FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2112242064> ?p ?o ?g. }

• W2112242064 endingPage "6526" @default.
• W2112242064 startingPage "6515" @default.
• W2112242064 abstract "It has been well established that amino acid availability can control gene expression. Previous studies have shown that amino acid depletion induces transcription of the ATF3 (activation transcription factor 3) gene through an amino acid response element (AARE) located in its promoter. This event requires phosphorylation of activating transcription factor 2 (ATF2), a constitutive AARE-bound factor. To identify the signaling cascade leading to phosphorylation of ATF2 in response to amino acid starvation, we used an individual gene knockdown approach by small interfering RNA transfection. We identified the mitogen-activated protein kinase (MAPK) module MEKK1/MKK7/JNK2 as the pathway responsible for ATF2 phosphorylation on the threonine 69 (Thr69) and Thr71 residues. Then, we progressed backwards up the signal transduction pathway and showed that the GTPase Rac1/Cdc42 and the protein Galpha12 control the MAPK module, ATF2 phosphorylation, and AARE-dependent transcription. Taken together, our data reveal a new signaling pathway activated by amino acid starvation leading to ATF2 phosphorylation and subsequently positively affecting the transcription of amino acid-regulated genes." @default.
• W2112242064 created "2016-06-24" @default.
• W2112242064 creator A5021982989 @default.
• W2112242064 creator A5024093558 @default.
• W2112242064 creator A5025091127 @default.
• W2112242064 creator A5042087350 @default.
• W2112242064 creator A5044642578 @default.
• W2112242064 creator A5048650024 @default.
• W2112242064 creator A5058851443 @default.
• W2112242064 creator A5071744340 @default.
• W2112242064 creator A5088711188 @default.
• W2112242064 date "2009-12-01" @default.
• W2112242064 modified "2023-09-25" @default.
• W2112242064 title "Identification of a Novel Amino Acid Response Pathway Triggering ATF2 Phosphorylation in Mammals" @default.
• W2112242064 cites W1555489233 @default.
• W2112242064 cites W1659944386 @default.
• W2112242064 cites W1749711544 @default.
• W2112242064 cites W1887493033 @default.
• W2112242064 cites W1914399831 @default.
• W2112242064 cites W1963558939 @default.
• W2112242064 cites W1967476432 @default.
• W2112242064 cites W1971357899 @default.
• W2112242064 cites W1975739823 @default.
• W2112242064 cites W1980438612 @default.
• W2112242064 cites W1984052581 @default.
• W2112242064 cites W1984662779 @default.
• W2112242064 cites W1984665850 @default.
• W2112242064 cites W1984903682 @default.
• W2112242064 cites W1986449091 @default.
• W2112242064 cites W1987704983 @default.
• W2112242064 cites W1989602074 @default.
• W2112242064 cites W1990540386 @default.
• W2112242064 cites W1992079665 @default.
• W2112242064 cites W1993401339 @default.
• W2112242064 cites W1998388607 @default.
• W2112242064 cites W1998487776 @default.
• W2112242064 cites W2001893149 @default.
• W2112242064 cites W2003425522 @default.
• W2112242064 cites W2004975140 @default.
• W2112242064 cites W2009725516 @default.
• W2112242064 cites W2010667313 @default.
• W2112242064 cites W2011311205 @default.
• W2112242064 cites W2013966205 @default.
• W2112242064 cites W2018450383 @default.
• W2112242064 cites W2023538497 @default.
• W2112242064 cites W2028936118 @default.
• W2112242064 cites W2031344967 @default.
• W2112242064 cites W2033630180 @default.
• W2112242064 cites W2034047130 @default.
• W2112242064 cites W2034580062 @default.
• W2112242064 cites W2036662476 @default.
• W2112242064 cites W2036771484 @default.
• W2112242064 cites W2039229115 @default.
• W2112242064 cites W2042584344 @default.
• W2112242064 cites W2047604959 @default.
• W2112242064 cites W2048551040 @default.
• W2112242064 cites W2054363543 @default.
• W2112242064 cites W2056415191 @default.
• W2112242064 cites W2067189757 @default.
• W2112242064 cites W2071199281 @default.
• W2112242064 cites W2076485183 @default.
• W2112242064 cites W2078099397 @default.
• W2112242064 cites W2080451230 @default.
• W2112242064 cites W2081826567 @default.
• W2112242064 cites W2082565048 @default.
• W2112242064 cites W2085753855 @default.
• W2112242064 cites W2086524624 @default.
• W2112242064 cites W2086589468 @default.
• W2112242064 cites W2086687315 @default.
• W2112242064 cites W2089856977 @default.
• W2112242064 cites W2094543218 @default.
• W2112242064 cites W2096931514 @default.
• W2112242064 cites W2096934884 @default.
• W2112242064 cites W2101445704 @default.
• W2112242064 cites W2107014487 @default.
• W2112242064 cites W2109747477 @default.
• W2112242064 cites W2113067498 @default.
• W2112242064 cites W2115311570 @default.
• W2112242064 cites W2118337893 @default.
• W2112242064 cites W2119455089 @default.
• W2112242064 cites W2126519916 @default.
• W2112242064 cites W2126746388 @default.
• W2112242064 cites W2128600167 @default.
• W2112242064 cites W2128685285 @default.
• W2112242064 cites W2131632095 @default.
• W2112242064 cites W2132188426 @default.
• W2112242064 cites W2135086805 @default.
• W2112242064 cites W2135768629 @default.
• W2112242064 cites W2139568257 @default.
• W2112242064 cites W2144346571 @default.
• W2112242064 cites W2146922843 @default.
• W2112242064 cites W2148046166 @default.
• W2112242064 cites W2150178760 @default.
• W2112242064 cites W2158973316 @default.
• W2112242064 cites W2167411243 @default.
• W2112242064 cites W2169187666 @default.
• W2112242064 cites W2169903226 @default.
• W2112242064 cites W2170989878 @default.

• next