end of DUS to constitute a 12-mer repeat. Plasmids containing sequential variants of the neisserial DUS were tested for their ability to transform N. meningitidis and N. gonorrhoeae, and the 12-mer was found to outperform the 10-mer DUS in transformation efficiency. Assessment of meningococcal uptake of DNA confirmed the enhanced performance of the 12-mer compared to the 10-mer DUS. An inverted repeat DUS was not more efficient in transformation than DNA species containing a single or direct repeat DUS. Genome-wide analysis revealed that half of the nearly 1,500 12-mer DUS are arranged as inverted repeats predicted to be involved in rho-independent transcriptional termination or attenuation. The distribution of the uptake signal sequence required for transformation in the Pasteurellaceae was also biased towards transcriptional terminators, although to a lesser extent. In addition to assessing the intergenic location of DUS, we propose that the 10-mer identity of DUS should be extended and recognized as a 12-mer DUS. The dual role of DUS in transformation and as a structural component on RNA affecting transcription makes this a relevant model system for assessing significant roles of repeat sequences in biology." @default.
• W2112234668 created "2016-06-24" @default.
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• W2112234668 date "2007-03-01" @default.
• W2112234668 modified "2023-10-03" @default.
• W2112234668 title "New Functional Identity for the DNA Uptake Sequence in Transformation and Its Presence in Transcriptional Terminators" @default.
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• W2112234668 doi "https://doi.org/10.1128/jb.01408-06" @default.
• W2112234668 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1855724" @default.
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